Hadi, Vahid, Kheirouri, Sorayya, Alizadeh, Mohammad, Khabbazi, Alireza, Hosseini, Hossein. (1394). Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. , 6(1), 34-43. doi: 10.22038/ajp.2016.3910
Vahid Hadi; Sorayya Kheirouri; Mohammad Alizadeh; Alireza Khabbazi; Hossein Hosseini. "Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial". , 6, 1, 1394, 34-43. doi: 10.22038/ajp.2016.3910
Hadi, Vahid, Kheirouri, Sorayya, Alizadeh, Mohammad, Khabbazi, Alireza, Hosseini, Hossein. (1394). 'Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial', , 6(1), pp. 34-43. doi: 10.22038/ajp.2016.3910
Hadi, Vahid, Kheirouri, Sorayya, Alizadeh, Mohammad, Khabbazi, Alireza, Hosseini, Hossein. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. , 1394; 6(1): 34-43. doi: 10.22038/ajp.2016.3910

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

Avicenna Journal of Phytomedicine
مقاله 4، دوره 6، شماره 1، فروردین و اردیبهشت 2016، صفحه 34-43    اصل مقاله (615.92 K)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2016.3910
نویسندگان
Vahid Hadi1؛ Sorayya Kheirouri* 1؛ Mohammad Alizadeh1؛ Alireza Khabbazi2؛ Hossein Hosseini3
1Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Agriculture, Barij Essence Pharmaceutical Company, Kashan, Iran
چکیده
Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arthritis (RA).
Materials and Methods: Forty-two patients with RA were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. Subjects in intervention group received two capsules, 500 mg each, of Nigella sativa oil, each day for 8 weeks. The other group consumed two capsules as placebo per day for the same period of time. Serum TNF-α, IL-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial.
Results: The serum level of IL-10 was increased in the Nigella sativa group (p<0.01). Moreover, treatment with Nigella sativa led to significant reduction of serum MDA and NO compared with baseline (p<0.05). There were no significant differences in the TNF-α, SOD, catalase, and TAS values between or within the groups, before and after the intervention (p>0.05).
Conclusions: This study indicates that Nigella sativa could improve inflammation and reduce oxidative stress in patients with RA. It is suggested that Nigella sativa may be a beneficial adjunct therapy in this population of patients
کلیدواژه‌ها
Nigella Sativa؛ Rheumatoid arthritis؛ Oxidative stress؛ IL-10؛ TNF-α
مراجع
آمار
تعداد مشاهده مقاله: 30,765
تعداد دریافت فایل اصل مقاله: 13,305