A Novel Composite Membrane for pH Responsive Permeation | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 3، دوره 11، شماره 2، تیر 2008، صفحه 70-79 اصل مقاله (1.7 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2008.5199 | ||
| نویسندگان | ||
| Elham Khodaverdi* 1؛ Omid Rajabi2؛ Mohammad Abdekhodai3؛ Xiao Yu Wu4 | ||
| 1Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Pharmaceutics, School of Chemical Engineering, Sharif University, Tehran, Iran | ||
| 4Department of Pharmaceutics, School of Pharmacy, University of Toronto, Toronto, Canada | ||
| چکیده | ||
| Objective(s) In this study, a kind of pH sensitive composite membrane was prepared and drug permeation through it was investigated in terms of pH. Rationale of this study originated from the fact that a pH change which may be a result of a disease state in the body can trigger drug release. Materials and Methods Here, a kind of pH sensitive composite membrane containing different nanoparticle [1:1 n-isopropyl acrylamide (Nipam): metacrylic acid (Maa)] contents in ethylcellulose was prepared by a casting method. Swelling ratios of these nanoparticles and composite membranes with different particle loadings were determined. Permeation of two different drug models with different hydrophilicity and molecular weights, vitamin B12 (vit B12) and paracetamol, through these membranes was studied in terms of pH. Results It was seen that swelling ratios of nanoparticles and the composite membranes went up as the particle content increased at each pH. Vit B12 and paracetamol permeation through the membranes in pH value below the pKa was much higher than that at pHs above it, but this difference was much more pronounced for vit B12 compared to paracetamol. Conclusion Permeation through these membranes showed a sharp sensitivity to pH changes. Nanoparticles in the composite membranes could act as nanovalves due to their sharp swelling/shrinkage around the pKa of Maa. These membranes could be considered as an ideal stimuli-sensitive barrier for modulating drug release with a small change in pH. | ||
| کلیدواژهها | ||
| Composite membranes؛ Permeation؛ Nanoparticles؛ pH-sensitivity | ||
| مراجع | ||
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