Abbasnezhad, Abbasali, Niazmand, Saeed, Mahmoudabady, Maryam, Soukhtanloo, Mohammad, Rezaee, Seyed Abdolrahim, Mousavi, Seyed Mojtaba. (1394). Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta. , 6(1), 67-76. doi: 10.22038/ajp.2016.4187
Abbasali Abbasnezhad; Saeed Niazmand; Maryam Mahmoudabady; Mohammad Soukhtanloo; Seyed Abdolrahim Rezaee; Seyed Mojtaba Mousavi. "Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta". , 6, 1, 1394, 67-76. doi: 10.22038/ajp.2016.4187
Abbasnezhad, Abbasali, Niazmand, Saeed, Mahmoudabady, Maryam, Soukhtanloo, Mohammad, Rezaee, Seyed Abdolrahim, Mousavi, Seyed Mojtaba. (1394). 'Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta', , 6(1), pp. 67-76. doi: 10.22038/ajp.2016.4187
Abbasnezhad, Abbasali, Niazmand, Saeed, Mahmoudabady, Maryam, Soukhtanloo, Mohammad, Rezaee, Seyed Abdolrahim, Mousavi, Seyed Mojtaba. Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta. , 1394; 6(1): 67-76. doi: 10.22038/ajp.2016.4187

Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta

Avicenna Journal of Phytomedicine
مقاله 7، دوره 6، شماره 1، فروردین و اردیبهشت 2016، صفحه 67-76    اصل مقاله (512.56 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2016.4187
نویسندگان
Abbasali Abbasnezhad1؛ Saeed Niazmand* 2؛ Maryam Mahmoudabady3؛ Mohammad Soukhtanloo4؛ Seyed Abdolrahim Rezaee5؛ Seyed Mojtaba Mousavi1
1Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective: Diabetes is an important risk factor for cardiovascular events. The great percent of morbidity in patients with diabetes is due to endothelial dysfunction. The present study investigated the effects of hydroalcholic extract of Nigella sativa (N. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat.
Materials and Methods: Rats were divided into six experimental groups (control, untreated STZ-diabetic, and N. sativa hydroalcholic extract or metformin-treated diabetic rats). Treated rats received N. sativa extract (100, 200, and 400 mg/kg) or metformin (300 mg/kg) by gavage, daily for 6 weeks.
Isolated rat thoracic rings were mounted in an organ bath system then contractile and dilatation responses induced by phenylephrine (PE), acetylcholine (ACh), potassium chloride (KCl), and sodium nitroprusside (SNP) were evaluated in different situations.
Results: The lower concentrations of N. sativa seed extract (DE 100 and DE 200) and metformin significantly reduced the contractile responses to higher concentrations of PE (10-6 - 10-5 M) compared to diabetic group (pThe relaxation response to Ach 10-8M, was increased in DE 200 and metformin groups compared to diabetic group (p<0.05). The relaxation responses to Ach 10-7 - 10-5Mwere significantly higher in all treated groups compared to diabetic group (pConclusion: Chronic administration of N. sativa seed extract has a significant hypoglycemic effect and improves aortic reactivity to vasoconstrictor and vasodilator agents in STZ-induced diabetic rats.
کلیدواژه‌ها
Diabetes Mellitus؛ Nigella Sativa؛ Endothelial dysfunction؛ Isolated aorta؛ Rat
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