A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L. | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 2، دوره 5، شماره 6، بهمن و اسفند 2015، صفحه 485-497 اصل مقاله (558.68 K) | ||
| نوع مقاله: Mini Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2015.4430 | ||
| نویسندگان | ||
| Ali Zarei1؛ Saeed Changizi Ashtiyani* 2؛ Soheila Taheri3؛ Majid Ramezani4 | ||
| 1Young Researchers and Elite Club, Abadeh Branch, Islamic Azad University, Abadeh, Iran | ||
| 2Department of Physiology, Arak University of Medical Sciences, Arak, Iran | ||
| 3Education Development Center, Arak University of Medical Sciences, Arak, Iran | ||
| 4Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Many herbaceous plants contain compounds that have biological effects in addition to their medicinal properties. They have compounds with numerous properties, including hypo lipidemic, hypoglycemic, antioxidant, and hepato protective ones, which have been analyzed at different levels. One of these plants, with the scientific name of Berberis vulgaris, is barberry. The most important compounds identified in this plant are berberine, oxycontin, palmatine, bervulcine, berbamine, columbamine, jatrorrhizine, coptisine, and berbamine. In addition to alkaloids, organic acids such as chelidonic acid, citric acid, malic acid, resin, tannin, pectinic, and mucilagic substances are among the ingredients of barberry. In this paper, it was attempted to determine the role and effect of the extract of barberry on various body organs. The results showed that berberine actually increases insulin sensitivity and is capable of inhibiting alpha glucosidase, adipogenesis, and thus acts as an anti-obesity and hypoglycemic agent. Berberine reduces the density of serum cholesterol and triglycerides and can improve the function of liver enzymes, therefore, it can be suggested as a hypo lipidemic and hepato protective plant extract. The hepato protective effects of this extract are probably due to its antioxidant properties. Studies showed that barberry have numerous health benefits, including anti-inflammatory ones. Moreover, it can be used as a medicinal herb to treat a variety of disorders, such as diabetes, liver disease, gallbladder pain, digestive, urinary tract diseases, and gallstones. However, more studies on this issue and doing more focused and intensive researches in this field are recommended. | ||
| کلیدواژهها | ||
| Liver؛ Cholesterol؛ Diabetes؛ Thyroid؛ Barberry؛ Berberis vulgaris | ||
| مراجع | ||
|
Abd El-Wahab AE, Ghareeb DA, Sarhan EE, Abu-Serie MM. 2013.In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetyl cholinesterase, anti-diabetic and anticancer effects.BMC Complement Altern Med, 13:218.
Arayne MS, Sultana N, Bahadur SS. 2007. The berberis story: Berberis vulgarisin therapeutics. Pak J Pharm Sci, 20:83-92.
Arham S, Muhammad S, Yasir A, Liaqat A,. 2012. Berberis lyceum Royle: a review of its traditional uses, phytochemistry and pharmacology. AJPP, 6 : 2346-2353.
Ahangarpour A, Eskandari M, Vaezlari A, Hashemi Tabar M. 2012.Effect of aqueous and hydroalcoholic extract of Beberis vulgaris on insulin secretion from islets of langerhans isolated from male mice. Armaghane-danesh, 17: 289–298.
Arumugam G, Manjula P, Paari N. 2013. Anti diabetic medicinal plants used for diabetes mellitus. JAD,196-200.
Ashraf H, Khaneshi F, Rafiee Raki F, Nejati V. 2013. Evaluation of aqueous extract of Berberis integerrima root on the testis tissue and testosterone levels in streptozotocin induced diabetic rats. Qom Univ Med Sci J, 7: 28-35.
Changizi-Ashtiyani S, Najafi H, Jalalvandi S, Hosseinei F.2013. Protective effects of Rosa canina l fruit extracts on renal disturbances induced by reperfusion injury in rats. IJKD, 7:290-298.
Changizi-Ashtiyani S, Zarei A, Taheri S, Rezaei A,. 2013. A comparative study of hypo lipidemic activities of the extracts of Melissa officinalis and Berberis vulgaris in rats. JMP, 12: 38-47.
Chevallier A: 2001. The encyclopedia of medicinal plants. St Leonards: Dorling Kindersley.
Dashti Z, Shariatifar N, Mohammadi Nafchi A. 2014. Study on antibacterial and antioxidant activity of Berberis vulgaris aqueous extracts from Iran. IntJ Pharm Sci Res, 5:705-708.
Doggrell SA. 2005. Berberine-a novel approach to cholesterol lowering. Expert Opin Investig Drugs,14: 683-685.
Ebrahimi-Mameghani M, Arefhosseini SR, Golzarand M, Aliasgarzadeh A, 2009.Long-term effects of processed Berberis vulgaris on some metabolic syndrome components. IJEM, 11:41-47.
Eshraghi A, Movahedian Ataar A, Asgari S, Naderi GA, 2011.Antioxidant effect of ziziphus vulgaris, portulacaoleracea, Berberis integerima and gundeliatournefortti on lipid peroxidation, hb glycosylation and red blood cell hemolysis. JMP, 10: 80-88.
Fallah Huseini H, Zareei Mahmoudabady A, Ziai SA, Mehrazma M. 2010. The effects of Taraxacumofficinale l. and Berberis vulgarisl. root extracts on carbon tetrachloride induced liver toxicity in rats. JMP,9:45-52.
Fatehi M, Saleh TM, Fatehi-Hassanabad Z, Farrokhfal K. 2005.A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol, 31: 102: 46-52.
Fatehi A, Hassanabad Z, Jafarzadeh M, Tarhini A. 2005. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats. Phytother Res, 19:222-225.
Fukuda K, Hibiya Y, Mutoh M. 1999. Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Med, 65:381-383.
Gao CR, Zhang JQ, Huang QL. 1997. Experimental study on berberin raised insulin sensitivity in insulin resistance rat models. Zhongguo Zhong Xi Yi Jie He Za Zhi, 17: 162-164.
Hanachi P, Othman F, Motalleb G. 2008. Effect of Berberis vulgaris aqueous extract on the apoptosis, sodium and potassium in hepato carcinogenic rats. Iran J Basic Med Sci,11:62-96.
Hermenean A, Popescu C, Ardelean A, Stan M l. 2012. Hepato protective effects of Berberis vulgarisl. extract/β cyclodextrin on carbon tetrachloride-induced acute toxicity in mice. Int J Mol Sci,13:9014-9034.
Imanshahidi M, Hosseinzadeh H.2008.,Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res, 22:999-1012.
Ivanovska N, Philipov S.1996. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immuno pharmacol, 18:553–561.
Javadzadeh SM, Fallah SR. 2012. Therapeutic application of different parts berberis vulgaris. Intl J Agri Crop Sci, 4: 404-408.
Ju SH, Li XY, Zhano BL. 1990. Scavenging effect of berbamine on active oxygen radicals in phorbolester stimulated human poly morphonuclear leukocytes.Biochem Pharmacol, 39: 1673 - 1678.
Kiasalari Z, Khalili M, Ahmadi P. 2011. Effect of alcoholic extract of Berberis Vulgaris fruit on acute and chronic inflammation in male rats. JBMUS, 3.13 :28-35.
Kim WS, Lee YS, Cha SH, Jeong HW. 2009. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. Am J Physiol Endocrinol Metab, 296: 812-819.
Kong W, Wei J, Abidi P, Lin M. 2004. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from stations. Nat Med, 10: 1344-1351.
Kunwar RM, Nepal BK, Kshhetri HB, Rai SK. 2006.Ethnomedicine in Himalaya: a case study from Dolpa, Humla, Jumla and Mustang districts of Nepal. J Ethnobiol Ethnomed, 2:27.
Lee YS, Kim WS, Kim KH, Yoon MJ. 2006. Berberine, a natural plant product, activates AMP-activated protein kinas with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes, 55: 2256–2264.
Leng SH, Lu FE, Xu LJ. 2005. Therapeutic effects of berberine in impaired glucose tolerance rat and its influence on insulin secretion. Acta Pharmacol Sin, 25: 496-502.
Li SY, Ling LH, The BS, Seow WK. 1989. Anti-inflammatory and immuno-suppressive properties of the bis-benzylquinolones: in-vitro comparisons of tetrandrine and berbamine. Int J Immunopharmacol, 11: 395-441.
Lou T, Zhang Z, Xi Z. 2011. Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. inflammation, 34 : 659-67.
Mancini GBJ, Baker S, Bergeron J, Fitchett D. 2011. Diagnosis, prevention, and management of statin adverse effects and intolerance. Can J Cardiol, 27: 635–662.
Matralis AN, Kourounakis AP. 2013.Design, synthesis and evaluation of anti hyperlipidemic agents combining antioxidant and anti-inflammatory activity. Hell J Athero,1:44–52.
Meliani N, El Amine Dib M, Allali H, Tabti B. 2011. Hypoglycaemic effect of Berberis vulgarisl. in normal and streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed,1:468-471.
Minaiyan M, Ghannadi A, Mahzouni P, Jaffari-Shirazi E. 2011. Comparative study of Berberis vulgaris fruit extract and berberine chloride effects on acetic acid-induced colitis in rats. Iran J Pharm Res, 10:97-104.
Mokhber-Dezfuli N, Saeidnia S, Gohar AR, Kurepaz-Mahmoodabadi M. 2014. Phytochemistry and pharmacology of berberis species. Pharmacogn Rev, 8: 8–15.
Motalleb G, Hanachi P, Fauziah O, Asmah R. 2008. Effect of Berberis vulgaris fruit extract on alpha-fetoprotein gene expression and chemical carcinogen metabolizing enzymes activities in hepato carcinogenesis rats. Iran J Cancer Prev,1: 33-44.
Murugesh KS, Yeligar CV, Maiti BC, Maity TK. 2005.Hepatoprotective and antioxidant role of Berberis tinctoria. lesch leaves on paracetamol induced hepatic. Damage in Rats. Iranian J Pharmacol Ther, 4:64-69.
Ozgen M. Saraçoglu O. Nur Gecer E. 2012. Antioxidant capacity and chemical properties of selected barberry (Berberis vulgaris L.) fruits. Hort Environ. Biotechnol, 53:447-451.
Pradhan D, Biswasroy P, Suri. KA. 2013. Isolation of berberine from Berberis Vulgaris Berberis vulgarisl. and standardization of aqueous extract by RP-HPLC. Int J Herb Med,1:106-111.
Rajaian H, Toranjipour H. 2002.Antibacterial effects of the root of Berberis vulgaris .Iranian J Vet Res, 3: 175 - 178.
Rubenfire M, Brook RD, Rosenson RS. 2010. Treating mixed hyper lipidemia and the atherogenic lipid phenotype for prevention of cardiovascular events. Am J Med, 123:892-8.
Saleem R, Ahmad M, Azmat A, Ahmad SI. 2005. Abidi L, Faizi S. Hypotensive activity, toxicology and histopathology of opuntio side-I and methanolic extract of Opuntiadillenii.Biol Pharm Bull, 28:1844-1851.
Shekar Forosh S, Changizi-AshtiyaniS, Akbar Pour B, Attari MM. 2012. The effect of Physalis alkekengi alcoholic extract on thyroid hormones concentrations in rats. Zahedan J Res Med Sci, 13: 1-7.
Shidfar F, Ebrahimi SS, Hosseini S, Heydari I.2012.The effects of Berberis vulgaris fruit extract on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients. Iran J Pharm Res,11:643-652.
Souri EAG, Dehmobed-Sharifabadi A, Nazifi A, Farsam H.2004.Antioxidant activity of sixty plants from Iran. Iran J Pharm Res, 3:55–59.
Shamsa F, Ahmadiani A, Khosrokhavar R. 1999. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J Ethnopharmacol, 64: 161-166.
Singh J, Kakkar P. 2009. Anti hyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. Ethnopharmacol, 123: 22–26.
Taheri S, Zarei A, Changizi-Ashtiyani S, Rezaei A. 2012. Evaluation of the effects of hydroalcoholic extract of Berberis vulgaris root on the activity of liver enzymes in male hypercholesterolemicrats. AJP, 2:153-161.
Tang LQ, Wei W, Chen LM and Liu S. 2006. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol, 108: 109-15.
Tomosaka H, Chin YW, Salim AA, Keller JW. 2008. Antioxidant and cyto protective compounds from Berberis vulgaris (Barberry). Phytother Res, 22: 979-981.
Thirupurasundari CJ, Padmini R, Devaraj SN. 2009. Effect of berberine on the antioxidant status, ultra structural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats. Chem Biol Interact, 177: 190-195.
Timothy CBN, Gregory S, Kelly ND: 1997. Berberine: therapeutic potential of an alkaloid found in several medicinal plants. Altern Med Rev, 2:94–103.
Tsai PL, Tsai TH. 2004. Hepato biliaryexcertion of berberin. Drug Metab Dispos, 32: 405-12.
Wu LY, Ma ZM, Fan XL. 2009. The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells. Cell Stress Chaperones,15: 387–394.
Yin J, Xing H, Ye J. 2008.Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57: 712–717.
Yin J, Gao Z, Liu D, Liu Z, Ye J. 2008. Berberine improves glucose metabolism through induction of glycolysis, Am J Physiol Endocrinol Metab, 294: 148–156.
Yin J, Hu R, Chen M, Tang J. 2002.Effects of berberine on glucose metabolism in vitro. Metabolism, 51: 1439-1443.
Yuan Heng T, Jeanette F, Marnane William C. 1981. Antisecretory effects of berberin in rat ileum. Am J Physiol, 241: 253-8.
Zarei A, Shariati M, Shekar Forosh S, Changizi- Ashtiyani S. 2012. The effect of Physalis alkekengi extract on the physiologic function of organ tissues. Arak Med Univ J, 15: 94-104.[in Persian].
Zarei A, Taheri S, Changizi-Ashtiyani S, Rezaei A. 2015. The study of the effect of the extract Berberis vulgaris root on serum levels of thyroid hormones in rats. ISMJ 2015, 18: 270-279.
Ziai SA, Salar F, Nasri S, Roghani M. 2010. Neuro protective effect of aqueous extract of Berberis vulgarisl. in a model of parkinson’s disease in rat. J Med Plants, 9: 24-33. | ||
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