Malekifard, Farin, Delirezh, Nowruz, Hobbenaghi, Rahim, Malekinejad, Hassan. (1393). Immunotherapeutic effects of pentoxifylline in type 1 diabetic mice and its role in the response of T-helper lymphocytes. , 18(3), 246-251. doi: 10.22038/ijbms.2015.4125
Farin Malekifard; Nowruz Delirezh; Rahim Hobbenaghi; Hassan Malekinejad. "Immunotherapeutic effects of pentoxifylline in type 1 diabetic mice and its role in the response of T-helper lymphocytes". , 18, 3, 1393, 246-251. doi: 10.22038/ijbms.2015.4125
Malekifard, Farin, Delirezh, Nowruz, Hobbenaghi, Rahim, Malekinejad, Hassan. (1393). 'Immunotherapeutic effects of pentoxifylline in type 1 diabetic mice and its role in the response of T-helper lymphocytes', , 18(3), pp. 246-251. doi: 10.22038/ijbms.2015.4125
Malekifard, Farin, Delirezh, Nowruz, Hobbenaghi, Rahim, Malekinejad, Hassan. Immunotherapeutic effects of pentoxifylline in type 1 diabetic mice and its role in the response of T-helper lymphocytes. , 1393; 18(3): 246-251. doi: 10.22038/ijbms.2015.4125

Immunotherapeutic effects of pentoxifylline in type 1 diabetic mice and its role in the response of T-helper lymphocytes

Iranian Journal of Basic Medical Sciences
مقاله 6، دوره 18، شماره 3، 2015، صفحه 246-251    اصل مقاله (1.47 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2015.4125
نویسندگان
Farin Malekifard1؛ Nowruz Delirezh* 1؛ Rahim Hobbenaghi2؛ Hassan Malekinejad3
1Department of Microbiology, School of Veterinary Medicine, Urmia University, Urmia, Iran
2Department of Pathobiology, School of Veterinary Medicine, Urmia University, Urmia, Iran
3Department of Pharmacology & Toxicology, School of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Objective(s):Pentoxifylline is an immunomodulatory and anti-inflammatory agent and is used in vascular disorders. It has been shown that pentoxifylline inhibits proinflammatory [d1] cytokines production. The purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice.
Materials and Methods: Diabetes was induced by multiple low dose of streptozotocin (MLDS) injection (40 mg/kg/day for 5 consecutive days) in male C57BL/6 mice. After induction of diabetes, mice were treated with pentoxifylline (100 mg/kg/day IP) for 21 days. Blood glucose levels and plasma levels of insulin were measured. Splenocytes were tested for proliferation by MTT test and cytokine production by ELISA.
Results: Pentoxifylline treatment prevented hyperglycemia and increased plasma insulin levels in the diabetic mice. Aside from reducing lymphocyte proliferation, pentoxifylline significantly inhibited the production of proinflammatory interleukin 17 (IL-17) as well as interferon gamma (IFN-γ), while increased anti-inflammatory cytokine IL-10 as compared with those in MLDS group (diabetic control group).
Conclusion: These findings indicate that pentoxifylline may have therapeutic effect against the autoimmune destruction of the pancreatic beta-cells during the development of MLDS-induced type 1 diabetes in mice.
کلیدواژه‌ها
Cytokine؛ Pentoxifylline؛ Type 1 Diabetes Mellitus
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