Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 3، دوره 2، شماره 2، خرداد 2012، صفحه 72-78 اصل مقاله (183.13 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2012.33 | ||
| نویسندگان | ||
| Ghulam Moinuddin* ؛ Kshama Devi؛ Deepak Kumar Khajuria | ||
| Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-560027. India | ||
| چکیده | ||
| Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS. | ||
| کلیدواژهها | ||
| Antidepressant activity؛ Imipramine؛ Myristica fragrans | ||
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