Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 9، دوره 15، شماره 4، مهر 2012، صفحه 958-964 اصل مقاله (126.27 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2012.4892 | ||
| نویسندگان | ||
| Saeid Najafpour Boushehri* 1؛ Rokiah Mohammad Yusof2؛ Mohammad Nasir Mohammad Taib2؛ Kamran Mirzaei1؛ Narges Yazdekhasti3؛ Samad Akbarzadeh1 | ||
| 1Faculty of Health, Bushehr University of Medical Sciences. Bushehr, Iran | ||
| 2Department of Nutrition and Dietetics. Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia | ||
| 3Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences. Isfahan, Iran | ||
| چکیده | ||
| Objective(s) Oxidized low-density lipoproteins (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors. Materials and Methods The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after 12 weeks of supplementation with vitamin E (400 IU), C (500 mg), ß-carotene (15 mg), and the combined supplements (E, C, and ß-carotene) respectively defined as group E, C, B and control group was considered as group P. Results The mean values for ox-LDL at the baseline were 86.93 ± 26.30 U/l in group C, 94.52 ± 38.40 U/l in group E, 79.73±2.07 U/l in group B, 85.97±23.07 U/l in combined group, and 84.90± 14.66 U/l in group P. After 12 weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P< 005). Conclusion This study illustrated that diet supplemented with vitamin C (500 mg), vitamin E (400 IU), ß-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-LDL levels. | ||
| کلیدواژهها | ||
| Cardiovascular diseases؛ Oxidized Low-Density Lipoprotein؛ Vitamin E؛ Vitamin C؛ ß-carotene | ||
| مراجع | ||
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