Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 2، دوره 12، شماره 1، فروردین 2009، صفحه 9-17 اصل مقاله (336.9 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2009.5126 | ||
| نویسندگان | ||
| Mohammad Allahtavakoli* 1؛ Aliasghar Pourshanazari1؛ Behnam Heshmatian2 | ||
| 1Department of Physiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| 2Department of Physiology, School of Medicine, West Azarbaeejan University of Medical Sciences, Oroomiah, Iran | ||
| چکیده | ||
| Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and Methods Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, a-TCT (1 or 10 mg/kg), RGZ and sham-operation. Results Compared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05) and sensory impairments (P<0.01) but low and high doses of a-TCT did not show any significant neuroprotective effect. Conclusion Our data showed that a-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of a-TCT after stroke. | ||
| کلیدواژهها | ||
| Alpha-tocotrienol؛ Cerebral ischemia؛ Embolic model؛ Neuroprotection؛ Vitamin E | ||
| مراجع | ||
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