سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Khazaei, Majid, Nematbakhsh, Mehdi. (1391). Experimentally-Induced Metabolic Acidosis Does not Alter Aortic Fatty Streak Formation in High-Cholesterol Fed Rabbits. , 15(6), 1168-1172. doi: 10.22038/ijbms.2012.4936
Majid Khazaei; Mehdi Nematbakhsh. "Experimentally-Induced Metabolic Acidosis Does not Alter Aortic Fatty Streak Formation in High-Cholesterol Fed Rabbits". , 15, 6, 1391, 1168-1172. doi: 10.22038/ijbms.2012.4936
Khazaei, Majid, Nematbakhsh, Mehdi. (1391). 'Experimentally-Induced Metabolic Acidosis Does not Alter Aortic Fatty Streak Formation in High-Cholesterol Fed Rabbits', , 15(6), pp. 1168-1172. doi: 10.22038/ijbms.2012.4936
Khazaei, Majid, Nematbakhsh, Mehdi. Experimentally-Induced Metabolic Acidosis Does not Alter Aortic Fatty Streak Formation in High-Cholesterol Fed Rabbits. , 1391; 15(6): 1168-1172. doi: 10.22038/ijbms.2012.4936

Experimentally-Induced Metabolic Acidosis Does not Alter Aortic Fatty Streak Formation in High-Cholesterol Fed Rabbits

Iranian Journal of Basic Medical Sciences
مقاله 8، دوره 15، شماره 6، بهمن 2012، صفحه 1168-1172    اصل مقاله (368.86 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2012.4936
نویسندگان
Majid Khazaei* 1؛ Mehdi Nematbakhsh2
1Department of Physiology; Isfahan University of Medical Sciences, Isfahan, Iran
2Water and Electrolytes Research Center, Isfahan University of Medical sciences, Isfahan, Iran
چکیده
Objective(s)
Cardiovascular disease causes a major clinical problem in patients with end stage renal disease. Since metabolic acidosis is very common in patients with end stage renal disease, we aimed to investigate the effect of experimentally-induced metabolic acidosis on serum lipid profile and aortic fatty streak (FS) formation in normal and high-cholesterol fed rabbits.
Materials and Methods
Twenty-four male rabbits were divided into four groups (n=6 each): (1) normal diet (ND): (2) hypercholesterolemic diet (HCD) (1%): (3) ND plus acidemic diet: (4) HCD plus acidemic diet. Metabolic acidosis was induced by adding 0.75% NH4Cl in drinking water. After 4 weeks, blood samples were taken and thoracic aortae were dissected for histological examinations.
Results
Results showed that in the animals who received NH4Cl, metabolic acidosis was successfully induced. Serum total cholesterol and low density lipoprotein (LDL) concentrations in HCD groups were significantly higher than ND groups (P<0.05) and acidosis did not significantly change serum lipid levels neither in ND nor in HCD animals (P>0.05). Histological examination of aortae showed higher mean average grades of pathological evaluation in HCD than ND groups (2.1±0.16 vs. 0±0; P<0.05). Acidosis did not further increase FS formation in HCD groups (P >0.05).
Conclusion
In this model of experimentally-induced metabolic acidosis, acidosis could not increase FS formation in HCD animals and it seems that it does not interfere in progression of atherosclerosis process.
کلیدواژه‌ها
Acidosis؛ Fatty streak؛ Hypercholesterolemia
مراجع
1. Glass CK, Witztum JL. Atherosclerosis. the road ahead. Cell 2001; 104:503-516.
2. Lusis AJ. Atherosclerosis. Nature 2000; 407:233-241.
3. Amann K, Tyralla K, Gross ML, Eifert T, Adamczak M, Ritz E. Special characteristics of atherosclerosis in chronic renal failure. Clin Nephrol 2003; 60:S13-S21.
4. Valderrabano F, Jones EH, Mallick NP. Report on management of renal failure in Europe, XXIV, 1993. Nephrol Dial Transplant 1995; 10:1-25.
5. Collins AJ. Cardiovascular mortality in end-stage renal disease. Am J Med Sci 2003; 325:163-167.
6. O'Hare AM, Glidden DV, Fox CS, Hsu CY. High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999-2000. Circulation 2004; 109:320-323.
7. Schwarz U, Buzello M, Ritz E, Stein G, Raabe G, Wiest G, et al. Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure. Nephrol Dial Transplant 2000; 15:218-223.
8. Kalantar-Zadeh K, Stenvinkel P, Pillon L, Kopple JD. Inflammation and nutrition in renal insufficiency. Adv Ren Replace Ther 2003; 10:155-169.
9. Amann K, Tyralla K, Gross ML, Eifert T, Adamczak M, Ritz E. Special characteristics of atherosclerosis in chronic renal failure. Clin Nephrol 2003; 60:S13-S21.
10. Keaney JF Jr. Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction. Mol Aspects Med 2000; 21:99-166.
11. Zhao SP. Effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic rabbits. Int J Cardiol 2008; 29:124:172-178.
12. Pakala R. Peroxisome proliferator-activated receptor gamma ligand pioglitazone alters neointimal composition in a balloon-denuded and radiated hypercholesterolemic rabbit. J Cardiovasc Pharmacol 2006; 48:299-305.
13. Tovar AM, Pecly IM, Rangel EP, Melo-Filho NM, Mourao PA, Leite M Jr. Experimentally induced metabolic acidosis in rabbits modulates the interaction of aortic glycosaminoglycan with plasma low-density lipoprotein-an interesting observation about the association of acidosis and atherosclerosis. Atherosclerosis 2007; 192:33-39.
14. Oomen CM. Arginine intake and risk of coronary heart disease mortality in elderly men. Arterioscler Thromb Vasc Biol 2000; 20:2134-2139.
15. London GM. Alterations of arterial function in end-stage renal disease. Nephron 2000; 84:111-118.
16. Campean V, Neureiter D, Varga I, Runk F, Reiman A, Garlichs C, et al. Atherosclerosis and vascular calcification in chronic renal failure. Kidney Blood Press Res 2005; 28:280-289.
17. Leake DS. Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions? Atherosclerosis 1997; 129:149-157.

آمار
تعداد مشاهده مقاله: 1,473
تعداد دریافت فایل اصل مقاله: 757