سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Yaseen Khan, Furqan Mohammed, Razzaghof, Mohammadreza, Barzegar, Mohammad Reza, Shahpari, Omid, Abbaszadeh, Ahmad, Ghasemi, Mohammad Ali, Shafiei, Seyyed Hossein, Mortazavi, SM Javad. (1404). Safety and Efficacy of Aspirin in Thromboprophylaxis After Total Hip Arthroplasty: A Retrospective Study. , 13(11), 720-725. doi: 10.22038/abjs.2025.71614.3346
Furqan Mohammed Yaseen Khan; Mohammadreza Razzaghof; Mohammad Reza Barzegar; Omid Shahpari; Ahmad Abbaszadeh; Mohammad Ali Ghasemi; Seyyed Hossein Shafiei; SM Javad Mortazavi. "Safety and Efficacy of Aspirin in Thromboprophylaxis After Total Hip Arthroplasty: A Retrospective Study". , 13, 11, 1404, 720-725. doi: 10.22038/abjs.2025.71614.3346
Yaseen Khan, Furqan Mohammed, Razzaghof, Mohammadreza, Barzegar, Mohammad Reza, Shahpari, Omid, Abbaszadeh, Ahmad, Ghasemi, Mohammad Ali, Shafiei, Seyyed Hossein, Mortazavi, SM Javad. (1404). 'Safety and Efficacy of Aspirin in Thromboprophylaxis After Total Hip Arthroplasty: A Retrospective Study', , 13(11), pp. 720-725. doi: 10.22038/abjs.2025.71614.3346
Yaseen Khan, Furqan Mohammed, Razzaghof, Mohammadreza, Barzegar, Mohammad Reza, Shahpari, Omid, Abbaszadeh, Ahmad, Ghasemi, Mohammad Ali, Shafiei, Seyyed Hossein, Mortazavi, SM Javad. Safety and Efficacy of Aspirin in Thromboprophylaxis After Total Hip Arthroplasty: A Retrospective Study. , 1404; 13(11): 720-725. doi: 10.22038/abjs.2025.71614.3346

Safety and Efficacy of Aspirin in Thromboprophylaxis After Total Hip Arthroplasty: A Retrospective Study

The Archives of Bone and Joint Surgery
مقاله 7، دوره 13، شماره 11، بهمن 2025، صفحه 720-725    اصل مقاله (646.67 K)
نوع مقاله: RESEARCH PAPER
شناسه دیجیتال (DOI): 10.22038/abjs.2025.71614.3346
نویسندگان
Furqan Mohammed Yaseen Khan1؛ Mohammadreza Razzaghof2؛ Mohammad Reza Barzegar3؛ Omid Shahpari4؛ Ahmad Abbaszadeh1؛ Mohammad Ali Ghasemi5؛ Seyyed Hossein Shafiei6؛ SM Javad Mortazavi* 2
11 Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran
2Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran -Department of Orthopedic Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3Orthopedic Surgery Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6Orthopedic Surgery Research Center, Sina University Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objectives: This study aimed to evaluate the safety and efficacy of aspirin as a standalone thromboprophylaxis (TP) treatment following elective total hip arthroplasty (THA). Additionally, it compares the primary and secondary outcomes related to efficacy and safety, respectively, between aspirin and enoxaparin.
Methods: A retrospective review was conducted of 2,107 patients who underwent primary or revision total hip arthroplasty (THA) between 2011 and 2017. Low-risk patients received aspirin (325 mg twice daily for 4 weeks), while high-risk patients were administered enoxaparin (4,000 units once daily for 2 weeks). The outcomes assessed included symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE), hematoma, bleeding, infection, and 90-day mortality.
Results: The incidence of symptomatic deep vein thrombosis (DVT) requiring treatment in the aspirin group was 0.10% (2/1,905), whereas no cases were observed in the enoxaparin group. The rate of fatal pulmonary embolism (PE) was 0.05% (1/1,905) in the aspirin group, compared to 0.49% (1/202) in the enoxaparin group. Gastrointestinal (GI) bleeding occurred in 0.05% (1/1,905) of the aspirin group and 0.49% (1/202) of the enoxaparin group. The incidence of periprosthetic joint infection (PJI) was 0.15% (3/1,905) in the aspirin group, compared to 0.49% (1/202) in the enoxaparin group.
Conclusion: As a standalone TP agent, aspirin is at least as effective as potent anticoagulants for patients undergoing elective THA, with comparable safety and efficacy profiles.
        Level of evidence: IV
کلیدواژه‌ها
Aspirin؛ Enoxaparin؛ Hip arthroplasty؛ Thromboprophylaxis؛ Venous thromboembolism
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