Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 2، دوره 17، شماره 12، اسفند 2014، صفحه 929-938 اصل مقاله (1.53 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2015.3849 | ||
| نویسندگان | ||
| Fatemeh Forouzanfar1؛ Bibi Sedigheh Fazly Bazzaz2؛ Hossein Hosseinzadeh* 3 | ||
| 1Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Nigella sativa seeds have wide therapeutic effects and have been reported to have significant effects against many ailments such as skin diseases, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza and eczema. Thymoquinone (TQ) is one of the most active constituent and has different beneficial properties. Focus on antimicrobial effects, different extracts of N. sativa as well as TQ, have a broad antimicrobial spectrum including Gram-negative, Gram-positive bacteria, viruses, parasites, schistosoma and fungi. The effectiveness of N. sativa seeds and TQ is variable and depends on species of target microorganisms. The present review paper tries to describe all antimicrobial activities that have been carried out by various researchers. | ||
| کلیدواژهها | ||
| Nigella Sativa؛ Thymoquinone Antibacterial؛ Antifungal؛ Antimicrobial؛ Antiparasite؛ Antischistosoma؛ Antivirus | ||
| مراجع | ||
|
1. Goreja WG. Black seed: nature’s miracle remedy. New York, NY: Amazing Herbs Press; 2003.
2. Khan MR. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammo-pharmacology 1999; 7:13-35.
3. Tembhurne SV, Feroz S, Sakarkar DM. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res 2014; 8:166-167.
4. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed 2013; 3:337-352.
5. Staphylakis PK, Gegiou D. The sterols of Nigella sativa seed oil. Phytochemistry 1986; 25:761-763.
6. Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab AN, et al. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol Pharm Bull 2001; 24:307-310.
7. Haq A, Lobo I, Al-Tufail M, Rama NR, Sedairy ST. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol 1999; 21:283-285.
8. Parvardeh S, Nassiri-Asl M, Mansouri MT, Hosseinzadeh H. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. J Med Plants 2005; 4:45-52.
9. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine 2004; 11:56-64.
10. Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, Mansouri MT. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit 2005; 11:BR106-BR110.
11. Hosseinzadeh H, Taiari S, Nassiri-Asl M. Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle. N-S Arch Pharmacol 2012; 385:503-508.
12. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol 2006; 6:1135-1142.
13. Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El-Hajj Z, Diestel A, et al. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med 2008; 12:330-342.
14. Halawani E. Antibacterial activity of thymo-quinone and thymohydroquinone of Nigella sativa L. and their interaction with some antibiotics. Adv Biol Res 2009; 3:148-152.
15. Abdel Azeiz AZ, Saad AH, Darweesh MF. Efficacy of thymoquinone against vaginal candidiasis in prednisolone-induced immunosuppressed mice. J Am Sci 2013; 9:155-159.
16. Phillips JD. Medicinal plants. Biologist 1992; 39, 187–191.
17. Sayed MD. Traditional medicine in health care, J. Ethnopharmacol 1980; 2:19-22.
18. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res 2000; 14:323-328.
19. Rajsekhar S, Kuldeep B. Pharmacognosy and pharmacology of Nigella sativa. J Pharm Res 2011; 2:36-39.
20. Merfort I, Wray V, Barakat HH, Hussein SAM, Nawwar MAM, Willuhn G. Flavonoid triglycerides from seeds of Nigella sativa. Phytochemistry 1997; 46, 359-363.
21. Aboutabl EA, El-Azzouny AA, Hammerschmidt FJ. Aroma volatiles of Nigella sativa L. seeds. Progress in Essential Oil Research. Walter de Gruyter and Co, Berlin, New York 1986; 49-55.
22. Warrier PK, Nambiar VPK, Ramankutty C, Vasudevan Nair R. Indian Medicinal Plants: A Compendium of 500 Species. Telangana: Orient Longman; 2004: 139-142.
23. The Ayurvedic Pharmacopoeia of India, part 1, Ministry of Health and Family Welfare. New Delhi. 1989; 119-120.
24. Hosseinzadeh H, Moghim FF, Mansouri SMT. Effect of Nigella sativa seed extracts on ischemia-reperfusion in rat skeletal muscle. Pharmacologyonline 2007; 2:326-335.
25. Hosseinzadeh H, Eskandari M, Ziaee T. Anti-tussive effect of thymoquinone a constituent of Nigella Sativa Seeds in guinea pigs. Pharmacology online 2008; 2:480-484.
26. El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective effect of black seed. J Ethnopharmacol 2003; 84: 251–258.
27. Bin Sayeed MS, Shams T, Fahim Hossain S, Rahman MR, Mostofa A, Fahim Kadir M, et al. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol 2014; 152:156-162.
28. Rajkapoor B, Anandan R, Jayakar B. Anti-ulcer effect of Nigella sativa Linn against gastric ulcers in rats. Curr Sci 2002; 82:177-179.
29. Boskabady MH, Mohsenpoor N, Takaloo L. Anti asthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine 2010; 17:707–713.
30. Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, David KY. Anti cancer activity of Nigella sativa. Cancer Cell Int 2009; 9: 29.
31. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005; 5:1749–1770.
32. Majdalawieh AF, Hmaidan R, Carr RI. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol 2010; 131:268–275.
33. Khan MR. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology 1999; 7:13-35.
34. Bukhari MH, Khalil J, Qamar S, Qamar Z, Zahid M, Ansari N, et al. Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats. J Coll Physicians Surg Pak 2011; 21:151-156.
35. Salim EI. Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay. Oncol Lett 2010; 1:913-924.
36. Kolahdooz M, Nasri S, Modarres SZ, Kianbakht S, Huseini HF. Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial. Phytomedicine 2014; 21:901-905.
37. Sultan MT, Butt MS, Anjum FM, Jamil A. Influence of black cumin fixed and essential oil supplementation on markers of myocardial necrosis in normal and diabetic rats. Pak J Nutr 2009; 8:1450-1455.
38. Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR, Soukhtanloo M. Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chin J Integr Med 2014; 1-7.
39. Hosseinzadeh H, Tafaghodi M, Mosavi MJ, Taghiabadi E. Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats. J Acupunct Meridian Stud 2013; 6:18-23.
40. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 2007; 14: 621-627.
41. Hosseinzadeh H, Fazly Bazzaz BS, Motevaly Haghi M. Antibacterial activity of total extracts and essential oil of Nigella sativa L. seeds in mice, Pharmacol online 2007; 2: 429-435.
42. Aljabre SH, Randhawa MA, Akhtar N, Alakloby OM, Alqurashi AM, Aldossary A. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. J Ethnopharm 2005; 101:116-119.
43. Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol 2000; 22:729-740.
44. Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000; 88:308-316.
45. Morsi NM. Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol Pol 2000; 49:63-74.
46. Hannan A, Saleem S, Chaudhary S, Barkaat M, Arshad MU. Anti-bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. J Ayub Med Coll Abbottabad 2008; 20:72-74.
47. Bakathir HA, Abbas NA. Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Compl Altern Med 2011; 8:159-164.
48. Monika T, Sasikala P, Vijaya Bhaskara Reddy M. A investigational of antibacterial activities of Nigella sativa on mastaitis in dairy crossbred cows. Int J Adv Technical Res 2013; 3:263-272.
49. Hanafy MS, Hatem ME. Studies on the antimicrobial activity of Nigella sativa seed (black cumin). J Ethnopharmacol 1991; 34:275–278.
50. Nair MKM, Vasudevan P, Venkitanarayanan K. Antibacterial effect of black seed oil on Listeria monocytogenes. Food Cont 2005; 16:395–398.
51. Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation. BMC Complement Altern Med 2011; 11:1-6.
52. Harzallah HJ, Kouidhi B, Flamini G, Bakhrouf A, Mahjoub T. Chemical composition, antimicrobial potential against cariogenic bacteria and cytotoxic activity of Tunisian Nigella sativa essential oil and thymoquinone. Food Chem 2011; 129:1469–1474.
53. Hasan NA, Nawahwi MZ, Malek, HA. Anti microbial activity of Nigella sativa seed extract. Sains Malaysiana 2013; 42: 143-147.
54. Deepak SS, Sikender M, Garg V, Samim M. Entrapment of seed extract of Nigella sativa into thermosensitive (NIPAAm–Co–VP) co-polymeric micelles and its antibacterial activity. Int J Pharm Sci Drug Res 2011; 3:246-252.
55. Evirgen O, Gokçe A, Ozturk OH, Nacar E, Onlen Y, Ozer B, et al. Effect of thymoquinone on oxidative stress in Escherichia coli-Induced Pyelonephritis in Rats. Curr Ther Res Clin Exp 2011; 72:204-215.
56. Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, et al. Novel antifungal defensins from Nigella sativa L. seeds. Plant Physiol Biochem 2011; 49:131-137.
57. El-Nagerabia SA, Al-Bahryb SN, Elshafieb AE, AlHilalib S. Effect of Hibiscus sabdariffa extract and Nigella sativa oil on the growth and aflatoxin B1 production of Aspergillus flavus and Aspergillus parasiticus strains. Food Cont 2012; 25:59-63.
58. Sunita M, Meenakshi SH. Chemical composition and antidermatophytic activity of Nigella sativa essential oil. Afr J Pharm Pharacol 2013; 7:1286-1292.
59. Fierro IM, Barja-Fidalgo C, Cunha FQ, Ferreira SH. The involvement of nitric oxide in the anti-Candida albicans activity of rat neutrophils. Immunology 1996; 89:295-300.
60. Khan MA, Ashfaq MK, Zuberi HS, Mahmood MS, Gilani AH. The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytother Res 2003; 17:183-186.
61. Bita A , Rosu AF, Calina D, Rosu L, Zlatian O, Dindere C, et al. An alternative treatment for Candida infections with Nigella sativa extracts Eur J Hosp Pharm 2012; 19:162.
62. Mahmoud MR, El-Abhar HS, Saleh S. The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. J Ethnopharmacol 2002; 79:1-11.
63. Aboul-Ela EI. Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Mutat Res 2002; 516: 11–17.
64. Mohamed AM, Metwally NM, Mahmoud SS. Sativa seeds against Schistosoma mansoni different stages. Mem Inst Oswaldo Cruz 2005; 100: 05-211.
65. Shenawy El, Nahla S, Soliman MF, Reyad SI. The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti- schistosomiasis agents in mice. Rev Inst Med Trop Sao Paulo 2008; 50:29-36.
66. Peterhans E. Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. J Nutr 1997; 127:962S– 965S.
67. Salem ML, Hossain MS. In vivo acute depletion of CD8 (+) T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. Int J Immunopharmacol 2000; 22:707–718.
68. Barakat EM, El Wakeel LM, Hagag RS. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol 2013; 19:2529-2536.
69. Akhtar MS, Riffat S. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children J Pak Med Assoc 1991; 41:185-187.
70. Okeola VO, Adaramoye OA, Nneji CM, Falade CO, Farombi EO, Ademowo OG. Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis. Parasitol Res 2011; 108:1507-1512.
71. Baghdadi HB, Al-Mathal EM. Anti-coccidial activity of Nigella sativa L. J Food Agricul Envir 2011; 9: 10–17. | ||
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