Kisno Saputri, Romadhiyana Kisno Saputri, Setiawan, Bambang, Nugrahenny, Dian, Kania, Nia, Sri Wahyuni, Endang, Widodo, M Aris. (1393). The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats. , 17(7), 541-545. doi: 10.22038/ijbms.2014.3035
Romadhiyana Kisno Saputri Kisno Saputri; Bambang Setiawan; Dian Nugrahenny; Nia Kania; Endang Sri Wahyuni; M Aris Widodo. "The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats". , 17, 7, 1393, 541-545. doi: 10.22038/ijbms.2014.3035
Kisno Saputri, Romadhiyana Kisno Saputri, Setiawan, Bambang, Nugrahenny, Dian, Kania, Nia, Sri Wahyuni, Endang, Widodo, M Aris. (1393). 'The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats', , 17(7), pp. 541-545. doi: 10.22038/ijbms.2014.3035
Kisno Saputri, Romadhiyana Kisno Saputri, Setiawan, Bambang, Nugrahenny, Dian, Kania, Nia, Sri Wahyuni, Endang, Widodo, M Aris. The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats. , 1393; 17(7): 541-545. doi: 10.22038/ijbms.2014.3035
The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats
1Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
2Department of Medical Chemistry and Biochemistry, Research Center for Toxicology, Cancer and Degenerative Disease, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
3Laboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
4Department of Pathology, Research Center for Toxicology, Cancer and Degenerative Disease, Ulin General Hospital, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
5Laboratory of Physiology; Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
چکیده
Objective(s):To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats. Materials and Methods: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m3 (CD25) an hour daily for 6 months with or without supplementation of ethanolic extract of E. cottonii at doses of 150 (EC150) or 300 mg/kg BW (EC300). The number of macrophages was determined using a light microscope. MDA levels were measured by TBARS assay. Results: EC150 insignificantly (P > 0.05) reduces the AM in CD groups compared to non treatment groups. EC150 and EC300 significantly (P < 0.05) decreased MDA levels in CD12.5 and CD25 groups relative to non treatment groups. Conclusion:E. cottonii attenuated oxidative stress in chronic exposure of PM10 coal dust.
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