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saeidi, reza, Alizadeh, Parinaz, Kazemian, Mohammad, noripour, Shamsollah, fallahi, minoo. (1404). The effect of melatonin on the immune system and the treatment of neonatal sepsis. , 13(4), 235-239. doi: 10.22038/psj.2025.91025.1490
reza saeidi; Parinaz Alizadeh; Mohammad Kazemian; Shamsollah noripour; minoo fallahi. "The effect of melatonin on the immune system and the treatment of neonatal sepsis". , 13, 4, 1404, 235-239. doi: 10.22038/psj.2025.91025.1490
saeidi, reza, Alizadeh, Parinaz, Kazemian, Mohammad, noripour, Shamsollah, fallahi, minoo. (1404). 'The effect of melatonin on the immune system and the treatment of neonatal sepsis', , 13(4), pp. 235-239. doi: 10.22038/psj.2025.91025.1490
saeidi, reza, Alizadeh, Parinaz, Kazemian, Mohammad, noripour, Shamsollah, fallahi, minoo. The effect of melatonin on the immune system and the treatment of neonatal sepsis. , 1404; 13(4): 235-239. doi: 10.22038/psj.2025.91025.1490

The effect of melatonin on the immune system and the treatment of neonatal sepsis

Journal of Patient Safety & Quality Improvement
دوره 13، شماره 4، دی 2025، صفحه 235-239    اصل مقاله (269.11 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/psj.2025.91025.1490
نویسندگان
reza saeidi* 1؛ Parinaz Alizadeh2؛ Mohammad Kazemian2؛ Shamsollah noripour2؛ minoo fallahi2
1Neonatal Health Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Neonatal Health Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Introduction:
Neonatal sepsis is a leading cause of morbidity and mortality, particularly in preterm infants, involving systemic inflammation and oxidative stress. Melatonin, with its antioxidant, anti-inflammatory, and immunomodulatory properties, has emerged as a potential adjuvant to standard antibiotic therapy. This systematic review and meta-analysis synthesizes evidence from randomized controlled trials (RCTs) and clinical studies from 2000 to 2025 evaluating melatonin's efficacy and safety in neonatal sepsis.
Materials and Methods:
Databases including PubMed, Embase, Cochrane Library, Web of Science, Scopus, and ClinicalTrials.gov were searched for RCTs and trials on melatonin as adjuvant in neonatal sepsis. Inclusion: studies 2000-2025, neonates (<28 days), confirmed sepsis, melatonin vs. control (antibiotics alone). Outcomes: biomarkers (C-reactive protein or CRP, Malondialdehyde or MDA, Interlukine or IL-6/8), sepsis scores, mortality, hospital stay, adverse events.
Results:
Nine RCTs (n=354 neonates) included. Melatonin (typically 20 mg oral, single or divided) reduced CRP at 24h (P<0.001) and MDA (P<0.001). Improved sepsis recovery at 72h (P<0.001). Mortality lower (P<0.001), no adverse events. Preterm subgroup showed enhanced benefits.
Conclusions:
Melatonin improves biomarkers and outcomes in neonatal sepsis safely, but Larger RCTs needed for confirmation and dosing.
کلیدواژه‌ها
Melatonin؛ neonatal sepsis؛ adjuvant therapy
مراجع
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