سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Dezfulian, Anahita, Aslani, Mohammad Mehdi, Oskoui, Mahvash, Farrokh, Parisa, Azimirad, Masumeh, Dabiri, Hossein, Salehian, 1Mohammad Taghi, Zali, 1Mohammad Reza. (1390). Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring VanA Gene Cluster Isolated from Diabetic Foot Ulcer. , 15(2), 783-786. doi: 10.22038/ijbms.2012.4853
Anahita Dezfulian; Mohammad Mehdi Aslani; Mahvash Oskoui; Parisa Farrokh; Masumeh Azimirad; Hossein Dabiri; 1Mohammad Taghi Salehian; 1Mohammad Reza Zali. "Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring VanA Gene Cluster Isolated from Diabetic Foot Ulcer". , 15, 2, 1390, 783-786. doi: 10.22038/ijbms.2012.4853
Dezfulian, Anahita, Aslani, Mohammad Mehdi, Oskoui, Mahvash, Farrokh, Parisa, Azimirad, Masumeh, Dabiri, Hossein, Salehian, 1Mohammad Taghi, Zali, 1Mohammad Reza. (1390). 'Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring VanA Gene Cluster Isolated from Diabetic Foot Ulcer', , 15(2), pp. 783-786. doi: 10.22038/ijbms.2012.4853
Dezfulian, Anahita, Aslani, Mohammad Mehdi, Oskoui, Mahvash, Farrokh, Parisa, Azimirad, Masumeh, Dabiri, Hossein, Salehian, 1Mohammad Taghi, Zali, 1Mohammad Reza. Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring VanA Gene Cluster Isolated from Diabetic Foot Ulcer. , 1390; 15(2): 783-786. doi: 10.22038/ijbms.2012.4853

Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring VanA Gene Cluster Isolated from Diabetic Foot Ulcer

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 15، شماره 2، خرداد 2012، صفحه 783-786    اصل مقاله (160.12 K)
شناسه دیجیتال (DOI): 10.22038/ijbms.2012.4853
نویسندگان
Anahita Dezfulian1؛ Mohammad Mehdi Aslani* 2؛ Mahvash Oskoui2؛ Parisa Farrokh2؛ Masumeh Azimirad1؛ Hossein Dabiri1؛ 1Mohammad Taghi Salehian1؛ 1Mohammad Reza Zali1
1Research Centre of Gastroenterology and Liver Diseases (RCGLD) in Shahid Beheshti University, Tehran, Iran
2Department of Microbiology, Institute Pasteur of Iran, Tehran, Iran
چکیده
Objective(s)
Staphylococcus aureus is a common cause of human infection, and emergence of vancomycin-resistance S. aureus  is a great concern for treatment of methicillin-resistant S. aureus,(MRSA) in recent years (MRSA). Here, we report the isolation of high-level VRSA.
Materials and Methods
S. aureus was isolated from foot ulcer of a diabetic woman in Tehran, Iran. Antibiotic susceptibility was determined according to CLSI guidelines. VanA gene cluster PCR was carried out and PCR amplicon of vanA was sequenced.
Results
S. aureus had high-level vancomycin-resistant (MIC 512 ≥ µg/ml). Patient's history revealed that VRSA isolate was acquired through community transmission. Only vanA, vanR and vanS genes were amplified in our isolate. Sequencing revealed that the vanA sequence had high similarity to the vanA sequence of Tn1546.
Conclusion
Although VRSA infection continues to be rare, isolation of community–acquired VRSA is a significant issue and it needs the efforts of public health authorities.
 
کلیدواژه‌ها
Community-Acquired Infections؛ MRSA؛ Vancomycin Resistance
مراجع

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