Cancer therapy with phytochemicals: evidence from clinical studies | |||
| Avicenna Journal of Phytomedicine | |||
| مقاله 2، دوره 5، شماره 2، خرداد و تیر 2015، صفحه 84-97 اصل مقاله (654.59 K) | |||
| نوع مقاله: Review Article | |||
| شناسه دیجیتال (DOI): 10.22038/ajp.2015.3872 | |||
| نویسندگان | |||
| Ahmad Ghorbani* 1؛ Azar Hosseini2 | |||
| 1Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, | |||
| 2Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences | |||
| چکیده | |||
| Cancer is still one of the major causes of mortality in both developing and developed countries. At this time, in spite of intensive interventions, a large number of patients have poor prognosis. Therefore, the effort for finding new anticancer agents with better efficacy and lesser side effects has continued. According to the traditional recommendations and experimental studies, numerous medicinal plants have been reported to have anticancer effect. Also antiproliferative, proapoptotic, antimetastatic and antiangiogenic effects of several phytochemicals have been shown with in vitro experiments or animal studies. However, only a small number of them were tested in cancerous patients and limited evidence exists on their clinical effectiveness. Also, regarding some phytochemicals, only beneficial effects on cancer-related symptoms or on quality of life have been reported and no positive results exist on their antitumor actions. In this review we focus on phytochemicals that their beneficial effects on various types of cancer are supported by clinical trials. Based our literature search, curcumin, green tea, resveratrol and Viscum album had satisfactory instances of clinical evidence for supporting their anticancer effects. The main findings on these phytochemicals are summarized and discussed. | |||
| کلیدواژهها | |||
| Cancer؛ Phytochemical؛ Plant؛ Tumor | |||
| مراجع | |||
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Aggrawal B, Bhardwaj A, Aggrawal R, Seeram NP, Hishodia S, Takada Y. 2004. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res, 24: 2783-2840.
Alinejad B, Ghorbani A, Sadeghnia HR. 2013. Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death. Avicenna J Phytomed, 3: 321-328.
Anastas JN, Moon RT. 2013. WNT signalling pathways as therapeutic targets in cancer. Nature Reviews Cancer, 13: 11-26.
Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL. 2007. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol, 224: 274- 283.
Bao PP, Lu W, Cui Y, Zheng Y, Gu K, Chen Z, Zheng W, Shu XO. 2012. Ginseng and Ganoderma lucidum use after breast cancer diagnosis and quality of life: a report from the shanghai breast cancer survival study. PLoS ONE, 7: e39343.
Barton DL, Soori GS, Bauer BA, Sloan JA, Johnson PA. 2010. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer, 18: 179-187.
Bettuzzi S, Brausi M, Rizzi Federica, Castagnetti G, Peracchia G, Corti A. 2006. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res, 66: 1234-1240.
Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. 2013. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther, 12: 312-22.
Chacko SM, Thambi PT, Kuttan R, Nishigaki I. 2010. Beneficial effects of green tea: A literature review. Chin Med, 5: 13.
Chahar MK, Sharma N, Dobhal MP, Joshi YC. Flavonoids: a versatile source of anticancer drugs. Pharmacogn Rev 2011; 5: 1-12.
Chen HW, Huang HC. 1998. Effect of Curcumin on cell cycle progression and apoptosis in smooth muscle cells. Br J Pharmacol, 124: 1029-1040.
Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res, 21: 2895-2900.
Cheon SH, Kim KS, Kim S, Jung HS, Choi WC, Eo WK. 2011. Efficacy and safety of Rhus verniciflua stokes extracts in patients with previously treated advanced non-small cell lung cancer. Forschende Komplementarmedizin, 18: 77-83.
Choan E, Segal R, Jonker D, Malone S, Reaume N, Eapen L, Gallant V. 2005. A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach. Urol Oncol, 23: 108-113.
Coca S, Perez-Piqueras J, Martinez D, Colmenarejo A, Saez MA, Vallejo C, Martos JA, Moreno M. 1997. The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer, 79: 2320-8.
Cui Y, Shu XO, Gao YT, Cai H, Tao MH, Zheng W. 2006. Association of Ginseng use with survival and quality of life among breast cancer patients. Am J Epidemiol, 163: 645-653.
De la Taille A, Hayek OR, Buttyan R, Bagiella E, Burchardt M, Katz AE. 1999. Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: a preliminary investigation on human cell lines and patients. BJU Int, 84: 845-850.
Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL. 2008. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res, 14: 4491-4499.
Dropcho EJ. 2011. The neurologic side effects of chemotherapeutic agents. Continuum (Minneap Minn) 17: 95-112.
Fleischauer AT, Poole Ch, Arab L. 2000. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr, 72:1047-1052.
Gao YT, McLaughlin JK, Blot WJ, Ji BT, Dai Q, Fraumeni JF Jr. 1994. Reduced risk of esophageal cancer associated with green tea consumption. J Natl Cancer Int, 86: 855-858.
Gao Y, Zhou S, Jiang W, Huang M, Dai X. 2003. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest, 32:201-15.
Ghorbani A, Asadpour E, Sadeghnia HR. 2014. Mechanism of protective effect of lettuce against glucose/serum deprivation-induced neurotoxicity. Nutr Neurosci, in press.
Ghorbani A. 2013b. Best herbs for managing diabetes: A review of clinical studies. Braz J Pharm Sci, 49: 413-422.
Ghorbani A. Phytotherapy for diabetic dyslipidemia: evidence from clinical trials. Clin Lipidol, 2013a; 8: 311-319.
Grossarth-Maticek R, Kiene H, Baumgartner SM, Ziegler R. 2001. Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med, 7: 57-66.
Gupta SC, Patchva S, Aggarwal BB. 2013. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J, 5: 195-218.
Guzma´n M, Duarte MJ, Bla´zquez C, J Ravina, MC Rosa, Galve-Roperh I, Sa´nchez C, Velasco G, Gonza´lez-Feria L. 2006. A pilot clinical study of 9-tetrahydrocannabinol in patients with recurrent glioblastoma multiformeBr J Cancer, 95: 197-203.
Hagag AA, Abd Elaal AM, Elsheik A, Elzamarany AE. 2013. Protective effect of Nigella Sativa oil against methotrexate induced hepatotoxicity in children with acute lymphoblastic leukemia. J Leuk, 1: 123.
Hajzadeh MR, Tavakkol-Afshari J, Ghorbani A, Shakeri MT. 2006. The effects of aqueous extract of garlic (Allium sativum L.) on laryngeal cancer cells (Hep-2) and L929 cells in vitro. J Med Plants, 5: 41-48.
Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ. 2011. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res, 4: 1419-1425.
Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, Fukuda S, Morimoto K. 2006. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr, 136: 816S–820S.
Jang HS, Kook SH, Son YO. 2005. Flavonoids purified from Rhus verniciflua stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochimica Biophysica Acta, 1726: 309-316.
Jatoi A, Ellison N, Burch PA, Sloan JA, Dakhil SR, Novotny P, Tan W, Fitch TR, Rowland KM, Young CY, Flynn PJ. 2003. A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer, 97:1442-1446.
Ji BT, Chow WH, Hsing AW, McLaughlin JK, Dai Q, Gao YT, Blot WJ, Fraumeni JF Jr. 1997. Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer, 27: 255-258.
Jian L, Xie LP, Lee AH, Binns CW. 2004.Protective effect of green tea against prostate cancer: a case-control study in southeast China. Int Journal Cancer, 108: 130-135.
Jianhua S, Kwon YS, Yu CY, Kim M, Kim T, Kim JS, Chun WJ. 2010. Rhus verniciflua stokes flavonoid extracts have anti-oxidant, anti-microbial and α-glucosidase inhibitory effect. Food Chem, 120: 539-543.
Kienle GS Berrino F, Bussing A, Portalupi E, Rosenzweig S, Kiene H. 2003. A systematic review on controlled clinical trials. Eur J Med Res, 8: 109-119.
Kim JH, Park CY. 2006. Effects of Sun Ginseng on subjective quality of life in cancer patients: a double-blind, placebo-controlled pilot trial. J Clin Pharm Ther, 31, 331-334.
Kim KH, Moon E, Choi SU, Kim SY, Lee KR. 2013. Polyphenols from the bark of Rhus verniciflua and their biological evaluation on antitumor and anti-inflammatory activities. Phytochemistry, 92: 113-121.
Kleeberg UR, Suciu S, Bröcker EB, Ruiter DJ, Chartier C, Liénard D, Marsden J, Schadendorf D, Eggermont AM; EORTC Melanoma Group in cooperation with the German Cancer Society (DKG). 2004. Final results of the EORTC 18871/DKG 80-1 randomised phase III trial. rIFN-alpha2b versus rIFN-gamma versus ISCADOR M versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasis. Eur J Cancer, 40: 390-402.
Lee JC, Lee KY, Kim J. 2004. Extract from Rhus verniciflua stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem Toxicol, 42: 1383–1388.
Lee S, Kim K, Jung H, Lee S, Cheon S, Kim S, Eo W, Choi W. 2011. Efficacy and safety of standardized allergen-removed Rhus verniciflua Stokes extract in patients with advanced or metastatic pancreatic cancer: a Korean single-center experience. Oncol, 81: 312-318.
Lee SH, Choi WC, Kim KS, Park JW, Lee SH, Yoon SW. 2010b. Shrinkage of gastric cancer in an elderly patient who received Rhus verniciflua stokes extract. J Altern Complement Med, 16: 497-500.
Lee SH, Choi WC, Yoon SW. 2009a. Impact of standardized Rhus verniciflua stokes extract as complementary therapy on metastatic colorectal cancer: a Korean single-center experience. Integr Cancer Ther, 8: 148–152.
Lee SH, Kim KS, Choi WC, Yoon SW. 2009b. The concurrent use of Rhus verniciflua stokes as complementary therapy with second or more line regimen on advanced non-small-cell lung cancer: case series. The Journal of Korean Oriental Medicine 30:112-117.
Lee SK, Jung HS, Eo WK, Lee SY, Kim SH, Shim BS. 2010a. Rhus verniciflua stokes extract as a potential option for treatment of metastatic renal cell carcinoma: report of two cases. Ann Oncol, 21:1383-1385.
Li QY, Zu YG, Shi RZ, Yao LP. 2006. Review camptothecin: current perspectives. Curr Med Chem, 13: 2021-2039.
Lissoni P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G, Mora A, Porro G. 2009. A randomized Study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo, 23: 171-176
Monsuez J, Charniot JC, Vignat N, Artigou JY. 2010. Cardiac side-effects of cancer chemotherapy. Inter J Cardiol, 144: 3–15.
Mortazavian SM, Ghorbani A, Hesari TG. 2012. Effect of hydro-alcoholic extract of Viola tricolor and its fractions on proliferation of uterine cervix carcinoma cells. Iran J Obst Gyncol Infertil, 15: 9-16.
Mortazavian SM, Ghorbani A. 2012. Antiproliferative effect of viola tricolor on neuroblastoma cells in vitro. Aust J Herb Med, 24: 93-96.
Natelson EA, Giovanella BC, Verschraegen CF, Fehir KM, De Ipolyi PD, Harris N, Stehlin JS. 1996. Phase I clinical and pharmacological studies of 20-(S)-camptothecin and 20-(S)-9-nitrocamptothecin as anticancer agents. Ann N Y Acad Sci, 803: 224-230.
Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C, Holcombe RF. 2009. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res, 1: 25-37.
Noorafshan A, Ashkani-Esfahani S. 2013. A review of therapeutic effects of curcumin. Curr Pharm Des, 19: 2032-2046.
Nussbaumer S, Bonnabry P, Veuthey JL, Sandrine F. 2011. Analysis of anticancer drugs: A review. Talanta, 85: 2265-2289.
Patel KR, Brown A, Jones DJL, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K. 2010. Clinical pharmacology of Resveratrol and its metabolites in colorectal cancer patients. Cancer Res, 70: 7392-7399.
Perez AT, Arun B, Tripathy D, Tagliaferri MA, Shaw HS, Kimmick GG, Cohen I, Shtivelman E, Caygill KA, Grady D, Schactman M, Shapiro CL. 2010. A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat, 120: 111-118.
Piao BK, Wang X, Xie GR, Mansmann U, Mattes H, Beuth J, Lin HS. 2004. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Res, 24: 303-310.
Sadeghnia HR, Ghorbani Hesari T, Mortazavian SM, Mousavi SH, Tayarani-Najaran Z, Ghorbani A. 2014. Viola tricolor induces apoptosis in cancer cells and exhibits antiangiogenic activity on chicken chorioallantoic membrane. BioMed Res Int, 2014: 625792.
Saklani A, Kutty SK. 2008. Plant-derived compounds in clinical trials. Drug Discov Today, 13: 161-171.
Samoszuk M, Tan J, Chorn G. 2005.The chalcone butein from Rhus verniciflua stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. BMC Complement Alter Med, 5: 5.
Schink M, Tröger W, Dabidian A, Goyert A, Scheuerecker H, Meyer J, Fischer IU, Glaser F. 2007. Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients. A randomized phase III trial. Forsch Komplementärmed, 17: 9-17.
Scho¨ffski P, Riggert S, Fumoleau P, Campone M, Bolte O, Marreaud S, Lacombe D, Baron B, Herold M, Zwierzina H, Wilhelm-Ogunbiyi K, Lentzen H, Twelves C. 2004. Phase I trial of intravenous aviscumine (rViscumin) in patients with solid tumors: a study of the European organization for research and treatment of cancer new drug development group. Ann Oncol, 15: 1816-1824.
Semiglasov VF, Stepula VV, Dudov A, Lehmacher W, Mengs U. 2004. The standardised mistletoe extract PS76A2 improves QoL in patients with breast cancer receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res, 24: 1293-1302.
Shanafelt TD, Lee YK, Call TG, Nowakowski GS, Dingli D, Zent CS, Kay NE. 2006. Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies. Leuk Res, 30: 707-712.
Sharma H, Parihar L, Parihar P. 2011. Review on cancer and anticancerous properties of some medicinal plants. J Med Plants Res, 5: 1818-1835.
Sharma RA, Ireson CR, Verschoyle RD, Hill KA, Williams ML, Leuratti, Manson MM, Marnett LJ, Steward WP, Gescher A. 2001. Effects of dietary curcumin on glutation S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relation with drug levels. Clin Cancer Res, 7: 1452-1458.
Shimada Y, Yoshino M, Wakui A, Nakao I, Futatsuki K, Sakata Y, Kambe M, Taguchi T, Ogawa N.1993. Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 gastrointestinal cancer study group. J Clin Oncol, 11: 909-913.
Shu L, Cheung KL, Khor TO, Chen C, Kong AN. 2010. Phytochemicals: cancer chemo-prevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev, 29: 483- 502.
Smoliga JM, Baur JA, Hausenblas H. 2011. Resveratrol and health – a comprehensive review of human clinical trials. Mol Nutr Food Res, 55: 1129-1141.
Son YO, Lee KY, Lee JC. 2005. Selective antiproliferative and apoptotic e ff ects of flavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines. Toxicol Lett, 155: 115-125.
Stevenson JP, Rosen M, Sun W, Gallagher M, Haller DG, Vaughn D, Giantonio B, Zimmer R, Petros WP, Stratford M, Chaplin D, Young SL, Schnall M, O'Dwyer PJ. 2003. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol, 21: 4428-38.
Su CK, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J, Koong A, Goffinet D, Le QT. 2004. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Int J Radiat Oncol Biol Phys, 60: 171-7.
Suh SO, Kroh M, Kim NR, Joh YG, Cho MY. 2002. Effects of red ginseng upon postoperative immunity and survival in patients with stage III gastric cancer. Am J Chin Med, 30: 483-494.
Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, Gong J, Zhong Z, Xu Z, Dang Y, Guo J, Chen X, Wang Y. 2011. Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine, 6: 27.
Tanaka Sh, Haruma K, Yoshihara M, Kajiyama G, Kira K, Amagase H, Chayama K. 2006. Aged Garlic Extract Has Potential Suppressive Effect on Colorectal Adenomas in Humans. J Nutr, 136: 821S-826S.
Tavakkol-Afshari J, Hajzadeh MR, Ghorbani A, Parsaie H. 2006. Ethanolic extract of Allium sativum has antiproliferative effect on Hep2 and L929 cell lines. Pharmacogn Mag, 2: 29-31.
Teiten M, Gaascht F, Dicato M, Diederich M. 2013. Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions. Biochem Pharmacol, 89: 1239-1247.
Townsend DM, Tew KD. 2003. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene, 22: 7369–7375.
Verschraegen CF, Gilbert BE, Loyer E, A Huaringa, G Walsh, RA Newman, V Knight. 2004. Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced pulmonary malignancies. Clin Cancer Res, 10: 2319-2326.
WHO, 2014. Cancer. Fact Sheet No. 2971, World health organization, geneva, switzerland. http://www.who.int.
Wilken R, Veena MS, Wang MB, Srivatsan ES. 2011. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer, 10: 12.
Yun TK, Choi SY. 1990. A case-control study of ginseng intake and cancer. Int J Epidemiol, 19: 871-876.
Yun TK, Choi SY. 1995. Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 Pairs1. Cancer Epidemiol Biomarkers Prev, 4: 401-408.
Zhuang SR, Chen SL, Tsai JH, Huang CC, Wu TC, Liu WS, Tseng HC, Lee HS, Huang MC, Shane GT, Yang CH, Shen YC, Yan YY, Wang CK. 2009. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother Res, 23: 785-790.
Zwierzina H, Bergmann L, Fiebig H, Aamdal S, Schoffski P, Witthohn K, Lentzen H. 2011. The preclinical and clinical activity of aviscumine: A potential anticancer drug. Eur J cancer, 47: 1450-1457. | |||
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