Kermani, Tayyebeh, Mousavi, Seyyed Hadi, Shemshian, Maryam, Norouzy, Abdolreza, Mazidi, Mohsen, Moezzi, Atefeh, Moghiman, Toktam, Ghayour-Mobarhan, Majid, Ferns, Gordon. A.. (1394). Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial. , 5(5), 427-433. doi: 10.22038/ajp.2015.4672
Tayyebeh Kermani; Seyyed Hadi Mousavi; Maryam Shemshian; Abdolreza Norouzy; Mohsen Mazidi; Atefeh Moezzi; Toktam Moghiman; Majid Ghayour-Mobarhan; Gordon. A. Ferns. "Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial". , 5, 5, 1394, 427-433. doi: 10.22038/ajp.2015.4672
Kermani, Tayyebeh, Mousavi, Seyyed Hadi, Shemshian, Maryam, Norouzy, Abdolreza, Mazidi, Mohsen, Moezzi, Atefeh, Moghiman, Toktam, Ghayour-Mobarhan, Majid, Ferns, Gordon. A.. (1394). 'Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial', , 5(5), pp. 427-433. doi: 10.22038/ajp.2015.4672
Kermani, Tayyebeh, Mousavi, Seyyed Hadi, Shemshian, Maryam, Norouzy, Abdolreza, Mazidi, Mohsen, Moezzi, Atefeh, Moghiman, Toktam, Ghayour-Mobarhan, Majid, Ferns, Gordon. A.. Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial. , 1394; 5(5): 427-433. doi: 10.22038/ajp.2015.4672

Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial

Avicenna Journal of Phytomedicine
مقاله 7، دوره 5، شماره 5، آذر و دی 2015، صفحه 427-433    اصل مقاله (562.72 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2015.4672
نویسندگان
Tayyebeh Kermani1؛ Seyyed Hadi Mousavi2؛ Maryam Shemshian3؛ Abdolreza Norouzy3؛ Mohsen Mazidi4؛ Atefeh Moezzi3؛ Toktam Moghiman3؛ Majid Ghayour-Mobarhan* 5؛ Gordon. A. Ferns6
1Department of Anatomy and Cell biology, Birjand University of Medical Sciences, Birjand, Iran.
2Pharmacological Research Center of Medicinal Plant, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
3Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
4Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Beijing, China.
5Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
6Division of Medical Education, Brighton & Sussex Medical School, Rm 342, Mayfield House, University of Brighton, BN1 9PH, United Kingdom
چکیده
Objectives: We have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (PAB) in individuals with metabolic syndrome.
Materials and Methods: A randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron and (2) the placebo control group received placebo for 12 weeks. The serum PAB assay was applied to all subjects before (week 0) and after (weeks 6 and 12) the intervention.
Results: There was a significant (p=0.035) reduction in serum PAB between week 0 to week 6 and also from week 0 to week 12. 
Conclusion: Saffron supplements can modulate serum PAB in subjects with metabolic syndrome, implying an improvement in some aspects of oxidative stress or antioxidant protection.
کلیدواژه‌ها
metabolic syndrome؛ Prooxidant-antioxidant balance؛ Saffron
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