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Talebi, Asra Sadat, Bodaghi Hosseinabadi, Roghiye, Abouie Mehrizi, Omid. (1404). Dose Verification in Lung Radiotherapy Using PET Imaging of Nanoparticle-Induced Positrons. , 22(6), 369-376. doi: 10.22038/ijmp.2026.92153.2636
Asra Sadat Talebi; Roghiye Bodaghi Hosseinabadi; Omid Abouie Mehrizi. "Dose Verification in Lung Radiotherapy Using PET Imaging of Nanoparticle-Induced Positrons". , 22, 6, 1404, 369-376. doi: 10.22038/ijmp.2026.92153.2636
Talebi, Asra Sadat, Bodaghi Hosseinabadi, Roghiye, Abouie Mehrizi, Omid. (1404). 'Dose Verification in Lung Radiotherapy Using PET Imaging of Nanoparticle-Induced Positrons', , 22(6), pp. 369-376. doi: 10.22038/ijmp.2026.92153.2636
Talebi, Asra Sadat, Bodaghi Hosseinabadi, Roghiye, Abouie Mehrizi, Omid. Dose Verification in Lung Radiotherapy Using PET Imaging of Nanoparticle-Induced Positrons. , 1404; 22(6): 369-376. doi: 10.22038/ijmp.2026.92153.2636

Dose Verification in Lung Radiotherapy Using PET Imaging of Nanoparticle-Induced Positrons

Iranian Journal of Medical Physics
مقاله 1، دوره 22، شماره 6، بهمن و اسفند 2025، صفحه 369-376    اصل مقاله (1.77 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2026.92153.2636
نویسندگان
Asra Sadat Talebi* 1؛ Roghiye Bodaghi Hosseinabadi2؛ Omid Abouie Mehrizi3
1Department of Medical Physics, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran.
2Department of Medical Physics, Hamadan University of Medical Sciences, Hamadan, Iran
3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Introduction: Accurate verification of radiation dose delivery remains a major challenge in radiotherapy. Positron emission tomography (PET) imaging of megavoltage (MV)-induced positrons (MVIPET) has recently emerged as a potential in vivo dosimetry technique. In this study, we investigated the feasibility of enhancing MVIPET signals using high-Z nanoparticles (NPs), specifically platinum (Pt) and silver (Ag), to enable real-time dose monitoring during lung radiotherapy.
Material and Methods: PET images arising from positrons induced by platinum and silver nanoparticles in a lung tumor were generated during radiotherapy with 6, 10, and 15 MV photon beams using the GATE Monte Carlo code. The resulting images were evaluated for both image quality and dose verification.
Results: Results showed that positron production, absorbed dose, and PET signal intensity increased with both photon beam energy and NP concentration, with PtNPs producing significantly higher enhancement than AgNPs. High-quality MVIPET images with acceptable SBR and CNR, and low RMSE, were obtained for PtNP concentrations ≥8 wt% at 10 MV and ≥4 wt% at 15 MV. In contrast, AgNPs required higher concentrations and only yielded reliable monitoring at 15 MV. At 6 MV, image quality and dose–image correlation were insufficient for clinical feasibility.
Conclusion: These findings demonstrate that MVIPET, particularly when combined with PtNPs and higher photon energies, is a promising strategy for real-time, non-invasive dose verification in lung radiotherapy.
کلیدواژه‌ها
PET؛ Dosimetry؛ Radiation Therapy؛ Nanoparticle؛ Monte Carlo
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