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Keyvani, Vahideh, Kerachian, Mohammad Amin. (1393). The Effect of Fasting On the Important Molecular Mechanisms Related to Cancer Treatment. , 2(3), 113-118. doi: 10.22038/jfh.2014.3510
Vahideh Keyvani; Mohammad Amin Kerachian. "The Effect of Fasting On the Important Molecular Mechanisms Related to Cancer Treatment". , 2, 3, 1393, 113-118. doi: 10.22038/jfh.2014.3510
Keyvani, Vahideh, Kerachian, Mohammad Amin. (1393). 'The Effect of Fasting On the Important Molecular Mechanisms Related to Cancer Treatment', , 2(3), pp. 113-118. doi: 10.22038/jfh.2014.3510
Keyvani, Vahideh, Kerachian, Mohammad Amin. The Effect of Fasting On the Important Molecular Mechanisms Related to Cancer Treatment. , 1393; 2(3): 113-118. doi: 10.22038/jfh.2014.3510

The Effect of Fasting On the Important Molecular Mechanisms Related to Cancer Treatment

Journal of Nutrition,Fasting and Health
مقاله 8، دوره 2، شماره 3، آذر 2014، صفحه 113-118    اصل مقاله (833.9 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/jfh.2014.3510
نویسندگان
Vahideh Keyvani1؛ Mohammad Amin Kerachian* 2
1Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Fasting does have remarkable benefits in the treatment of cancer and another diseases such as metabolic syndrome, diabetes, and a multitude of other chronic diseases. It has been determined that fasting could play an important role during cancer treatment and progression via the regulation of insulin-like growth factor-1 (IGF-1) as well as other growth factors. Also, it has been shown that fasting would enhance the chemotherapy effect in cancer patients, selectively protects normal cells and organisms from chemotherapy toxicity, while simultaneously sensitizing tumors. In this article, we discuss the benefits of fasting in the treatment of cancer through several different molecular pathways.
کلیدواژه‌ها
Cancer Treatment؛ Chemotherapy toxicity؛ Fasting؛ Insulin-like growth factor-1
مراجع
  1. "Cancer Fact sheet N°297". World Health Organization. February 2014. Retrieved 10 June 2014.
  2. "Metastatic Cancer: Questions and Answers". National Cancer Institute. Retrieved 2008-08-28.
  3. Risau, W; Flamme, I (1995). "Vasculogenesis.". Annual review of cell and developmental biology 11: 73–91. doi:10.1146/annurev.cb.11.110195.000445. PMID 8689573.
  4. Fiona Lalloo. Genetics of Oncologists. ISBN.1901346196. remedica Publishing.
  5. De Lorenzo MS, Baljinnyam E, Vatner DE, Abarzúa P, Vatner SF, Rabson AB. Caloric restriction reduces growth of mammary tumors and metastases. Carcinogenesis. 2011 Sep;32(9):1381-7. doi: 10.1093/carcin/bgr107.
  6. Lee C, Raffaghello L, Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat 2012;15:114­22
  7. lee C, Raffaghello L, Brandhorst S,Safdie FM, Bianchi G, Martin-Montalvo A, et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med 2012;4:124ra27.
  8. Raffaghello L, Lee C, Safdie FM , Wei M, Madia F, Bianchi G,  et al. Stravation-dependent differential stress resistance protects normal but not cancer cells against high­dose chemotherapy. Proc Natl Acad Sci USA 2008;105:8215­20
  9. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E et al. (2010). Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res 70: 1564–1572.
  10. Nørrelund H. The metabolic role of growth hormone in humans with particular reference to fasting. Growth Horm IGF Res 2005;15:95­122.
  11. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, et al. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY) 2009;1:988­1007.
  12. Jones RA, Petrik JJ, Moorehead RA. (2010). Preneoplastic changes persist after IGF-IR downregulation and tumor regression. Oncogene 29: 4779–4786.
  13. Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN. Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. Br J Cancer. 2002 May 20;86(10):1615-21
  14. Caso J, Masko EM, Ii JA, Poulton SH, Dewhirst M, Pizzo SV, Freedland SJ. The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model. Prostate. 2012 Oct 4. doi: 10.1002/pros.22586.
  15. Facchetti F, Monzani E, Cavallini G, Bergamini E, La Porta CA. Effect of a caloric restriction regimen on the angiogenic capacity of aorta and on the expression of endothelin-1 during ageing. 2007 Jul;42(7):662-7.
  16. Giovanna Galeati, Monica Forni, Marcella Spinaci, Augusta Zannoni, Nadia Govoni, Luciana A. Ribeiro, Eraldo Seren, Carlo Tamanini Fasting influences steroidogenesis, vascular endothelial growth factor (VEGF) levels and mRNAs expression for VEGF, VEGF receptor type 2 (VEGFR-2), endothelin-1 (ET-1), endothelin receptor type A (ET-A) and endothelin converting enzyme-1 (ECE-1) in newly formed pig corpora lutea. Volume 28, Issue 3, April 2005, Pages 272–284.
  17. Knowles J, Loizidou M, Taylor I. Endothelin-1 and angiogenesis in cancer. 2005 Oct;3(4):309-14.
  18. Ala-Eddin Al Moustafa. Fasting inhibits human cancer progression via the epithelial-mesenchymal transition process: Important evidence unraveled(Link) Clin Cancer Investig J 2012;1:181-3.
  19. Junta Ito, Hiroyuki Uchida , Takayuki Yokote , Kazuo Ohtake , Jun Kobayashi. Fasting-induced intestinal apoptosis is mediated by inducible nitric oxide synthase and interferon-γ in rat. Gastrointestinal and Liver PhysiologyPublished 1 June 2010Vol. 298no. 6, G916-G926DOI: 10.1152/ajpgi.00429.2009.
  20. Yong Liu, Yizhou He, Aiwen Jin, Andrey P. Tikunov, Lishi Zhou, Laura A. Tollini,Patrick Leslie, Tae-Hyung Kim, Lei O. Li, Rosalind A. Coleman, Zhennan Gu, Yong Q. Chen, Jeffrey M. Macdonald, Lee M. Graves, Yanping Zhang. Ribosomal protein–Mdm2–p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. vol. 111 no. 23, Yong Liu,  E2414–E2422, doi: 10.1073/pnas.1315605111
  21. Would fasting during chemotherapy improve treatment effectiveness? [Food for breast cancer web site]. Available at: http://foodforbreastcancer. com/ articles/ would- fasting- during- chemotherapy- improve- treatment- effectiveness%3f
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