[1]      Zhou P, Yang X Lou, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;

[2]      Bahareh Payvar, Azami S, Khodadadegan MA, Saburi E, Negah SS, Hajali V. Clinical characteristics of COVID-19 patients in Musa Ibn Jafar Hospital in Quchan: an observational study. NavideNo. 2022;25(83).

[3]      Graham RL, Donaldson EF, Baric RS. A decade after SARS: Strategies for controlling emerging coronaviruses. Vol. 11, Nature Reviews Microbiology. 2013.

[4]      Saeed Eftekharnasab VH. Sex and gender differences in COVID-19 cardiovascular complication: a narrative review. Navid No. 2024;27(9):34–50.

[5]      Griffith DM, Sharma G, Holliday CS, Enyia OK, Valliere M, Semlow AR, et al. Men and COVID-19: A biopsychosocial approach to understanding sex differences in mortality and recommendations for practice and policy interventions. Vol. 17, Preventing Chronic Disease. 2020.

[6]      Barber SJ, Kim H. COVID-19 Worries and Behavior Changes in Older and Younger Men and Women. Journals Gerontol - Ser B Psychol Sci Soc Sci. 2021;76(2).

[7]      Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, et al. COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options. Vol. 116, Cardiovascular Research. 2020.

[8]      Gebhard C, Regitz-Zagrosek V, Neuhauser HK, Morgan R, Klein SL. Impact of sex and gender on COVID-19 outcomes in Europe. Vol. 11, Biology of Sex Differences. 2020.

[9]      Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun. 2020;11(1).

[10]    Regitz-Zagrosek V, Kararigas G. Mechanistic pathways of sex differences in cardiovascular disease. Physiol Rev. 2017;97(1).

[11]    Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome [published correction appears in Lancet Respir Med. 2020 Feb 25;:]. Lancet Respir Med. 2020;8(4):420-422. doi:10.1016/S2213-2600(20)30076-X. Lancet Respir Med. 2020;8(feb 25).

[12]    Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Heal. 2020;8.

[13]    Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. BMJ. 2020;368.

[14]    Report on the epidemiological features of coronavirus disease 2019 (covid-19) outbreak in the republic of korea from january 19 to march 2, 2020. J Korean Med Sci. 2020;35(10).

[15]    Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy findings and venous thromboembolism in patients with COVID-19: A prospective cohort study. Ann Intern Med. 2020;173(4).

[16]    Fairweather D, Beetler DJ, Musigk N, Heidecker B, Lyle MA, Cooper LT, et al. Sex and gender differences in myocarditis and dilated cardiomyopathy: An update. Front Cardiovasc Med. 2023;10.

[17]    Gagliano-Jucá T, Basaria S. Testosterone replacement therapy and cardiovascular risk. Vol. 16, Nature Reviews Cardiology. 2019.

[18]    50/50 GH, And  the AP, International RC and the, Women., On C for R. Global Health 50/50. 2020. The Sex, Gender and COVID-19 Project.

[19]    Ahmed SB, Dumanski SM. Sex, gender and COVID-19: a call to action. Can J Public Heal. 2020;111(6).

[20]    Wehbe Z, Hammoud SH, Yassine HM, Fardoun M, El-Yazbi AF, Eid AH. Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality. Vol. 12, Frontiers in Immunology. 2021.

[21]    Schurz H, Salie M, Tromp G, Hoal EG, Kinnear CJ, Möller M. The X chromosome and sex-specific effects in infectious disease susceptibility. Vol. 13, Human genomics. 2019.

[22]    Klein SL, Flanagan KL. Sex differences in immune responses. Vol. 16, Nature Reviews Immunology. 2016.

[23]    Moulton VR. Sex hormones in acquired immunity and autoimmune disease. Vol. 9, Frontiers in Immunology. 2018.

[24]    Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, et al. Sex-specific adipose tissue imprinting of regulatory T cells. Nature. 2020;579(7800).

[25]    Márquez EJ, Chung C han, Marches R, Rossi RJ, Nehar-Belaid D, Eroglu A, et al. Sexual-dimorphism in human immune system aging. Nat Commun. 2020;11(1).

[26]    Gal-Oz ST, Maier B, Yoshida H, Seddu K, Elbaz N, Czysz C, et al. ImmGen report: sexual dimorphism in the immune system transcriptome. Nat Commun. 2019;10(1).

[27]    Griesbeck M, Tomezsko P, Doyle E, Sirignano M, Diefenbach T, Altfeld M, et al. Sex differences in IRF5 levels and implications for pDC IFNα response (P1365). J Immunol. 2013;190(1_Supplement).

[28]    Van Der Made CI, Simons A, Schuurs-Hoeijmakers J, Van Den Heuvel G, Mantere T, Kersten S, et al. Presence of Genetic Variants among Young Men with Severe COVID-19. JAMA - J Am Med Assoc. 2020;324(7).

[29]    Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. 2020;588(7837).

[30]    Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, et al. COVID-19 infection: the perspectives on immune responses. Vol. 27, Cell Death and Differentiation. 2020.

[31]    Liu B, Li M, Zhou Z, Guan X, Xiang Y. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? Vol. 111, Journal of Autoimmunity. 2020.

[32]    Liu F, Li L, Xu M Da, Wu J, Luo D, Zhu YS, et al. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J Clin Virol. 2020;127.

[33]    Ortona E, Pierdominici M, Maseli A, Veroni C, Aloisi F, Shoenfeld Y. Sex-based differences in autoimmune diseases. Ann Ist Super Sanita. 2016;52(2).

[34]    Romagnoli S, Peris A, De Gaudio AR, Geppetti P. SARS-CoV-2 and COVID-19: From the bench to the bedside. Vol. 100, Physiological Reviews. 2020.

[35]    Pradhan A, Olsson PE. Sex differences in severity and mortality from COVID-19: are males more vulnerable? Vol. 11, Biology of Sex Differences. 2020.

[36]    Ya’qoub L, Elgendy IY, Pepine CJ. Sex and gender differences in COVID-19: More to be learned! Am Hear J Plus Cardiol Res Pract. 2021;3.

[37]    Ciarambino T, Sansone G, Menna G, Para O, Giordano M. What is known in male gender differences, comorbidity and age for covid-19 pandemia? A narrative minireview. J Gerontol Geriatr. 2020;68(Special Issue 4).

[38]    Muther C, Jobeili L, Garion M, Heraud S, Thepot A, Damour O, et al. An expression screen for aged-dependent microRNAs identifies miR- 30a as a key regulator of aging features in human epidermis. Aging (Albany NY). 2017;9(11).

[39]    Vegeto E, Villa A, Della Torre S, Crippa V, Rusmini P, Cristofani R, et al. The role of sex and sex hormones in neurodegenerative diseases. Vol. 41, Endocrine Reviews. 2019.

[40]    Rozenberg S, Vandromme J, Charlotte M. Are we equal in adversity? Does Covid-19 affect women and men differently? Vol. 138, Maturitas. 2020.

[41]    Alsan M, Stantcheva S, Yang D, Cutler D. Disparities in coronavirus 2019 reported incidence, knowledge, and behavior among us adults. JAMA Netw Open. 2020;3(6).

[42]    Lakbar I, Luque-Paz D, Mege JL, Einav S, Leone M. COVID-19 gender susceptibility and outcomes: A systematic review. PLoS One. 2020;15(11 November).

[43]    Ortiz A, Cozzolino M, Duivenvoorden R, Fliser D, Fouque D, Franssen CFM, et al. Chronic kidney disease is a key risk factor for severe COVID-19: A call to action by the ERA-edta. Nephrol Dial Transplant. 2021;36(1).

[44]    Snell DM, Turner JMA. Sex Chromosome Effects on Male–Female Differences in Mammals. Vol. 28, Current Biology. 2018.

[45]    Robinson DP, Lorenzo ME, Jian W, Klein SL. Elevated 17β-estradiol protects females from influenza a virus pathogenesis by suppressing inflammatory responses. PLoS Pathog. 2011;7(7).

[46]    Nguyen DC, Masseoud F, Lu X, Scinicariello F, Sambhara S, Attanasio R. 17β-Estradiol restores antibody responses to an influenza vaccine in a postmenopausal mouse model. Vaccine. 2011;29(14).

[47]    Pazos MA, Kraus TA, Muñoz-Fontela C, Moran TM. Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice. PLoS One. 2012;7(7).

[48]    Vermillion MS, Ursin RL, Attreed SE, Klein SL. Estriol reduces pulmonary immune cell recruitment and inflammation to protect female mice from severe influenza. Endocrinology. 2018;159(9).

[49]    Channappanavar R, Fett C, Mack M, Ten Eyck PP, Meyerholz DK, Perlman S. Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. J Immunol. 2017;198(10).

[50]    Montopoli M, Zumerle S, Vettor R, Rugge M, Zorzi M, Catapano C V., et al. Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532). Ann Oncol. 2020;31(8).

[51]    Chakravarty D, Nair SS, Hammouda N, Ratnani P, Gharib Y, Wagaskar V, et al. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Vol. 3, Communications Biology. 2020.

[52]    Xudong X, Junzhu C, Xingxiang W, Furong Z, Yanrong L. Age- and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78(19).

[53]    Dalpiaz PLM, Lamas AZ, Caliman IF, Ribeiro RF, Abreu GR, Moyses MR, et al. Sex hormones promote opposite effects on ACE and ACE2 activity, hypertrophy and cardiac contractility in spontaneously hypertensive rats. PLoS One. 2015;10(5).

[54]    Araujo FC, Milsted A, Watanabe IKM, Del Puerto HL, Santos RAS, Lazar J, et al. Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. Physiol Genomics. 2015;47(5).

[55]    Liu J, Ji H, Zheng W, Wu X, Zhu JJ, Arnold AP, et al. Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent. Biol Sex Differ. 2010;1(1).

[56]    Costeira R, Lee KA, Murray B, Christiansen C, Castillo-Fernandez J, Lochlainn MN, et al. Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study. PLoS One. 2021;16(9 September).

[57]    Galasso V, Pons V, Profeta P, Becher M, Brouard S, Foucault M. Gender differences in COVID-19 attitudes and behavior: Panel evidence from eight countries. Proc Natl Acad Sci U S A. 2020;117(44).

[58]    Pivonello R, Auriemma RS, Pivonello C, Isidori AM, Corona G, Colao A, et al. Sex Disparities in COVID-19 Severity and Outcome: Are Men Weaker or Women Stronger? Neuroendocrinology. 2021;111(11).

[59]    Detopoulou P, Demopoulos CA, Antonopoulou S. Micronutrients, phytochemicals and mediterranean diet: A potential protective role against covid-19 through modulation of paf actions and metabolism. Vol. 13, Nutrients. 2021.

[60]    Moula AI, Micali LR, Matteucci F, Lucà F, Rao CM, Parise O, et al. Quantification of death risk in relation to sex, pre-existing cardiovascular diseases and risk factors in COVID-19 patients: Let’s take stock and see where we are. Vol. 9, Journal of Clinical Medicine. 2020.