Comparison of Anti-Saccharomyces Cerevisiae Antibodies (ASCA) in Behcet’s Disease Patients with Three Groups of Oral Aphthosis, other Rheumatologic Diseases and Healthy Volunteers | ||
| Journal of Patient Safety & Quality Improvement | ||
| مقاله 5، دوره 3، شماره 3، مهر 2015، صفحه 257-261 اصل مقاله (281.88 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/psj.2015.4565 | ||
| نویسندگان | ||
| Saeed Kerdari؛ Mohammad Hassan Jokar* ؛ Seyedeh Zahra Mirfeizi؛ Vahid Yahyavi | ||
| Department of Internal Medicine, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| چکیده | ||
| Introduction: Behcet’s Disease (BD) is a general and progressive vasculitis and involves various organs. Its main etiology is not yet understood; however, immunologic and infectious causes and genetic predisposition have been proposed. Saccharomyces Cerevisiae is a type of yeast which is used in the bread and wine industries. Antibodies against this yeast have a well-proven role in inflammatory bowel diseases. The aim of the present study was to assess the frequency of Anti-Saccharomyces Cerevisiae Antibody (ASCA) and its relation to clinical symptoms and disease activity index in patients afflicted by BD. Materials and Methods: Serum ASCA levels, determined by ELISA, were Studied in Behcet’s disease along with oral aphthosis, other rheumatologic diseases and healthy volunteers (n=30 in each group). In the BD group the disease activity index and different clinical symptoms were recorded during the study course. Results:Serum level of ASCA in the four studied groups of BD, oral aphthosis, other rheumatologic disease and healthy volunteers was 9.18±9.69, 10.90±10.40, 11.29±17.96 and 8.86±5.31IU/ml, respectively; indicating no meaningful difference (p=0.811). The ASCA titer was not related to Behcet’s disease severity (p=0.399). Serum level of ASCA in BD patients with oral aphthosis or with gastrointestinal symptoms was significantly higher than the other Behcet’s Disease patients (p=0.012, p=0.014). Conclusion: ASCS is not a valuable test for distinguishing BD from recurrent oral aphthosis or other connective tissue disorders. It also cannot be used for determining disease severity. However, it has a higher level in BD patients with oral aphthous ulcers and gastrointestinal symptoms. | ||
| کلیدواژهها | ||
| Behcet’s disease Anti-Saccharomyces cerevisiae antibody Behcet’s disease activity index | ||
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