Sundaram, Venugopal, D, KHANNA, P, Mohandass, Palanivel, Sathyaraj, S, Anto Vaz, D, Palanivel. (1404). Plan Quality and Optimized Treatment Planning Technique for Single-Isocenter VMAT Brain Stereotactic Radiosurgery/Radiotherapy Using Photon Optimizer. , 22(4), 247-260. doi: 10.22038/ijmp.2025.87088.2526
Venugopal Sundaram; KHANNA D; Mohandass P; Sathyaraj Palanivel; Anto Vaz S; Palanivel D. "Plan Quality and Optimized Treatment Planning Technique for Single-Isocenter VMAT Brain Stereotactic Radiosurgery/Radiotherapy Using Photon Optimizer". , 22, 4, 1404, 247-260. doi: 10.22038/ijmp.2025.87088.2526
Sundaram, Venugopal, D, KHANNA, P, Mohandass, Palanivel, Sathyaraj, S, Anto Vaz, D, Palanivel. (1404). 'Plan Quality and Optimized Treatment Planning Technique for Single-Isocenter VMAT Brain Stereotactic Radiosurgery/Radiotherapy Using Photon Optimizer', , 22(4), pp. 247-260. doi: 10.22038/ijmp.2025.87088.2526
Sundaram, Venugopal, D, KHANNA, P, Mohandass, Palanivel, Sathyaraj, S, Anto Vaz, D, Palanivel. Plan Quality and Optimized Treatment Planning Technique for Single-Isocenter VMAT Brain Stereotactic Radiosurgery/Radiotherapy Using Photon Optimizer. , 1404; 22(4): 247-260. doi: 10.22038/ijmp.2025.87088.2526

Plan Quality and Optimized Treatment Planning Technique for Single-Isocenter VMAT Brain Stereotactic Radiosurgery/Radiotherapy Using Photon Optimizer

Iranian Journal of Medical Physics
دوره 22، شماره 4، مهر و آبان 2025، صفحه 247-260    اصل مقاله (2.02 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2025.87088.2526
نویسندگان
Venugopal Sundaram* 1؛ KHANNA D2؛ Mohandass P3؛ Sathyaraj Palanivel4؛ Anto Vaz S5؛ Palanivel D6
1Division of Physical Sciences, Karunya Institute of Technology and Sciences, Coimbatore, Tamilnadu, India. Department of Radiation Oncology, Yashoda Super Specialty Hospital and Cancer Institute. Ghaziabad, U.P. India.
2Division of Physical Sciences, Karunya Institute of Technology and Sciences, Coimbatore, Tamilnadu, India.
3Department of Radiation Oncology, Fortis Hospital, Mohali, Punjab, India.
4Department of Radiation Oncology, Kidwai memorial institute of oncology center, Bengaluru, India.
51Division of Physical Sciences, Karunya Institute of Technology and Sciences, Coimbatore, Tamilnadu, India. 5Department of Radiation Oncology, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India.
61Division of Physical Sciences, Karunya Institute of Technology and Sciences, Coimbatore, Tamilnadu, India. 6Department of Radiation Oncology, Manipal hospital, bangalore, India.
چکیده
Introduction: This study aims to analyze different dosimetric indices using various formulae in cranial Stereotactic Radiosurgery/Radiotherapy treatment planning.
Material and Methods: 42 targets were constructed from 23 patients with brain metastases (≤30 cc) treated at our institution, selected for this study. The PTVs were generated using a 3.0 mm isotropic margin from the CTV. Sequential boost prescriptions of 5-15 Gy were delivered using 6 MV FFF beams with full, partial, and non-coplanar arcs. The Acuros XB algorithm with a 1.25 mm grid size was optimized to calculate the dose distribution. The Conformity Index Homogeneity Index, and Gradient Index were evaluated using a DVH with different mathematical formulae.
Results: RTOG, Van’t Riet, and Paddick, and the Inverse of RTOG values were close to 1.0. Whereas Lomax & Scheib and SALT were 0.92 ± 0.06, 0.94±0.05, respectively, they achieved lower than 1.0. The results of different types of HI values achieved similar ideal values. For GI data scored, each target is in the case of multiple lesions. The effective radius and modified GI results for the dose GI are 4.61 ± 1.12 and 4.28 ± 1.24, respectively.
Conclusion: This study analyzed various CI, HI, and GI definitions to assess dose distribution quality in brain SRS/SRT plans. CI, HI, and GI are valuable tools for evaluating treatment plans by quantifying conformity, dose uniformity, and dose gradient. However, these indices have limitations. Future research should investigate these correlations, linking CI, HI, and GI with local control rates and toxicity outcomes.
کلیدواژه‌ها
Radiosurgery Brain Neoplasms / secondary Radiotherapy Intensity؛ Modulated
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