Effects of Boswellia Papyrifera Gum Extract on Learning and Memory in Mice and Rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 2، دوره 13، شماره 2، تیر 2010، صفحه 9-15 اصل مقاله (54.04 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2010.5075 | ||
| نویسندگان | ||
| Amir Farshchi* 1، 2؛ Golbarg Ghiasi1، 2؛ Samireh Farshchi3؛ Peyman Malek Khatabi4 | ||
| 1School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 2Department of Pharmocoeconomy and Pharmaceutical Management, Shcool of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of otolaryngology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran | ||
| چکیده | ||
| Objective(s) Learning is defined as the acquisition of information and skills, while subsequent retention of that information is called memory. The objective of the present study was to investigate the effect of aqueous extract of Boswellia papyrifera on learning and memory paradigms in mice and rats. Materials and Methods This study was held at the Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran from September 2006 to March 2008. Male Wistar rats and male NMRI mice were randomly divided into control, B. papyrifera treated (50, 100, 150 mg/kg, p.o.), and piracetam (150 mg/kg) groups. Radial arm maze (RAM) and Morris water maze (MWM) were the screening tests used to assess the activity of B. papyrifera extract. Results The mice treated with B. papyrifera (50, 100 and 150 mg/kg) or piracetam (150 mg/kg) showed a decrease in number of days required to learned (P< 0.05) and time taken to find food by the learned mice in radial arm maze (P< 0.01). In Morris water maze, rats treated with the above mentioned doses showed dose dependent improvement in spatial learning. Escape latency during swimming in water maze in piracetam and B. papyrifera treated animals was significantly lower (P< 0.01) than control. Swimming distance was also significantly lower (P< 0.05) in the treated groups. Conclusion The results show facilitation of spatial learning and memory processes and thereby validate B. papyrifera traditional use of intelligence improving. The presence of alkaloids, flavonoids and saponins might be responsible for this activity of B. papyrifera. | ||
| کلیدواژهها | ||
| Boswellia papyrifera؛ Cognition؛ Morris Water Maze؛ Radial arm maze؛ Spatial learning and Memory | ||
| مراجع | ||
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