Effect of Cannabinoid Receptor Activation on Spreading Depression | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 5، دوره 15، شماره 4، مهر 2012، صفحه 926-936 اصل مقاله (286.22 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2012.4880 | ||
| نویسندگان | ||
| Hadi Kazemi1، 2؛ Mehdi Rahgozar3؛ Erwin-Josef Speckmann4، 5؛ Ali Gorji* 3 | ||
| 1Shefa Neuroscience Research Centre, Tehran, Iran | ||
| 2Department of Pediatrics, Shahed University, Tehran, Iran | ||
| 3Institut für Physiologie I, Westfalische Wilhelms-Universitat Munster, Münster, Germany | ||
| 4Institut für Physiologie I, Westfalische Wilhelms-Universitat Munster, Münster, German | ||
| 5Institut für Experimentelle Epilepsieforschung, Westfalische Wilhelms-Universitat Munster, Münster, Germany | ||
| چکیده | ||
| Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods The effects of Delta9-tetrahydrocannabinol (THC), as well as, cannabinoid CB1 and CB2 receptor agonists on CSD in rat neocortical slices were investigated. Furthermore, the effect of cannabinoid CB1 agonist was tested on field excitatory postsynaptic potentials (fEPSP) and long-term potentiation (LTP). Results HC (1-20 microM) dose dependently suppressed CSD amplitude, duration, and propagation velocity. Cannabinoid CB1 agonist, WIN 55,212-2 mesylate (1-10 microM), also significantly suppressed all characteristic features of CSD. However, cannabinoid CB2 agonist, JWH-133 (1-20 microM), did not affect CSD. FEPSP and induction of LTP were suppressed by application of WIN55212-2. Conclusion Suppression of CSD by activation of CB1 receptors points to the potential therapeutic effects of cannabinoids in migraine with aura. More research is needed before we know whether cannabinoids may be helpful in treating migraine pain. | ||
| کلیدواژهها | ||
| Endocannabinoid؛ Headache؛ Marijuana؛ Migraine؛ Pharmacotherapy؛ Synaptic transmission | ||
| مراجع | ||
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