Najafpour Boushehri, Saeid, Mohammad Yusof, Rokiah, Nasir Mohammad Taib, Mohammad, Mirzaei, Kamran, Yazdekhasti, Narges, Akbarzadeh, Samad. (1391). Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors. , 15(4), 958-964. doi: 10.22038/ijbms.2012.4892
Saeid Najafpour Boushehri; Rokiah Mohammad Yusof; Mohammad Nasir Mohammad Taib; Kamran Mirzaei; Narges Yazdekhasti; Samad Akbarzadeh. "Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors". , 15, 4, 1391, 958-964. doi: 10.22038/ijbms.2012.4892
Najafpour Boushehri, Saeid, Mohammad Yusof, Rokiah, Nasir Mohammad Taib, Mohammad, Mirzaei, Kamran, Yazdekhasti, Narges, Akbarzadeh, Samad. (1391). 'Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors', , 15(4), pp. 958-964. doi: 10.22038/ijbms.2012.4892
Najafpour Boushehri, Saeid, Mohammad Yusof, Rokiah, Nasir Mohammad Taib, Mohammad, Mirzaei, Kamran, Yazdekhasti, Narges, Akbarzadeh, Samad. Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors. , 1391; 15(4): 958-964. doi: 10.22038/ijbms.2012.4892

Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors

Iranian Journal of Basic Medical Sciences
مقاله 9، دوره 15، شماره 4، 2012، صفحه 958-964    اصل مقاله (126.27 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2012.4892
نویسندگان
Saeid Najafpour Boushehri* 1؛ Rokiah Mohammad Yusof2؛ Mohammad Nasir Mohammad Taib2؛ Kamran Mirzaei1؛ Narges Yazdekhasti3؛ Samad Akbarzadeh1
1Faculty of Health, Bushehr University of Medical Sciences. Bushehr, Iran
2Department of Nutrition and Dietetics. Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia
3Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences. Isfahan, Iran
چکیده
Objective(s)
Oxidized low-density lipoproteins (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors.
Materials and Methods
The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after 12 weeks of supplementation with vitamin E (400 IU), C (500 mg), ß-carotene (15 mg), and the combined supplements (E, C, and ß-carotene) respectively defined as group E, C, B and control group was considered as group P.
Results
The mean values for ox-LDL at the baseline were 86.93 ± 26.30 U/l in group C, 94.52 ± 38.40 U/l in group E, 79.73±2.07 U/l in group B, 85.97±23.07 U/l in combined group, and 84.90± 14.66 U/l in group P. After 12 weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P< 005).
Conclusion
This study illustrated that diet supplemented with vitamin C (500 mg), vitamin E (400 IU), ß-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-LDL levels.
کلیدواژه‌ها
Cardiovascular diseases؛ Oxidized Low-Density Lipoprotein؛ Vitamin E؛ Vitamin C؛ ß-carotene
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