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Jafariye, Arash, Hajimohammadi, Fatemeh, Etemadi Al-e-Agha, Afshar, Salavatipour, Azadeh, Rajati Haghi, Mohsen. (1389). The efficacy of clonidine on intraoperative bleeding in middle ear microsurgery. , 21(5758), 121-126. doi: 10.22038/ijorl.2010.400
Arash Jafariye; Fatemeh Hajimohammadi; Afshar Etemadi Al-e-Agha; Azadeh Salavatipour; Mohsen Rajati Haghi. "The efficacy of clonidine on intraoperative bleeding in middle ear microsurgery". , 21, 5758, 1389, 121-126. doi: 10.22038/ijorl.2010.400
Jafariye, Arash, Hajimohammadi, Fatemeh, Etemadi Al-e-Agha, Afshar, Salavatipour, Azadeh, Rajati Haghi, Mohsen. (1389). 'The efficacy of clonidine on intraoperative bleeding in middle ear microsurgery', , 21(5758), pp. 121-126. doi: 10.22038/ijorl.2010.400
Jafariye, Arash, Hajimohammadi, Fatemeh, Etemadi Al-e-Agha, Afshar, Salavatipour, Azadeh, Rajati Haghi, Mohsen. The efficacy of clonidine on intraoperative bleeding in middle ear microsurgery. , 1389; 21(5758): 121-126. doi: 10.22038/ijorl.2010.400

The efficacy of clonidine on intraoperative bleeding in middle ear microsurgery

Iranian Journal of Otorhinolaryngology
مقاله 3، دوره 21، شماره 5758، شهریور 2010، صفحه 121-126
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2010.400
نویسندگان
Arash Jafariye1؛ Fatemeh Hajimohammadi1؛ Afshar Etemadi Al-e-Agha1؛ Azadeh Salavatipour2؛ Mohsen Rajati Haghi3
1Department of anesthesiology, Amir Alam Hospital, North Saadi Ave, Tehran, Iran
2General Practitioner
3Assistant ear, throat, nose, ears Research Center, Mashhad University of Medical Sciences, throat and nose
چکیده
Introduction: The aim of this study was to evaluate the efficacy of clonidine on intraoperative bleeding in middle ear microsurgery.
Materials and Methods: This prospective double-blinded clinical trial was performed on 51 patients (ASA I, II), aged 15-60 year undergoing middle ear microsurgery. They were randomly assigned to receive either 200 micrograms clonidine per oral or placebo 90 minutes prior the operation in a double blind condition. Intraoperative bleeding was assessed on a four-point scale. Systemic blood pressure and heart rate were measured before and during surgery. Intraoperative bleeding, antihypertensive requirements, cardiovascular changes after intubation, post operative bleeding and reoperations were compared between two groups. 
Results: Clonidine group had a better bloodless surgical field than placebo group (P<0.05). Intraoperative consumption of antihypertensive drugs to reduce bleeding were significantly lower in the clonidine group (P<0.05). Heart rate and blood pressure were lower in the clonidine group, but their differences were not statistically significant. There was no significant difference in post operative bleeding and the rate of graft failure (reoperation) between two groups.
Conclusion: Clonidine as a premedication can provide a bloodless surgical field and can improve surgical visibility during microsurgery.
کلیدواژه‌ها
Bleeding؛ Clonidine؛ Microsurgery
آمار
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