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Elbaz, Gad, Hassan, Ibrahim, Ereiba, Khairy, Attalla, Ehab. (1404). Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy. , 22(6), 377-388. doi: 10.22038/ijmp.2025.88946.2568
Gad yahia Elbaz; Ibrahim Mohamed Hassan; Khairy Mohamed Ereiba; Ehab Marouf Attalla. "Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy". , 22, 6, 1404, 377-388. doi: 10.22038/ijmp.2025.88946.2568
Elbaz, Gad, Hassan, Ibrahim, Ereiba, Khairy, Attalla, Ehab. (1404). 'Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy', , 22(6), pp. 377-388. doi: 10.22038/ijmp.2025.88946.2568
Elbaz, Gad, Hassan, Ibrahim, Ereiba, Khairy, Attalla, Ehab. Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy. , 1404; 22(6): 377-388. doi: 10.22038/ijmp.2025.88946.2568

Dosimetric and Biological Outcomes of Gamma Knife Radiosurgery and Volumetric Modulated Arc Therapy

Iranian Journal of Medical Physics
مقاله 2، دوره 22، شماره 6، بهمن و اسفند 2025، صفحه 377-388    اصل مقاله (1.46 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2025.88946.2568
نویسندگان
Gad yahia Elbaz* 1؛ Ibrahim Mohamed Hassan2؛ Khairy Mohamed Ereiba3؛ Ehab Marouf Attalla4
1Biophysics branch,Physics department,faculty of Science AL-Azhar university,Cairo,Egypt.
2Physics Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
3Physics Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
4National Cancer Institute, Cairo University, Giza, Egypt.
چکیده
Introduction: This research aimed to evaluate the radiation-induced secondary cancer risks in normal tissues following Gamma Knife Radiosurgery (GKR) compared with the Volumetric-Modulated Arc Therapy (VMAT).
Material and Methods: Eleven patients with meningioma (2 males, 9 females; median age 30 years) were analyzed. For each case, Gamma Knife radiosurgery (GKR) and volumetric modulated arc therapy (VMAT) plans were created and compared using dosimetric-metrics and radiobiological modeling. The Organ Equivalent Dose (OED) was estimated using linear, linear-exponential, and plateau dose–response models, and the Excess Absolute Risk (EAR) was calculated for organs at risk to estimate secondary cancer risk.
Results: Dose coverage, conformity, and homogeneity in the Planning Target Volume (PTV) improved significantly ('p'< 0.05) with GKR and VMAT. Higher OED was observed in the optic nerve due to proximity to the target. While the EAR of the optic nerve increased by 11.23%, 13.17%, and 14.86% in GK compared to VMAT for the linear, plateau, as well as linear-exponential models, respectively, in GK plans compared to VMAT, the EAR for the brain stem increased by 54.4%, 17.14%, and 30% in VMAT. GKR had a considerably greater Tumor Control Probability (TCP) (95.76%±2.86) than VMAT (84.29%± 2.27, 'p'= 2.8×10-6).
Conclusion: GKR provided better PTV dose coverage and conformity, whereas VMAT achieved superior dose homogeneity. According to EAR, VMAT had a greater second cancer risk than GK. For young patients, advanced radiotherapy techniques should be evaluated in consideration of dosimetric, radiobiological, and secondary cancer risks.
کلیدواژه‌ها
Second Cancer risk؛ GKR؛ VMAT؛ TCP؛ NTCP؛ Meningioma
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