Rajabi Mashhadi, Mohammadtaghi, Bagheri, Reza, Abdollahi, Abbas, Ghamari, Mohammad Javad, shahidsales, soudabeh, Salehi, Maryam, Shahkaram, Reza, Majidi, Mohamad Reza, Sheibani, Shima. (1394). The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery. , 27(4), 279-284. doi: 10.22038/ijorl.2015.4247
Mohammadtaghi Rajabi Mashhadi; Reza Bagheri; Abbas Abdollahi; Mohammad Javad Ghamari; soudabeh shahidsales; Maryam Salehi; Reza Shahkaram; Mohamad Reza Majidi; Shima Sheibani. "The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery". , 27, 4, 1394, 279-284. doi: 10.22038/ijorl.2015.4247
Rajabi Mashhadi, Mohammadtaghi, Bagheri, Reza, Abdollahi, Abbas, Ghamari, Mohammad Javad, shahidsales, soudabeh, Salehi, Maryam, Shahkaram, Reza, Majidi, Mohamad Reza, Sheibani, Shima. (1394). 'The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery', , 27(4), pp. 279-284. doi: 10.22038/ijorl.2015.4247
Rajabi Mashhadi, Mohammadtaghi, Bagheri, Reza, Abdollahi, Abbas, Ghamari, Mohammad Javad, shahidsales, soudabeh, Salehi, Maryam, Shahkaram, Reza, Majidi, Mohamad Reza, Sheibani, Shima. The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery. , 1394; 27(4): 279-284. doi: 10.22038/ijorl.2015.4247

The Effect of Neoadjuvant Therapy on Early Complications of Esophageal Cancer Surgery

Iranian Journal of Otorhinolaryngology
مقاله 5، دوره 27، شماره 4، 2015، صفحه 279-284    اصل مقاله (217.23 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2015.4247
نویسندگان
Mohammadtaghi Rajabi Mashhadi1؛ Reza Bagheri* 2؛ Abbas Abdollahi3؛ Mohammad Javad Ghamari1؛ soudabeh shahidsales4؛ Maryam Salehi5؛ Reza Shahkaram1؛ Mohamad Reza Majidi6؛ Shima Sheibani2
1Endoscopic & Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2Cardio-Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4Department of Radiotherapy & oncology, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Introduction:
Early diagnosis and appropriate treatment is required in esophageal cancer due to its invasive nature. The aim of this study was to evaluate early post-esophagectomy complications in patients with esophageal cancer who received neoadjuvant chemoradiotherapy (NACR).
 
Materials and Methods:
This randomized clinical trial was carried out between 2009 and 2011. Patients with lower-third esophageal cancer were randomly assigned to one of two groups. The first group consisted of 50 patients receiving standard chemoradiotherapy (Group A) and then undergoing surgery, and the second group consisted of 50 patients undergoing surgery only (Group B). Patients were evaluated with respect to age, gender, clinical symptoms, type of pathology, time of surgery, perioperative blood loss, and number of lymph nodes resected as well as early post-operative complicate including leakage at the anastomosis site, chylothorax and pulmonary complications, hospitalization period, and mortality rate within the first 30 days after surgery.
 
Results:
The mean age of patients was 55 years. Seventy-two patients had squamous cell carcinoma (SCC) and 28 patients had adenocarcinoma (ACC). There was no significant difference between the two groups with respect to age, gender, time of surgery, complications including anastomotic leakage, chylothorax, pulmonary complications, cardiac complications, deep venous thrombosis (DVT), or mortality. However, there was a significant difference between the two groups regarding hospital stay, time of surgery, perioperative blood loss, and number of lymph nodes resected.
 
Conclusion: 
The use of NACR did not increase early post-operative complications or mortality among patients with esophageal cancer. 
کلیدواژه‌ها
Esophageal Cancer؛ Neoadjuvant Therapy؛ Surgery
مراجع
آمار
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