Lipid-lowering activity of Cow urine ark in guinea pigs fed with a high cholesterol diet | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 7، دوره 4، شماره 5، آذر و دی 2014، صفحه 354-363 اصل مقاله (537.28 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2014.3036 | ||
| نویسندگان | ||
| Hiren Manubhai Chawda1؛ Divyesh Rasiklal Mandavia1؛ Seema Natvarlal Baxi2؛ Vishalkumar Kishorbhai Vadgama1؛ Chandrabhanu Rajkishor Tripathi* 1 | ||
| 1Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India | ||
| 2Department of Pathology, Government Medical College, Bhavnagar-364001, Gujarat, India | ||
| چکیده | ||
| Objectives: Cow urine ark (CUA), known as “Amrita” as mentioned in Ayurveda, contains anti-hyperglycemic and antioxidant effects. Therefore, we designed the present study to evaluate the lipid lowering activity of CUA and its possible implication in metabolic syndrome. Materials and Methods: Thirty guinea pigs of either sex were divided into five groups: Group 1 and 2 serving as a vehicle and sham control, received normal and high fat diet for 60 days respectively; Group 3, 4 and 5 received high fat diet for 60 days with CUA 0.8 ml/kg, 1.6 ml/kg and rosuvastatin (1.5 mg/kg) on thelast 30 days of study period, respectively. Serum lipid profile (total cholesterol, triglycerides, LDL-C, VLDL-C, HDL-C, total Cholesterol/HDL-C) and serum enzymes (ALT, AST, ALP, LDH and CK-MB) were performed in each group at the beginning and end of the study. Histological study of liver and kidney was done in each group. Results: CUA (0.8 ml/kg) significantly decreased the serum triglycerides and VLDL-C, but CUA (1.6 ml/kg) decreased the total serum Cholesterol, triglycerides and VLDL-C (p < 0.05). Higher dose (1.6 ml/kg) of CUA also increased HDL-C level, significantly (p < 0.05). CUA reduced serum AST, ALP and LDH level, which was statistically significant as well, while it also decreased the accumulation of lipid in hepatocytes as compared to sham control. Conclusions: CUA reduced triglycerides, increased HDL-C and found to be hepatoprotective in animals that are on a high fat diet. | ||
| کلیدواژهها | ||
| Antioxidant activity؛ Cow urine ark؛ Dyslipidemia؛ Hypolipidemia؛ Guinea pig؛ Statin | ||
| مراجع | ||
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