سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Eskandari, Azam, Saatchian, Erfan, mohammadi, Mohammad Yasin, Momennezhad, Mehdi, hoseini, sare, Nasseri, Shahrokh, Homaei Shandiz, fatemeh, Gholamhosseinian, Hamid. (1404). Isodose Volume Analysis in Postoperative High-Dose-Rate Brachytherapy: A Study on Total-Reference-Air-Kerma Correlations and Organ-at-Risk Doses. , 22(6), 389-394. doi: 10.22038/ijmp.2025.90069.2592
Azam Eskandari; Erfan Saatchian; Mohammad Yasin mohammadi; Mehdi Momennezhad; sare hoseini; Shahrokh Nasseri; fatemeh Homaei Shandiz; Hamid Gholamhosseinian. "Isodose Volume Analysis in Postoperative High-Dose-Rate Brachytherapy: A Study on Total-Reference-Air-Kerma Correlations and Organ-at-Risk Doses". , 22, 6, 1404, 389-394. doi: 10.22038/ijmp.2025.90069.2592
Eskandari, Azam, Saatchian, Erfan, mohammadi, Mohammad Yasin, Momennezhad, Mehdi, hoseini, sare, Nasseri, Shahrokh, Homaei Shandiz, fatemeh, Gholamhosseinian, Hamid. (1404). 'Isodose Volume Analysis in Postoperative High-Dose-Rate Brachytherapy: A Study on Total-Reference-Air-Kerma Correlations and Organ-at-Risk Doses', , 22(6), pp. 389-394. doi: 10.22038/ijmp.2025.90069.2592
Eskandari, Azam, Saatchian, Erfan, mohammadi, Mohammad Yasin, Momennezhad, Mehdi, hoseini, sare, Nasseri, Shahrokh, Homaei Shandiz, fatemeh, Gholamhosseinian, Hamid. Isodose Volume Analysis in Postoperative High-Dose-Rate Brachytherapy: A Study on Total-Reference-Air-Kerma Correlations and Organ-at-Risk Doses. , 1404; 22(6): 389-394. doi: 10.22038/ijmp.2025.90069.2592

Isodose Volume Analysis in Postoperative High-Dose-Rate Brachytherapy: A Study on Total-Reference-Air-Kerma Correlations and Organ-at-Risk Doses

Iranian Journal of Medical Physics
مقاله 3، دوره 22، شماره 6، بهمن و اسفند 2025، صفحه 389-394    اصل مقاله (1.18 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2025.90069.2592
نویسندگان
Azam Eskandari1؛ Erfan Saatchian2؛ Mohammad Yasin mohammadi1؛ Mehdi Momennezhad3؛ sare hoseini4؛ Shahrokh Nasseri5؛ fatemeh Homaei Shandiz4؛ Hamid Gholamhosseinian* 5
1Department of medical physics, Mashhad University of Medical sciences, Mashhad, Iran
2medical physics department, medical faculty, Mashhad University of Medical Sciences, Mashhad, Iran.
3Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: High-Dose-Rate (HDR) Vaginal Brachytherapy (VBT) is a standard adjuvant treatment for early-stage endometrial cancer following surgery. While the Total-Reference-Air-Kerma (TRAK) reflects the overall radiation output, its relationship with the actual irradiated tissue volumes and Organ-At-Risk (OAR) exposure remains underexplored in treatments using cylindrical applicators. The aim of this study is to evaluate the correlation between TRAK, irradiated volumes, and doses to OARs.
Material and Methods: This retrospective study included 28 Iranian women with histologically confirmed endometrial carcinoma postoperatively treated with HDR brachytherapy using single-channel vaginal cylinder applicators. CT-based treatment planning was performed using Elekta Oncentra software. Prescribed doses were delivered over three weekly fractions. The volumes enclosed by the prescribed isodose surface (VISV) were quantified using 3D Slicer software. TRAK, dosimetric parameters (D90%, D2cc, D0.1cc), and VISV were analyzed. The geometric volume of the applicator was subtracted to determine the actual irradiated tissue volume. Statistical analysis involved Pearson and Spearman correlation coefficients.
Results: The mean TRAK was calculated as 0.45 ± 0.06 cGy·m². A significant positive correlation (R²=0.981) was found between TRAK/dprescribed and the irradiated volume (VISV). No significant correlation was observed between TRAK and D2cc doses for the bladder and rectum (R²=0.075 and 0.46).
Conclusion: This study demonstrates a strong association between TRAK and isodose volumes in HDR brachytherapy, suggesting TRAK could be a surrogate for overall dose delivery. However, its lack of correlation with OAR dose metrics emphasizes the need for comprehensive (Dose-Volume-Histogram) DVH assessments. Future research may explore incorporating TRAK into models for predicting toxicity and outcomes, enhancing brachytherapy planning and monitoring.
کلیدواژه‌ها
Endometrial Neoplasms؛ Brachytherapy؛ Radiotherapy؛ Isodose Surface Volume؛ Total Reference Air Kerma
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