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Verma, Jaya, Shekhar, Saurabh, ,, Monika, Jhawat, Vikas, Chauhan, Mahima, ,, Sonali,, Singh, Rahul Pratap. (1404). Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies. , 13(1), 210-223. doi: 10.22038/nmj.2025.82111.2045
Jaya Verma; Saurabh Shekhar; Monika ,; Vikas Jhawat; Mahima Chauhan; Sonali, ,; Rahul Pratap Singh. "Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies". , 13, 1, 1404, 210-223. doi: 10.22038/nmj.2025.82111.2045
Verma, Jaya, Shekhar, Saurabh, ,, Monika, Jhawat, Vikas, Chauhan, Mahima, ,, Sonali,, Singh, Rahul Pratap. (1404). 'Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies', , 13(1), pp. 210-223. doi: 10.22038/nmj.2025.82111.2045
Verma, Jaya, Shekhar, Saurabh, ,, Monika, Jhawat, Vikas, Chauhan, Mahima, ,, Sonali,, Singh, Rahul Pratap. Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies. , 1404; 13(1): 210-223. doi: 10.22038/nmj.2025.82111.2045

Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies

Nanomedicine Journal
دوره 13، شماره 1، فروردین 2026، صفحه 210-223    اصل مقاله (1.01 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2025.82111.2045
نویسندگان
Jaya Verma1؛ Saurabh Shekhar1؛ Monika ,1؛ Vikas Jhawat1؛ Mahima Chauhan1؛ Sonali, ,2؛ Rahul Pratap Singh* 1
1Department of Pharmacy, School of Healthcare and Allied Sciences, GD Goenka University, Sohna, Gurugram Road, Haryana, India
2Department of Pharmacy, Guru Teg Bahadur Hospital, Dilshad Garden, Delhi, India
چکیده
Objective(s): The primary objective of this study was to develop a sustained-release formulation of cefpodoxime proxetil (CP) using the polymer Eudragit RS 100 (ERS100).
Materials and Methods: Pluronic F127 (PF127) was incorporated as an amphiphilic surfactant to enhance product stability. Preformulation evaluations, including UV-visible spectroscopy and Fourier-transform infrared spectroscopy (FTIR), were performed to assess the compatibility of the drug, polymer, and their 1:1 mixture. Nanoparticles were formulated using the solvent evaporation technique, followed by continuous stirring of the emulsion during the removal of the organic solvent.
Results: The optimized formulation exhibited a particle size of less than 200 nm and an entrapment efficiency of 81.45 ± 0.891% for CP. In vitro drug release studies revealed sustained-release behavior, with the release kinetics best fitting the Higuchi (R² = 0.9757) and Hixson–Crowell (R² = 0.9707) models. Stability studies confirmed compliance with ICH guidelines regarding temperature and humidity conditions. These findings underscore the potential of CP-loaded nanoparticles as efficient carriers for sustained drug delivery, particularly targeting lung tissues.
Conclusion: The developed ERS100-based CP nanoparticles offer promising therapeutic benefits, including improved patient adherence through extended drug release intervals.
کلیدواژه‌ها
Cefpodoxime proxetil؛ Drug delivery systems؛ Drug stability؛ Eudragit RS100؛ Nanoparticles
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