Renoprotective effect of hydroalcoholic extract of Rheum ribes root in diabetic female rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 4، دوره 4، شماره 6، بهمن و اسفند 2014، صفحه 392-401 اصل مقاله (975.17 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2014.3371 | ||
| نویسندگان | ||
| Shokri Hamzeh1؛ Farah Farokhi* 1؛ Reza Heydari1؛ Ramin Manaffar2 | ||
| 1Department of Biology, Faculty of Basic Science, Urmia University, Urmia, I. R. Iran | ||
| 2Artemia and Aquatic Animals Research Institute of Urmia University, Urmia, I. R. Iran | ||
| چکیده | ||
| Objective: Medical plants, as rich sources of natural antioxidants with antidiabetic effects, are used worldwide to diminish a variety of symptoms and many diseases. R. ribes L., which belongs to the family of polygonaceae, can provide symptomatic relief and assist in the prevention of the secondary complications of the diabetes. Material and Methods: 36 female adult rats were randomly divided into 6 groups of 6. Normal Control groups treated with normal saline. Positive control groups treated with hydroalcohlic extract of R. ribes root (150 mg/kg) daily by gavages for 4 consecutive weeks. Diabetes was inducedby injection of 120 mg/kg alloxan monohydrate intraperitoneally. Two diabetic groups were treated with different doses of R. ribes root extract. The sixth diabetic groups were treated with glibenclamide (0.6 mg/kg). At the end of 28 days, blood samples were collected and their kidney tissues were processed for light microscopy. Results: The results showed that hydro-alcoholic extract of R. ribes decreased the level of glucose, cholesterol, triglyceride, urea and creatinine in diabetic rats (p<0.05) in compared with diabetic rats, while the level of HDL increased at the same group (p<0.05). Histopathological changes of kidney samples were comparable with respective control. In diabetic rats, kidney sections showed atrophy of glomerular capillaries with increased Bowman's space and acute tubular necrosis. The groups that were treated with R. ribes root were improved towards normal condition. Conclusion: It is interesting to note that hydroalcohlic extract of R. ribes root improves renal dysfunction in alloxan-induced diabetic rats through controlling blood glucose and renal protective effects. | ||
| کلیدواژهها | ||
| Alloxan؛ Diabetes Mellitus؛ R. ribes root extract | ||
| مراجع | ||
|
Abe I, Seki T, Noguchi H. 2000. Galloyl esters from rhubarb are potent inhibitors of squaleneopoxidase, a key in cholesterol biosynthesis. Planta Med, 66: 753-756.
Abou-Seif MA, Yussef AA. 2004. Evaluation of some biochemical changes in diabetic patients. Clin Chem Acta, 346: 161-170.
Almdal TP,Vilstrup H. 1988. Strict insulin treatment normalizes the organic nitrogen contents and the capacity of urea-N synthesis in experimental diabetes in rats. Diabetologica, 31: 114-118.
BaytopT. 1999. Therapy with Medicinal Plants in Turkey (2nd edn). Nobel Tıp Kitabevleri: Istanbul, 319-320.
Broadhurst CL.1997. Nutrition and non-insulin dependent diabetes from ananthropologicalperspective. Alt MedRev, 2: 378–399.
Budavari S.1989. The mesk index an encyclopedia of chemicals. Drug sbiological. 11th Ed , P.1431, Merck and Co.INC. Rahwa. USA.
Byung-Hyun Park, Jin-Woo Park. 2001. The protective effect of Amomumxanthides extracts against alloxan-induced diabetic rats through the suppression of NF Bactivation. Exp Med, 33: 64-68.
DCCT. 2002. Writing Team for the Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complication Research Group, Effect of Intensive Therapy on the Microvascular Complications of type 1 Diabetes mellitus”, JAMA, 287: 2563-2569.
Dhandapani S, Subramanian V, Rajagopal S, Namasivayam N. 2002. Hypolipidemic effect of CuminumcyminumL .onalloxan– induced diabetic rats. Phar Res, 46: 251-255.
Eddouks M, Maghrani M . 2004. Phlorizin-like effect of Fraxinusexcelsiorin normal and diabetic rats. J Ethnopharmacol, 9: 149-154.
Fairbairn JW. 1977. Anthraquin one laxatives, John Wiley & sons, Inc. New York.
Fukuda T, Ito H, Yoshida T. 2004. Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice. Biofactors, 21: 251-253.
FalahHosseini H, Heshmat R, Mohseni F, Jamshidi Ah, Alavi SHR, Ahvazi M, Ardeshir Larijani MB 2008. The Efficacy Of Rheum Ribes L. Stalk Extract On Lipid Profile In Hypercholesterolemic Type II Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. J Med Plants, 7: 92-97.
Ghorbani A. 2013. Best herbs for managing diabetes: A review of clinical studies. Braz J Pharm Sci, 49: 413-422. Goel V, Ooraikol B, Basu TK. 1997. Cholesterol lowering effects of Rhubarb stack fiber in hypercholesterolemic men. Journal of American College of Nutrition Dec, 16: 600-604.
Hadjzadeh MA, Parsaee H, Sadeghian A. 2004. Cholesterol lowering effect of Rheum ribes in hypercholesterolemic rabbits. Med J Islam Repub Iran, 18: 277–280.
Halder N, Joshi S, Gupta SK. 2003. Lens aldose reductase inhibiting potential of some indigenous plants. J Ethnopharmacol, 86: 113-6.
Huang YH, Shi M, Zheng WD, Zhang LJ, Chen ZX, Wang XZ. 2006. Therapeutic effect of interleukin -10 on CC14-induced hepatic fibrosis in rats. World J Gastroenterol, 12: 1386-1391.
Jothivel N, Ponnusamy SP, Appachi M, Singaravel S, Rasilingam D, Deivasigamani K, Thangavel S. 2007. Anti-diabetic activity of methanol leaf extract of Costuspictus D. DON in alloxan-induced diabetic rats. Health Sci, 53: 655-663.
Kazemi S, Asgary S, Moshtaghian J, Rafieian M, Adelnia A. 2010. Liver-protective Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy. Diabetes Res Clin Pract, 13: 46-53.
Krishnaiah DR, Sabatly R, Nithyanandam R. 2010. A review of the antioxidant potential of medicinal plant species.J Food Bioproducts Processing, 89: 217-233.
Li CL, Ye YW.1981. Effect of rhapontin of Rheum hotaoense on lipidand lipoprotein level serum. Acta Pharm Sinica, 17: 699-702.
Yang JW, Li LS. 1993. Effect of Rheum on renal hypertrophy and hyper filtration of experimental diabetes in rat. Zhongguo Zhong Xi Yi Jie He Za Zhi, 13: 286-288.
Li Leishi.1996. End Stage renal disease in China; Kidney International, 49: 287-301.
Li LS, Liu ZH. 1991.Clinical and experimental studies of rheum on preventing progression of chronic renal failure. Zhong Xi Yi Jie He Za Zhi, 11: 392-396, 387.
Liu CT, Sheen LY, Lii CK. 2007. Does garlic have a role as an antidiabetic agent? Mol. Nutr. Food Res, 51: 1353–1364.
Lokesh D, Amit SD. 2006. Diabetes mellitus- its possible pharmacological evaluation technique sand naturotherapy. Int J Green Pharm, 1:15-28.
Machlean W,Townsend P. 2001. Rhubarb (Dahung). Rheum palmatum.
Malviya N, Jain S, Malviya S .2010 . Antidiabetic Potential of Medicinal Plants, Acta Pol Pharm, 67: 113-118.
Marles RJ, Farnsworth N. 1996. Antidiabetic Plants and their Active Constituents: An update. Prot J Bot Med, 1: 85-135.
Matsuda H, Morikawa T, Toguchida I, Park J Y, Harima S, Yoshikawa M. 2001. Antioxidant constituents from rhubarb: Structural requirements of stilbenes for the activity and structures of two new anthraquinoneglucosides. Bioorg Med Chem, 9:41–50.
Ozbek H, Ceylan E, Kara M, Ozgokce F, Koyuncu M. 2004. Hypoglycemic effect of Rheum ribesroots in alloxan induced diabetic and normal mice. Scand J Lab Anim Sci, 31: 113–115.
Peng A, Gu Y, Lin SY. 2005. Herbal treatment for renal diseases. Ann Acad Med Singapore, 34: 44-51.
Ranjan C, Ramanujam R. 2002. Diabetes and insulin resistance associateddisorders: Disease and the therapy. Curr Sci, 83:1533.
Reimer RA, Russell JC. 2008. Glucose tolerance, lipids and GLP-1secretion in JCR: LA-cp rats fed a high protein fiber diet. Obesity, 16: 40-6.
Shaw JE, Sicree RA, Zimmet PZ. 2010. Global Estimates of the Prevalence of Diabetes for 2010 and 2030, Diabetes Res Clin Pract, 87: 4-14.
Sim Sk. 1967. Medplant glycoside, University of Torento, Press Toronto.
Szkudelski T. 2001. The mechanism of Alloxan and Streptozotocin action in B cells of the rat pancreas. Physiol Res, 50: 536-546.
Tuzlacı E, Meriçli AH .1991. Some studies on Isgın (Rheum ribes) and its distribution in Turkey. Proceeding of the 9th Symposium on Plant Drugs (16- 19 May 1991, Eskisehir), Turkey, 336-341.
Tyler VE, Brady LR, Robbers JE. 1988. Pharmacognosy, 9th ed. P. 6, Philadelphia, Lea & Febiger
Vaoler S, Hassen KF, Aogenaes Q. 1981. Effects of different kinds of fiber on post prandial blood glucose in insulin dependent diabetes mellitus. Acta Med Scanda, 208: 389-391 .
Vaya J, Aviram M. 2002. Nutritional antioxidants: mechanism of action, analyses of activities and medical applications. Curr Med Chem Immunol Endocr Metab Agents, 1: 99-117.
Winocour PH, Durrington PN, Bhatnagar D, Ishola M, Arrol S, Mackness M. 1992. Abnormalities of VLDL, IDL and LDL characterize insulin dependent diabetes mellitus. Arteroscler Thromb, 12: 920-928.
Yarnell E .2002. Botanical medicines for the urinary tract. World J Urol, 20:285-293.
Yokozawa T, Fujioka K, Oura H, Nonaka G, Nishioka I. 1991. Effects of rhubarb tannins on uremic toxins. Nephron, 58: 155–160. | ||
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