Antinociceptive Effect of Promethazine in Mice | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 3، دوره 12، شماره 3، مهر 2009، صفحه 140-145 اصل مقاله (116.21 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2009.5166 | ||
| نویسندگان | ||
| Amir Farshchi* 1، 2؛ Golbarg Ghiasi1؛ Peyman Malek Khatabi1؛ Hosein Farzaee1؛ Amin Niayesh3 | ||
| 1School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 2Young Researchers Club, Islamic Azad University, Kermanshah branch, Iran | ||
| 3School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran | ||
| چکیده | ||
| Objective(s) The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. Materials and Methods Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. Results Promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhibition of the second phase response in the formalin pain model (P<0.05) and the drug couldn’t show an antinociceptive effect in the first phase. Morphine (10 mg/kg) inhibited both first and second phase response (P<0.01). Drug also showed a dose-dependent inhibition of acetic acid-induced abdominal writhes. The tail flick and hot plate latency weren’t different from control (P>0.05) and administration of naloxone (0.1 mg/kg) couldn't block the antinociceptive effect of promethazine. Conclusion The data obtained suggest that antinociceptive effects of the promethazine may be mediated via peripheral and not central mechanisms. | ||
| کلیدواژهها | ||
| Antinociceptive؛ Formalin test؛ Hot plate؛ Promethazine؛ Tail flick؛ Writhing test | ||
| مراجع | ||
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