Interaction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male Wistar rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 13، دوره 18، شماره 4، تیر 2015، صفحه 398-403 اصل مقاله (1.72 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2015.4290 | ||
| نویسندگان | ||
| Zeynab Sarlak1؛ Shahrbanoo Oryan* 1؛ Mehrnoush Moghaddasi2 | ||
| 1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran | ||
| چکیده | ||
| Objective(s): The cholinergic system plays an important role in learning and memory. This study investigated the effects of curcumin (turmeric extract) and the cholinergic system and their interaction on memory retention of passive avoidance learning in adult male Wistar rats. Materials and Methods: At first, an injection cannula was implanted in right ventricles of the animals. One week after the surgery, the animals were trained with a shuttle box set up. Post-training, injections were performed in all experiments. Administration of curcumin increased memory retention. Also administrations of nicotine and pilocarpine, the cholinergic receptor agonists, increased memory retention, while it is decreased by succinylcholine and scopolamine, the cholinergic receptor antagonists. Then co-administration of curcumin and cholinergic drugs were performed. Intraperitoneal and intracerebroventricular injections were applied for the curcumin and cholinergic drugs, respectively. Results: Co-administration of curcumin (45 mg/kg) with a low dose of nicotine (0.1 µg/rat) or pilocarpine (0.5 µg/rat) increased memory retention significantly. Effects of succinylcholine (0.01, 0.1 and 0.5 µg/rat) or scopolamine (0.1, 1 and 5 µg/rat) were attenuated by curcumin markedly (45 mg/kg). Conclusion: The results suggest that curcumin has a close interaction with cholinergic system in memory retention process. | ||
| کلیدواژهها | ||
| Cholinergic system؛ Curcumin؛ Memory retention؛ Step through latency | ||
| مراجع | ||
|
1. Carew TJ, Hawkins RD, Kandel ER. Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica. Science 1983; 219: 397-400.
2. Atri A, Sherman S, Norman KA, Kirchhoff BA, Hasselmo ME. Stern CE. Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associated memory task. Behav Neurosci 2004; 118:223-236.
3. Eidi A, Eidi M, Mahmoodi G, Oryan SH. Effect of vitamin E on memory retention in rats: Possible involvement of cholinergic system. Eur Neuropharmacol 2006; 16:101-106.
4. Gupta R, Gupta L, Mediratta P, Bhattacharya SK. Effect of resveratrol on scopolamine-induced cognitive impairments in mice. Pharmacol Rep 2012; 64:438-444.
5. Kruk M, Tendera K, Bioela G. Memory-related effect of cholinergic receptor ligands in mice as measured by elevated plus maze test. Pharmacol Rep 2011; 63:1372-1382.
6. Power AE, Vazdarjanova A, McGaugh JL. Muscarinic cholinergic influences in memory consolidation. Neurobiol Learn Mem 2003; 80:178-193.
7. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 1997; 20:154-159.
8. Hamaguchi T, Ono K, Yamada M. Curcumin and Alzheimer's disease. CNS Neurosci & Therapeutics 2010; 16:285-297.
9. Blokland A. Acetylcholine: a neurotransmitter for learning and memory? Brain Res Rev 1995; 21:285-300.
10. Noorafshan A, Asadi-Golshan R, Karbalay-Doust S, Abdollahifar MA, Rashidiani-Rashidabadi A. Curcumin, the main part of turmeric, prevents learning and memory changes induced by sodium metabisulfite, a preservative agent, in rats. Exp Neurobiol 2013; 22:23-30.
11. Aggarwal BB, Sandaram C, Malani N, Ichikawa H. Curcumin: The Indian solid gold. Adv Exp Med Biol 2007; 595:1-75.
12. Eptein J, Sanderson IR, Macdonald TT. Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr 2010; 103:1545-1557.
13. Noorafshan A, Ashani-Esfahani S. A review of therapeutic effects of curcomin. Curr Pharm 2013; 19:2032-2046.
14. Pan R, Qiu S, Lu DX, Dong J. Curcumin improves learning and memory ability and its neuroprotective mechanicm in mice. Chin Med J 2008; 121:832-839.
15. Kim DS, Park SY, Kim JY. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from Aβ (1-42) insult. Neurosci Lett 2001; 303: 57-61.
16. Zhu YG, Chen XC, Chen ZZ, Zeng YQ, Shi GB, Su YH, et al. Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons. Acta Pharmacol Sin 2004; 25: 1606-1612.
17. Tamaddonfard E, Farshid AA, Asri-Rezaee S, Javadi Sh, Khosravi V, et al. Croin improved learning and memory impairments in streptozotocin-induced diabetic rats. Iran J Basic Med Sci 2013; 16:91-100.
18. Sheibani V, Afarinesh M, Hajializadeh Z, Abbasnejad M, Haghpanah T, et al. Evaluation of Origanum vulgar L. ssp. Viridis leaves extract effect on discrimination learning and LTP induction in the CA1 region of the rat hippocampus. Iran J Basic Med Sci 2010; 14:177-184.
19. Qiao S, Li W, Tsubouchi R, Haneda M, Murakami K, Takeuchi F, et al. Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages. Free Radic Res 2005; 39:995-1003.
20. Tran MH, Yamada K, Nakajima A, Mizuno M, Kamei H, et al. Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-induced cholinergic dysfunction. Mol Psychiaty 2003; 8:407-412.
21. Blomhoff R. Antioxidants and oxidative stress. Tiddssr Nor Laegoforen 2004; 124:1643-1645.
22. Hu D, Serrano F, Oury TD, Klann E. Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase. J Neurosci 2006; 26:3933-3941.
23. Watson JB, Arnold MM, Ho YS, O'Dell TJ. Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes. J Neurosci Res 2006; 84:1564-1574.
24. Blumenthal M, Goldberg A, Brinkman J. Herbal Medicine: the expended commission E monographs. Newton: Integra Med Com; 2000.
25. Garcia–Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzhimer mouse model. J Neurochem 2007; 102:1095-1104.
26. Akram M, Shahab-uddin, Ahmad A, Khan U, Hanna A, et al. Curcuma longa and curcumin: a review article. Rom J Biol –Plant Biol 2010; 55:65-70.
27. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. (2nd ed). San Diego: Acadamic Press; 1986.
28. Kumar P, Padi SS, Nadiu PS, Kumar A. Possible neuroprotective machanisms of curcumin in attenuating
3-nitropropionic acid-induced neurotoxicity. Methods Find Exp Clin Pharmacol 2007; 29:19-26.
29. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin, a short review. Life Sci 2006; 78:2081-2087.
30. Bengmark S. Curcumin, a toxic antioxidant and natural NFkappaB, cyclooxygenase-2, lippoxygenase, and inducible nitric oxide synthase inhibitor: A shield against acute and chronic disease. JPEN J Parenter Enteral Nutr 2006; 30:45-51.
31. Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res 2005; 2:131-136.
32. Yadav Rs, Sankwar ML, Shula PK, Chandra R, Pant AB, Islam F, Khanna V. Attenuation of arsenic neurotoxicity by curcumin in rats. Toxical Appl Pharmacol 2009; 240:367-376.
33. Caril M, Balducci C, Samanin R. Low doses of 8-OH-DPAT prevent the impairment of spatial learning caused by intra-hippocampal scopolamine through 5-HT (1A) receptors in the dorsal raphe. Br J Pharmacol 2000; 131:375-381.
34. Khajepour L, Rezayof A, Zarrindast MR. Involvement of dorsal hippocampal nicotinic receptors ion the effect of morphine on memory retrieval in passive avoidance task. Eur J Pharmacol 2008; 584:343-351.
35. Parfitt G, Campos RC, Barbosa AK, Koth AP, Barros DM. Paticipation of hippocampal cholinergic system in memory persistence for inhibitory avoidance in rats. Neurobiol Learn Mem 2012; 97:183-188.
36. Ramkrez MJ, Honer WG, Minger SL, Francis PT. Changes in hippocampal SNAP-25 expression following afferent lessions. Brain Res 2004; 997:133-135.
37. McGaugh JL. The amygdala modulates the console-dation of memories of emotionally arousing experi-ences. Annu Rev Neurosci 2004; 27:1-28.
38. Ali EH, Arafa NM. Comparative protective action of curcumin, memantine and diclofenac against scopolamine-induced memory dysfunction. Fitoterapia2011; 82:601-608.
39. Dong J, Lu DX, Pan R, Tang HM. Effect and mechanism of curcumin on learning and memory dysfunction induced by gp120 in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008; 24:328-331. | ||
|
آمار تعداد مشاهده مقاله: 1,984 تعداد دریافت فایل اصل مقاله: 1,385 |
||