Effects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 10، دوره 5، شماره 5، آذر و دی 2015، صفحه 450-457 اصل مقاله (440.27 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2015.4547 | ||
| نویسندگان | ||
| Esmaeal Tamaddonfard* 1؛ Sina Tamaddonfard2؛ Salar Pourbaba2 | ||
| 1Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, I.R. Iran | ||
| 2Faculty of Veterinary Medicine, Urmia Azad University, Urmia, I.R. Iran | ||
| چکیده | ||
| Objectives: Crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. In the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. The contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. Materials and Methods: A guide cannula was implanted into the fourth ventricle of brain in anesthetized rats. Orofacial pain was induced by subcutaneous (s.c.) injection of capsaicin (1.5 µg/20 µl) into the right vibrissa pad. The time spent face rubbing/grooming was recorded for a period of 20 min. Locomotor activity was measured using an open-field test. Results: Intra-fourth ventricle injection of crocin (10 and 40 µg/rat) and morphine (10 and 40 µg/rat) and their co-administration (2.5 and 10 µg/rat of each) suppressed capsaicin-induced orofacial pain. The analgesic effect induced by 10 µg/rat of morphine, but not crocin (10 µg/rat), was prevented by 20 µg/rat of naloxone pretreatment. The above-mentioned chemical compounds did not affect locomotor activity. Conclusion: The results of this study showed that the injection of crocin into the cerebral fourth ventricle attenuates capsaicin-induced orofacial pain in rats. The anti-nociceptive effect of crocin was not attributed to the central opioid receptors. | ||
| کلیدواژهها | ||
| Crocin؛ Morphine؛ Naloxone؛ Orofacial pain؛ Rats | ||
| مراجع | ||
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