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Farahani, Farhad, karimi Yazdi, Alireza, Ghasemi, Mohammad, Shariatpanahi, Elnaz, kajbafzadeh, Abdol-Mohammad, Amanpour, Saeid. (1393). Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model. , 27(2), 95-100. doi: 10.22038/ijorl.2015.3580
Farhad Farahani; Alireza karimi Yazdi; Mohammad Ghasemi; Elnaz Shariatpanahi; Abdol-Mohammad kajbafzadeh; Saeid Amanpour. "Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model". , 27, 2, 1393, 95-100. doi: 10.22038/ijorl.2015.3580
Farahani, Farhad, karimi Yazdi, Alireza, Ghasemi, Mohammad, Shariatpanahi, Elnaz, kajbafzadeh, Abdol-Mohammad, Amanpour, Saeid. (1393). 'Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model', , 27(2), pp. 95-100. doi: 10.22038/ijorl.2015.3580
Farahani, Farhad, karimi Yazdi, Alireza, Ghasemi, Mohammad, Shariatpanahi, Elnaz, kajbafzadeh, Abdol-Mohammad, Amanpour, Saeid. Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model. , 1393; 27(2): 95-100. doi: 10.22038/ijorl.2015.3580

Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model

Iranian Journal of Otorhinolaryngology
مقاله 3، دوره 27، شماره 2، خرداد 2015، صفحه 95-100    اصل مقاله (224.35 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2015.3580
نویسندگان
Farhad Farahani1؛ Alireza karimi Yazdi1؛ Mohammad Ghasemi2؛ Elnaz Shariatpanahi* 3؛ Abdol-Mohammad kajbafzadeh4؛ Saeid Amanpour5
1Otolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Department of Otolaryngology, School of Medicine, Hamadan University of Medical Sciences & Health Services, Hamadan, Iran.
4Pediatric Urology Research Center, Children’s Hospital Medical Center, Tehran University of Medical Science, Tehran, Iran.
5Cancer Model Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
چکیده
Introduction:
To describe the underlay tympanoplasty technique using an acellular dermal graft(AlloDerm) for tympanic membrane (TM) reconstruction in a guinea pig model and to demonstrate the feasibility of the technique using AlloDerm tissue harvested from the prepuce as a source of tissue for future grafting in human TM reconstruction.
 
Materials and Methods:
The prepuce was divided during circumcision and the acellular dermis was prepared using a number of standard processes. Two groups of guinea pigs were prepared. In the case group (20 guinea pigs and 40 ears) removal of TM was performed with tympanoplasty using AlloDerm, and in the control group (eight guinea pigs and 16 ears), removal of TM was performed without tympanoplasty. In each group, the TM was completely removed in one ear and partially removed on the other side, and the integrity of the TMs was re-evaluated after 8 weeks.
 
Results:
In the case group, the healing rates in the completely and partially removed TMs were 83.3% and 94.4%, respectively. The difference in healing rate (0% and 66.7%, respectively) was statistically significant (P<0.05).
 
Conclusion: 
The use of AlloDerm is safe and effective in the repair of TM perforations in a guinea pig model. Acceptable results of AlloDerm tympanoplasty in a guinea pig model may pave the way for the effective use of this material in human TM reconstructions.
کلیدواژه‌ها
Partial perforation؛ Total perforation؛ Tympanoplasty
مراجع

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