Urine Monocyte Chemoattractant Protein-1(UMCP-1) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 12، دوره 15، شماره 6، بهمن 2012، صفحه 1191-1195 اصل مقاله (233.44 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2012.4944 | ||
| نویسندگان | ||
| Zahra Mirfeizi1؛ Mahmoud Mahmoudi2؛ Masih Naghibi3؛ Mohammmadreza Hatef1؛ Farzaneh Sharifipour* 3؛ Mohammadhassan Jokar1؛ Abbasali Zeraati3؛ Zhaleh Shariati Sarabi1؛ AmirAbbas Azarian4 | ||
| 1Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Immunology Research Centre (IRC), Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Vice Chancellor for Research Office, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s) Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus. Materials and Methods Forty-one recently diagnosed systemic lupus erythematosus patients (8 male and 33 female) without renal involvement (group 1) and twenty six patients (8 male and 18 female) with LN (group 2), proven by biopsy, were recruited to this study. UMCP-1 sensitivity and specificity for identifying biopsy-proven nephritis were calculated, and a receiver operating characteristic (ROC) curve was constructed to quantify how definitely UMCP-1 distinguishes between patients with and without LN. Results The mean value of UMCP-1 levels were 733.07 pg/ml ± 1282.54 and 144.16 pg/ml ± 137.90 in patients with and without LN respectively. The UMCP-1 level was significantly higher in group 2 than group 1. There was no significant correlation between UMCP-1 and 24-hour urine protein (r = 0.031, P= 0.874). The area under the ROC curve was 0.727 with a CI 95% of 0.597 to 0.857 (P=0.002). Using a cut-off value of 82 pg/ml,UMCP-1 had a sensitivity of 88.5% and a specificity of 46.3% for identifying LN. Conclusion UMCP-1 can serve as a biomarker of LN although further longitudinal studies of these biomarkers are required in LN. | ||
| کلیدواژهها | ||
| Lupus nephritis؛ Monocyte chemoattractant protein 1؛ systemic lupus erythematosus؛ Urine | ||
| مراجع | ||
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