AD. Diabetes and nutrition: the mitochondrial part. J

Nutr 2001; 131:344– 353.

2. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: A review. J Biochemical Mol Toxicol 2003; 17:24- 38.

3. Emilien G, Maloteaux JM , Ponchon M. Pharmacological management of diabetes: recent progress and future perspective of daily drug treatment. Pharmacol Ther 1999; 81: 37-51.

4. Engelgau MM, Geiss LS. The burden of diabetes mellitus. In: Leahy JL, Clark NG, Cefalu WT. editors. Medical Management of Diabetes Mellitus. Mark Dekker, New York: 2000.p.1–17.

5. Biessels GJ, Smale S, Simone EJ, Kamal DE, Gispen WH. The effect of gamma-linolenic acid–alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats. J Neurol Sci 2001; 182:99–106.

6. Shin CS, Lee MK, Park KS, Kim SY, Cho BY, Lee HK,

et al.

Insulin restores fatty acid composition earlier in liver microsomes than erythrocyte membranes in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 1995; 29:93-98.

7. Van BilsenM, DeVries JE, VanderVusse GJ. Long-term effects of fatty acids on cell viability and gene expression of neonatal cardiac myocytes. Prostaglandins Leukot Essent Fatty Acids 1997; 57: 39-45.

8. Van der Vusse GJ, Glatz JFC, Van Nieuwenhoven FA, Reneman RS, Bassingthwaighte JB. Transport of long-chain fatty acids across the muscular endothelium. Adv Exp Med Biol 1998; 441: 181-191.

9. Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campel LV. The relation between insulin sensitivity and the fatty acid composition of skeletal muscle. New Eng J Med 1993; 328:238- 244.

10. Fla´via RC, Seelaender MCL. Liver denervation affects hepatocyte mitochondrial fatty transport capacity. Cell Biochem Funct 2004; 22:9–17.

11. Poisson JPG, Cunnane SC. Long-chain fatty acid metabolim in fasting and diabetes-relation between altered desaturase activity and fatty-acid composition. J Nutr Biochem 1991; 2:60-70.

12. Mimouni V, Poisson JP. Altered desaturase activities and fatty acid composition in liver microsomes of spontaneously diabetic Wistar BB rat. Biochim Biophys Acta 1992; 1123:296-302.

13. Douillet C, Ciavatti M. Effect of vitamin E treatment on tissue fatty acids and cholesterol content in experimental diabetes. J Nutr Biochem 1995; 29:319-326.

14. Reche P, Perham RN. Structure and selectivity in post-translational modification: attaching the biotinyl-lysine and lipoyl-lysine swinging arms in multifunctional enzymes. EMBO J 1999; 18: 2673–2682.

15. Fang YZ, Yang S, Wu GY. Free radicals, antioxidants, and nutrition Nutrition 2002; 18:872-879.

16. Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ,

et al.

The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 1996; 45:1024-1029.

17. Slater TF. Free radical mechanisms in tissue injury. Biochem J 1984; 222:1–15.

18. Fang YZ, Yang S, Wu GY. Free radicals, antioxidants, and nutrition. Nutrition 2002; 18:872-879.

19. Huang HY, Appel LJ, Croft KD, Miller ER, Mori TA, Puddey IB. Effects of vitamin C and vitamin E on

in vivo

lipid peroxidation: results of a randomized controlled trial. Am J Clin Nutr 2002; 76:549-555.

20. Orzechowski A. Dietary prophylaxis as an alternative method for the prevention of the development of insulin resistance. Med Weter 2003; 59:767-772.

21. Folch JM, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226:497-509.

22. Christie WW. Gas Chromatography and Lipids. Glaskow: The Oil Press; 1992.p.302.

23. Katsanidus E, Addis PB. Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. Free Rad Biol Med 1999; 27:1137–1140.

24. Bragagnolo N, Rodriguez-Amaya DB. Comparison of the cholesterol content of Brazilian chicken and quail eggs. J Food Comp Analysis ?? 2003; 16: 147-153.

25. Serada TJ, Mant CT, Hodges RS. Use of sodium perchlorate at low pH for peptide separatios by reversed-phase liquid chromatography. Influence of perchlorate ion on apparent hydrophilicity of positively charged amino acid side-chains. J Chromatogr 1997; 776:153-165.

26. Yoshida T. Determination of reduced and oxidized glutathione in erythrocytes by high performance liquid chromatography with ultraviolet absorbance dedection. J Chromatogr B 1996; 678: 157-168.

27. Gallou G, Ruelland A, Legras B, Maugendre D, Allanic H, Cloarec L. Plasma malondialdehyde in type 1 and type 2 diabetic patients. Clin Chim Acta 1993; 214:227–234.

28. Mero N, Syvanne M, Taskinen MR. Postprandial lipid metabolism in diabetes. Atherosclerosis 1998; 141:53-55.

29. Steinberg HO, Baron AD. Vascular function, insulin resistance and fatty acids. Diabetologia 2002; 45:623–634.

30. Paolisso G, D’Amore A, Giugliano D, Ceriello A, Varricchio M, D’Onofrio F. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 1993; 57:650–656.

31. Teupser D, Thiery J, Seidel D. Alpha-tocopherol down-regulates scavenger receptor activity in macrophages. Atherosclerosis

172

1999; 144:109–115.

32. Ricciarelli R, Zingg JM, Azzi A. Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation 2000; 102: 82–87.

33. Beutler E. Nutritional and metabolic aspects of glutathione. Ann Rew Nutr 1989; 9:287-302.

34. May JM, Qu ZC, Whitesell RR, Cobb CE. Ascorbate recycling in human erythrocytes: Role of GSH in reducing dehydroascorbate. Free Rad Biol Med 1996; 20:543-551.

35. Sies H. Glutathione and its role in cellular functions. Free Rad Biol Med 1999; 27:916–921.

36. Packer L, Witt EH, Tritschler HJ. Alpha-Lipoic acid as a biological antioxidant. Free Rad Biol Med 1995; 19:227-250.

37. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Rad Biol Med 1997; 22:359-378.

38. Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 2001; 17:888–895.

39. Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W,

et al.

Oral administration of RAC-alphalipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Rad Biol Med 1999; 27:309–314.

40. Yilmaz O, Ozkan Y, Yıldırım M, Ozturk AI, Ersan Y. Effects of alpha lipoic acid, ascorbic acid-6-palmitate and fish oil on the glutathione, malonaldehyde and fatty acid levels in erythrocytes of streptozotocin induced diabetic male rats. J Cell Biochem 2002; 86:530-539.

41. Dincer Y, Telci A, Kayali R, Yilmaz IA, Cakatay U, Akcay T. Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats. Clin Exp Pharm Physiol 2002; 29: 281- 284.

42. Powell LA, Warpeha KM, Xu WM, Walker B, Trimble ER. High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells. J Mol Endocrinol 2004; 33:797-803.

43. Baydas G, Donder E, Kiliboz M, Sonkaya E, Tuzcu M, Yasar A,

et al.

Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes. Biochem-Moscow 2004; 69:1001-1005.

44. Mekinova D, Chorvathova V, Volkovova K, Staruchova M, Grancicova E, Klvanova J,

et al.

Effect of intake of exogenous vitamin C, Vitamin E and beta carotene on the antioxidative status in kidneys of rats with streptozotocin-induced diabetes. Nahrung 1995; 39:257-261.

45. Leonardo AE, Pereiraa SL, Sprecherb H, Huangam YS. Elongation of long-chain fatty acids. Prog Lipid Res 2004; 43:36–54.

46. Jones BH, Standridge MK, Claycombe KJ, Smith PJ, Moustaı¨d- Moussa N. Glucose induces expression of stearoyl-CoA desaturase in 3T3–L1 adipocytes. Biochem J 1998; 335:405–408.

47. Legrand P, Bensadoun A. Stearyl-CoA desaturase activity in cultured rat hepatocytes. Biochim Biophys Acta 1991; 1086:89–94.

48. Ntambi JM. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 1999; 40:1549-1558.

49. Quartacci MF, Cosi E, Navari-Izzo F. Lipids and NADPH dependent superoxide production in plasma membrane vesicles from roots of wheat grown in excess copper. J Exp Bot 2000; 52:77–84.

50. Brenner RR, Bernasconi AM, Garda HA. Effect of experimental diabetes on the fatty acid composition, molecular species of phosphatidyl-choline and physical properties of hepatic microsomal membranes. Prostaglandins Leukot Essent Fatty Acids 2000; 63:167-176.

51. Hu QZ, Ishii E, Nakawa Y. Differential changes in relative levels of arachidonic acid in major phospholipids from rat tissues during the progression of diabtestes. J Biochem 1994; 115:405-408.

52. Mohan IK, Das UN. Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids 2000; 62: 35-46.

53. Bassi A, Avogaro A, Crepaldi C, Pavan P, Zambon S, Marin R,

et al.

Short-term diabetic ketosis alters n-6 polyunsaturated fatty acid content in plasma phospholipids. J Clin Endocronol Metabol 1996; 81:1650-1653.

54. Koo JR, Ni ZM, Oviesi F, Vaziri ND. Antioxidant therapy potentiates antihypertensive action of insulin in diabetic rats. Clin Exp Hypertens 2002; 24:333-344.