Safardoost, Soheila, Askari, Vahid Reza, Rezaei kahkha, Morteza, Taraz Jamshidi, Shirin, karimi, mahdi, Gholamhosseinian, Hamid, Soleymanifard, Shokouhozamanozaman. (1404). Radioprotective Effect of Ferula Asafoetida Oleo-Gum Resin on Ionizing Radiation–Induced Oxidative Stress and Tissue Damage in Rats. , 22(4), 241-246. doi: 10.22038/ijmp.2023.71276.2258
Soheila Safardoost; Vahid Reza Askari; Morteza Rezaei kahkha; Shirin Taraz Jamshidi; mahdi karimi; Hamid Gholamhosseinian; Shokouhozamanozaman Soleymanifard. "Radioprotective Effect of Ferula Asafoetida Oleo-Gum Resin on Ionizing Radiation–Induced Oxidative Stress and Tissue Damage in Rats". , 22, 4, 1404, 241-246. doi: 10.22038/ijmp.2023.71276.2258
Safardoost, Soheila, Askari, Vahid Reza, Rezaei kahkha, Morteza, Taraz Jamshidi, Shirin, karimi, mahdi, Gholamhosseinian, Hamid, Soleymanifard, Shokouhozamanozaman. (1404). 'Radioprotective Effect of Ferula Asafoetida Oleo-Gum Resin on Ionizing Radiation–Induced Oxidative Stress and Tissue Damage in Rats', , 22(4), pp. 241-246. doi: 10.22038/ijmp.2023.71276.2258
Safardoost, Soheila, Askari, Vahid Reza, Rezaei kahkha, Morteza, Taraz Jamshidi, Shirin, karimi, mahdi, Gholamhosseinian, Hamid, Soleymanifard, Shokouhozamanozaman. Radioprotective Effect of Ferula Asafoetida Oleo-Gum Resin on Ionizing Radiation–Induced Oxidative Stress and Tissue Damage in Rats. , 1404; 22(4): 241-246. doi: 10.22038/ijmp.2023.71276.2258

Radioprotective Effect of Ferula Asafoetida Oleo-Gum Resin on Ionizing Radiation–Induced Oxidative Stress and Tissue Damage in Rats

Iranian Journal of Medical Physics
دوره 22، شماره 4، مهر و آبان 2025، صفحه 241-246    اصل مقاله (1.52 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22038/ijmp.2023.71276.2258
نویسندگان
Soheila Safardoost1؛ Vahid Reza Askari2؛ Morteza Rezaei kahkha3؛ Shirin Taraz Jamshidi4؛ mahdi karimi5؛ Hamid Gholamhosseinian6؛ Shokouhozamanozaman Soleymanifard* 7
1Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Patient Safety Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
5Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
6Medical Physics Dept, Faculty of Medicine, Mashhad University of Medical Sciences
7Associate Professor of Medical Physics, Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: Protective agents against harmful radiation have been studied for decades. Antioxidants can protect normal tissues by scavenging free radicals generated during irradiation. Ferula asafoetida (AS), a medicinal plant with antioxidant activity, was evaluated in this study for its protective effect against radiation-induced small intestinal injury in rats.
Material and Methods: Thirty-five Wistar rats were randomly divided into five groups (n=7): control, irradiated (R), irradiated+AS (R+AS), irradiated+vitamin E (R+E), and irradiated+AS+E (R+AS+E). Treatments included AS (100 mg/kg) and/or vitamin E (20 mg/kg) daily for eight days. On day six, irradiated groups received 6 Gy X-rays (6 MV, Elekta, Stockholm, Sweden). On day eight, rats were euthanized and intestine and liver tissues collected. Histopathology, malondialdehyde (MDA), and glutathione (GSH) levels were analyzed.
Results: AS significantly reduced MDA and increased GSH levels in both intestine and liver. Vitamin E showed weaker effects. The combination of AS and vitamin E did not consistently enhance AS activity. Histological analysis revealed that AS reduced inflammation and atrophy, while vitamin E alone or combined with AS lowered inflammation and epithelial erosion. Neither treatment increased mucous cell counts.
Conclusion: AS exerted notable antioxidant and radioprotective effects against intestinal damage in rats, indicating its potential as a natural agent for mitigating radiation-induced injury.
کلیدواژه‌ها
Ferula Asafoetida؛ Radiation Protection؛ Small Intestine؛ Vitamin E؛ Oxidative Stress
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