Teratogenic effect of Lippia citriodora leaves aqueous extract in mice | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 4، دوره 6، شماره 2، خرداد و تیر 2016، صفحه 175-180 اصل مقاله (403.94 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2016.5128 | ||
| نویسندگان | ||
| Zahra Oskouei Shirvan1؛ Leila Etemad2؛ Reza Zafari1؛ Seyed Adel Moallem1؛ Naser Vahdati-Mashhadian3؛ Hossein Hosseinzadeh* 4 | ||
| 1Departments of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Medical Toxicology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective: Safety of Lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. This study aimed to identify the effect of L. citriodora aqueous extract on pregnancy outcome in mice. Materials and Methods: Timed-pregnant mice received doses of 0.5 g/kg/day L. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. Maternal body weights were measured throughout the pregnancy. The litters were examined for external malformations and skeletal abnormalities. Fetuses were stained with Alizarin red S and Alcian blue. Results: There were no significant differences in mean maternal weight gain during pregnancy between groups. Also, no significant differences were observed in mean number of implantation, live and resorbed fetuses between control and treated groups. The prevalence of all types of deformity was low and similar to control group (%1.11). Conclusion: The results of this study show that moderate consumption of L. citriodora as an infusion or tea appears to be safe to be used during pregnancy and does not have toxic effects on development of mouse embryo. | ||
| کلیدواژهها | ||
| Lippia citriodora؛ Teratogen؛ Toxicity؛ Herbal Medicine | ||
| مراجع | ||
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