Hosseini, Azar, Mousavi, Seyed Hamed, Ghanbari, Anis, Homaei-Shandiz, Fatemeh, Raziee, Hamid-Reza, Pezeshki-Rad, Masoud, Mousavi, Seyed Hadi. (1394). Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial. , 5(5), 434-440. doi: 10.22038/ajp.2015.4667
Azar Hosseini; Seyed Hamed Mousavi; Anis Ghanbari; Fatemeh Homaei-Shandiz; Hamid-Reza Raziee; Masoud Pezeshki-Rad; Seyed Hadi Mousavi. "Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial". , 5, 5, 1394, 434-440. doi: 10.22038/ajp.2015.4667
Hosseini, Azar, Mousavi, Seyed Hamed, Ghanbari, Anis, Homaei-Shandiz, Fatemeh, Raziee, Hamid-Reza, Pezeshki-Rad, Masoud, Mousavi, Seyed Hadi. (1394). 'Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial', , 5(5), pp. 434-440. doi: 10.22038/ajp.2015.4667
Hosseini, Azar, Mousavi, Seyed Hamed, Ghanbari, Anis, Homaei-Shandiz, Fatemeh, Raziee, Hamid-Reza, Pezeshki-Rad, Masoud, Mousavi, Seyed Hadi. Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial. , 1394; 5(5): 434-440. doi: 10.22038/ajp.2015.4667

Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial

Avicenna Journal of Phytomedicine
مقاله 8، دوره 5، شماره 5، آذر و دی 2015، صفحه 434-440    اصل مقاله (481.24 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2015.4667
نویسندگان
Azar Hosseini1؛ Seyed Hamed Mousavi2؛ Anis Ghanbari2؛ Fatemeh Homaei-Shandiz3؛ Hamid-Reza Raziee3؛ Masoud Pezeshki-Rad4؛ Seyed Hadi Mousavi* 5
1Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Department of Oncology, Omid Hospitsal, Mashhad, Iran.
4Department of Oncology, Emam Reza Hospitsal, Mashhad, Iran.
5Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Objective: Cancer represents the second cause of mortality in the world. Saffron as a medicinal plant is known for its anti-cancer and anti-depressant properties. In this randomized double blind clinical trial, the effects of saffron on response to treatment in patients suffering from liver metastasis were evaluated.
Materials and Methods: Thirteen patients suffering from liver metastases who referred to Ghaem and Imam Reza hospital, Mashhad, Iran were included in this study and then divided into two different groups. Both groups received chemotherapy regimen. Patients in group one were treated with saffron capsule (50 mg, twice daily) during chemotherapy periods whereas patients in group two received placebo. A sum of the longest diameter were calculated and compared for all lesions in IV contrast CT scan before and after the treatment.
Results: from 13 patients included in this study, six patients quit and seven continued until the end. In saffron-treated group, two patients showed partial and complete response (50%) whereas in placebo group, no response was seen. Also, two deaths in placebo and one in saffron group occurred.
Conclusion: This research suggests that saffron might be useful in patients suffering from liver metastasis. However, further investigations with larger sample size are required.
کلیدواژه‌ها
Saffron؛ Cancer؛ Liver Metastases
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