p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 5، دوره 17، شماره 7، مهر 2014، صفحه 497-501 اصل مقاله (1.65 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2014.3028 | ||
| نویسندگان | ||
| Mahmoud Reza Kalantari1؛ Kazem Anvari2؛ Hasan Jabbari3؛ Fatemeh Varshoee Tabrizi* 2 | ||
| 1Kidney Transplantation Complications Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Solid Tumor Treatment Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Objective(s): Prostate cancer is the world’s leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. Materials and Methods:We studied 98 prostate biopsy blocks (40 adenocarcinoma and 58 benign lesions) for basal cell marker expression. Results: p63 and 34βE12 were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. Conclusion: Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. | ||
| کلیدواژهها | ||
| Basal cell markers؛ Cancer mimickers؛ Prostate adenocarcinoma | ||
| مراجع | ||
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