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Kavousi, Nasim, Bahreyni Toosi, mohammad taghi, Azimian, Hosein, Alibolandi, Mona. (1404). Silica-coated bismuth ferrite nanoparticles as novel radiosensitizers for cancer radiotherapy. , 13(1), 148-158. doi: 10.22038/nmj.2025.91064.2304
Nasim Kavousi; mohammad taghi Bahreyni Toosi; Hosein Azimian; Mona Alibolandi. "Silica-coated bismuth ferrite nanoparticles as novel radiosensitizers for cancer radiotherapy". , 13, 1, 1404, 148-158. doi: 10.22038/nmj.2025.91064.2304
Kavousi, Nasim, Bahreyni Toosi, mohammad taghi, Azimian, Hosein, Alibolandi, Mona. (1404). 'Silica-coated bismuth ferrite nanoparticles as novel radiosensitizers for cancer radiotherapy', , 13(1), pp. 148-158. doi: 10.22038/nmj.2025.91064.2304
Kavousi, Nasim, Bahreyni Toosi, mohammad taghi, Azimian, Hosein, Alibolandi, Mona. Silica-coated bismuth ferrite nanoparticles as novel radiosensitizers for cancer radiotherapy. , 1404; 13(1): 148-158. doi: 10.22038/nmj.2025.91064.2304

Silica-coated bismuth ferrite nanoparticles as novel radiosensitizers for cancer radiotherapy

Nanomedicine Journal
دوره 13، شماره 1، فروردین 2026، صفحه 148-158    اصل مقاله (1.49 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.91064.2304
نویسندگان
Nasim Kavousi1؛ mohammad taghi Bahreyni Toosi* 2؛ Hosein Azimian3؛ Mona Alibolandi4
1Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Medical Physics Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
3Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran and Medical Physics Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
4Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Radiotherapy is a cornerstone of cancer treatment; however, tumor radioresistance remains a major limitation. The use of radiosensitizers offers a strategy to selectively enhance the sensitivity of malignant cells to ionizing radiation while minimizing toxicity to surrounding normal tissues. In this study, we investigated the radiosensitizing potential of silica-coated bismuth ferrite nanoparticles (BFO-Si NPs).
Material and Methods: Bismuth ferrite nanoparticles (BFO NPs) were synthesized via the sol-gel method and coated with silica to produce BFO-Si NPs, and their morphology and structural properties were characterized using FESEM, EDS, HR-TEM, XRD, and DLS. Their cytotoxicity against human non-small cell lung carcinoma (NSCLC) SK-MES-1 cells was evaluated using the MTT assay. To further assess their efficacy as radiosensitizers, cell viability, colony-forming capacity, and apoptotic responses following X-ray irradiation were evaluated.
Results: The BFO-Si NPs exhibited uniform spherical geometry, a narrow size distribution, and good colloidal stability. They significantly increased apoptosis induction and decreased clonogenic survival of SK-MES-1 cells under 6 MV X-ray irradiation compared with radiation alone.
Conclusion: These findings demonstrate the potential of silica-coated bismuth ferrite nanoparticles as safe and effective radiosensitizers, capable of enhancing radiotherapeutic outcomes in NSCLC.
کلیدواژه‌ها
Bismuth compounds؛ Radiosensitizer؛ lung adenocarcinoma؛ Radiotherapy
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آمار
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