Crocin alleviates the local paw edema induced by histamine in rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 7، دوره 2، شماره 2، خرداد 2012، صفحه 97-104 اصل مقاله (2.84 M) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2012.40 | ||
| نویسندگان | ||
| Esmaeal Tamaddonfard* 1؛ Amir Abbas Farshid2؛ Leila Hosseini1 | ||
| 1Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran | ||
| 2Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran | ||
| چکیده | ||
| Objective: Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. Materials and Methods: Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. The thickness of paw was measured at 1 h before and 1, 2, 3 h after injection of histamine, using a fine caliper. The number of neutrophils in paw tissue sections was counted 3 h after intraplantar injection of histamine. Results: Intraperitoneal injection of crocin at doses of 100 and 200 mg/kg and chlorpheniramine at a dose of 10 mg/kg significantly (p<0.05) decreased both paw thickness and infiltration of neutrophils in paw tissues. In a combined treatment, intraperitoneal injection of an effective dose of crocin (100 mg/kg) with an ineffective dose of chlorpheniramine (2.5 mg/kg) produced a more documented response in comparison with crocin (100 mg/kg) and chlorpheniramine (2.5 mg/kg) used alone. Conclusion: The results suggested that both crocin and chlorpheniramine suppressed histamine-induced local paw edema. Moreover, histamine H1 receptors function may be affected by crocin. | ||
| کلیدواژهها | ||
| Crocin؛ Chlorpheniramine؛ Histamine؛ Paw edema؛ Rats | ||
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