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Lai, YF, Ng, HJ. (1393). Fasting and Warfarin. , 2(3), 104-105. doi: 10.22038/jfh.2014.3311
YF Lai; HJ Ng. "Fasting and Warfarin". , 2, 3, 1393, 104-105. doi: 10.22038/jfh.2014.3311
Lai, YF, Ng, HJ. (1393). 'Fasting and Warfarin', , 2(3), pp. 104-105. doi: 10.22038/jfh.2014.3311
Lai, YF, Ng, HJ. Fasting and Warfarin. , 1393; 2(3): 104-105. doi: 10.22038/jfh.2014.3311

Fasting and Warfarin

Journal of Nutrition,Fasting and Health
مقاله 2، دوره 2، شماره 3، آذر 2014، صفحه 104-105    اصل مقاله (208.55 K)
نوع مقاله: Letter to the Editor
شناسه دیجیتال (DOI): 10.22038/jfh.2014.3311
نویسندگان
YF Lai* 1؛ HJ Ng2
1Department of Pharmacy, Singapore General Hospital, Singapore
2Department of Haematology, Singapore General Hospital, Singapore
چکیده
Recently, we reported the findings of a study on the effects of Ramadan fasting on a group of 32 Muslim patients taking warfarin.13 Weekly INR (international normalized ratio) readings were taken from subjects with previously stable INRs over a three-month period spanning pre-Ramadan to post-Ramadan. We found a statistically significant increase in the mean INR by 0.23 (p=0.006) during Ramadan from the pre-Ramadan month and decreased by 0.28 (p<0.001) after Ramadan. There was no significant difference (p=1.000) in mean INR between the non-Ramadan months. Importantly, there was a decline in the time within therapeutic range (TTR) during Ramadan with a corresponding increase in TTR above the therapeutic target range. %TTR declined from 80.99% before Ramadan to 69.56% during Ramadan (p=0.453). The first out-of-range INR was seen around 12.1 days (95% CI 9.0-15.1) after the start of fasting and returned within range about 10.8 days (95% CI 7.9-13.7) after Ramadan. Time above range increased from 10.80% pre-Ramadan to 29.87% during Ramadan (p=0.027), while time below range increased from 0.57% during Ramadan to 15.49% post-Ramadan (p=0.006). This observation is directly attributable to the effects of fasting.
کلیدواژه‌ها
Fasting؛ Ramadan؛ Warfarin
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