سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Shahbaz, Yashar, Ali, Taimoor, Nouralishahi, Atieh, Ansari, Kazem, Usman, Salwa, Mohtashim Ali, Syed Mohammad, Zarenezhad, Mohammad, Taheri, Lohrasb, Shafa, Shahram, Deilami, Mansoor. (1404). Drug Repurposing for Frozen Shoulder; a Bioinformatics Meta-Analysis. , 13(11), 704-710. doi: 10.22038/abjs.2025.78385.3609
Yashar Shahbaz; Taimoor Ali; Atieh Nouralishahi; Kazem Ansari; Salwa Usman; Syed Mohammad Mohtashim Ali; Mohammad Zarenezhad; Lohrasb Taheri; Shahram Shafa; Mansoor Deilami. "Drug Repurposing for Frozen Shoulder; a Bioinformatics Meta-Analysis". , 13, 11, 1404, 704-710. doi: 10.22038/abjs.2025.78385.3609
Shahbaz, Yashar, Ali, Taimoor, Nouralishahi, Atieh, Ansari, Kazem, Usman, Salwa, Mohtashim Ali, Syed Mohammad, Zarenezhad, Mohammad, Taheri, Lohrasb, Shafa, Shahram, Deilami, Mansoor. (1404). 'Drug Repurposing for Frozen Shoulder; a Bioinformatics Meta-Analysis', , 13(11), pp. 704-710. doi: 10.22038/abjs.2025.78385.3609
Shahbaz, Yashar, Ali, Taimoor, Nouralishahi, Atieh, Ansari, Kazem, Usman, Salwa, Mohtashim Ali, Syed Mohammad, Zarenezhad, Mohammad, Taheri, Lohrasb, Shafa, Shahram, Deilami, Mansoor. Drug Repurposing for Frozen Shoulder; a Bioinformatics Meta-Analysis. , 1404; 13(11): 704-710. doi: 10.22038/abjs.2025.78385.3609

Drug Repurposing for Frozen Shoulder; a Bioinformatics Meta-Analysis

The Archives of Bone and Joint Surgery
مقاله 5، دوره 13، شماره 11، بهمن 2025، صفحه 704-710    اصل مقاله (950.73 K)
نوع مقاله: RESEARCH PAPER
شناسه دیجیتال (DOI): 10.22038/abjs.2025.78385.3609
نویسندگان
Yashar Shahbaz1؛ Taimoor Ali2؛ Atieh Nouralishahi3؛ Kazem Ansari4؛ Salwa Usman5؛ Syed Mohammad Mohtashim Ali6؛ Mohammad Zarenezhad7؛ Lohrasb Taheri8؛ Shahram Shafa* 9؛ Mansoor Deilami10
1Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of orthopaedic surgery, Dow University of health sciences, civil hospital, karachi, Pakistan
3Sub-Department of Operations and Analytics, Department of Management, Faculty of Environment, Science and Economy, University of Exeter Exeter, UK
4Shahid Sadoughi University of Medical Sciences, Yazd, Iran
55 Department of Family Medicine, Hamdard Health, Chicago, IL United States
6Department of Orthopaedic surgery, Children's health Ireland hospital, Dublin, Ireland
7Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
8Department of Surgery, School of Medicine, Peymanie Hospital, Jahrom University of Medical Sciences, Iran
9Department of Orthopedics, School of Medicine, Peymanie Hospital, Jahrom University of Medical Sciences, Iran
10Department of Anesthesiology and Critical Care, School of Medicine, 5th Azar Hospital, Sayyad Shirazi Hospital, Golestan University of Medical Sciences, Golestan, Iran
چکیده
Objectives: Adhesive capsulitis (AC), commonly known as frozen shoulder (FS), is characterized by glenohumeral joint capsule contraction, resulting in pain, stiffness, and dysfunction. Genetic factors have been implicated in the etiology of AC, prompting a bioinformatics investigation to explore potential therapeutic targets.
Methods: A systematic review of Gene Expression Omnibus (GEO) datasets was conducted using keywords related to Frozen Shoulder and Adhesive Capsulitis. The gene expression profiles from GSE238052, GSE190023, and GSE140731 were analyzed using the i-DEP package. Differential gene expression analysis, Gene Ontology (GO) enrichments, and drug-gene enrichments were performed through biclustering of GO pathways with the Drug.GeneSet database and dpGSEA Python application.
Results: Among 58,825 genes in 67 samples, 1,036 upregulated and 378 downregulated genes were identified in the case-control comparison. Upregulated pathways included skeletal muscle adaptation, fiber transition, myofibril assembly, and regulation of muscle fiber development. Drug.GeneSet database analysis highlighted adenosine and its derivatives as potential therapeutic targets. Further dpGSEA analysis revealed a significant influence of adenosine on the disease.
Conclusion: This study provides information about the genomic landscape of adhesive capsulitis, identifying potential therapeutic avenues centered around adenosine-related interventions. While topical or intra-articular injection of adenosine is evident in the literature, this finding should be validated through experimental studies.
        Level of evidence: V
کلیدواژه‌ها
Adhesive capsulitis؛ Bioinformatics analysis؛ Frozen shoulder؛ Gene expression omnibus
مراجع
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