Motaez, Mahsa, Emami, Seyed Ahmad, Tayarani Najjaran, Zahra. (1394). Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60. , 5(6), 553-559. doi: 10.22038/ajp.2015.4428
Mahsa Motaez; Seyed Ahmad Emami; Zahra Tayarani Najjaran. "Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60". , 5, 6, 1394, 553-559. doi: 10.22038/ajp.2015.4428
Motaez, Mahsa, Emami, Seyed Ahmad, Tayarani Najjaran, Zahra. (1394). 'Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60', , 5(6), pp. 553-559. doi: 10.22038/ajp.2015.4428
Motaez, Mahsa, Emami, Seyed Ahmad, Tayarani Najjaran, Zahra. Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60. , 1394; 5(6): 553-559. doi: 10.22038/ajp.2015.4428

Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60

Avicenna Journal of Phytomedicine
مقاله 8، دوره 5، شماره 6، بهمن و اسفند 2015، صفحه 553-559    اصل مقاله (517.36 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2015.4428
نویسندگان
Mahsa Motaez1؛ Seyed Ahmad Emami2؛ Zahra Tayarani Najjaran* 1
1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad, University of Medical Sciences, Mashhad, Iran.
2Department of Pharmacognosy, School of Pharmacy, Mashhad, University of Medical Sciences, Mashhad, Iran
چکیده
Objective: Scutellaria (Lamiaceae) has been implicated for medicinal purposes both in modern and traditional medicine. Some species of the genus Scutellaria has extensively been studied for anticancer activity. Scutellaria luteo-coerulea (S. luteo-coerulea) is one of the Iranian species of the genus Scutellaria.
Materials and Methods: In the present study, cytotoxic and apoptogenic properties of CH2Cl2, EtOAc, n-BuOH, and H2O fractions of S. luteo-coerulea were investigated on K562. Moreover, HL-60. DNA fragmentation in apoptotic cells were determined by propidium iodide (PI) staining (sub-G1 peak).
Results: Scutellaria luteo-coerulea inhibited the growth of malignant cells in a dose-dependent manner. Among solvent fractions of S. luteo-coerulea, the CH2Cl2 fraction was found to be the most cytotoxic one among others. Sub-G1 peak in flow cytometry histogram of treated cells suggested the induction of apoptosis in S. luteo-coerulea.
Conclusion: Scutellaria luteo-coerulea could be a novel candidate for further analytical elucidation in respect to fine major components responsible for the cytotoxic effect of the plant also clinical evaluations.
کلیدواژه‌ها
Scutellaria luteo-coerulea؛ Cytotoxicity؛ Apoptosis؛ Lamiaceae
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