سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Sharghilavan, Sara, Mehdizadeh Fanid, Leila, Geman, Oana, Shahrokhi, Hassan, Seyedarabi, Hadi. (1404). Exploring Hemispheric Contributions in the Processing of Social Speech in Autism. , 13(9), 19650-19660. doi: 10.22038/jpp.2025.90441.5589
Sara Sharghilavan; Leila Mehdizadeh Fanid; Oana Geman; Hassan Shahrokhi; Hadi Seyedarabi. "Exploring Hemispheric Contributions in the Processing of Social Speech in Autism". , 13, 9, 1404, 19650-19660. doi: 10.22038/jpp.2025.90441.5589
Sharghilavan, Sara, Mehdizadeh Fanid, Leila, Geman, Oana, Shahrokhi, Hassan, Seyedarabi, Hadi. (1404). 'Exploring Hemispheric Contributions in the Processing of Social Speech in Autism', , 13(9), pp. 19650-19660. doi: 10.22038/jpp.2025.90441.5589
Sharghilavan, Sara, Mehdizadeh Fanid, Leila, Geman, Oana, Shahrokhi, Hassan, Seyedarabi, Hadi. Exploring Hemispheric Contributions in the Processing of Social Speech in Autism. , 1404; 13(9): 19650-19660. doi: 10.22038/jpp.2025.90441.5589

Exploring Hemispheric Contributions in the Processing of Social Speech in Autism

Journal of Pediatric Perspectives
مقاله 2، دوره 13، شماره 9، آذر 2025، صفحه 19650-19660    اصل مقاله (444.86 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/jpp.2025.90441.5589
نویسندگان
Sara Sharghilavan* 1، 2؛ Leila Mehdizadeh Fanid1؛ Oana Geman2، 3، 4؛ Hassan Shahrokhi5؛ Hadi Seyedarabi6
1Department of Cognitive Neuroscience, Faculty of Education and Psychology, University of Tabriz, Tabriz, Iran.
2Data Science and AI, Computer Science and Engineering Department, Stefan cel Mare University of Suceava, Suceava, Romania.
3Data Science and AI, Computer Science and Engineering Department, Chalmers University of Technology.
4Data Science and AI, Computer Science and Engineering Department, University of Gothenburg, Gothenburg, Sweden.
5Autism and Related Neurodevelopmental Disorders Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.
6Faculty of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran.
چکیده
Background: Based on the lateralization of hemispheres in certain cognitive functions and the lack of knowledge of these dimensions in autism, this study aimed to compare the contribution of hemispheres to auditory spatial attention during socially relevant speech processing in children with autism compared to their typically developing peers (TD).
Methods: The participants were 27 Romanian children, including 12 children with autism and 15 typically developing children. Auditory stimuli were simple three-word Romanian sentences presented in an oddball pattern under three listening conditions: right ear, left ear, and binaural. We extracted the P300 event-related potential (ERP) component in response to all conditions and compared the two groups. Statistical analyses were performed using multivariate analysis of variance (MANOVA) with follow-up tests for between-subject effects.
Results: Multivariate analyses showed no significant overall differences across groups in the different conditions. However, between-subjects effects tests revealed a significant reduction in P300 amplitude for the left ear condition in the Autism spectrum disorder (ASD) group compared with TD peers (p = 0.042, partial η² = 0.155). Across all conditions, latency differences were not statistically significant.
Conclusion: The selective reduction in P300 amplitude for left ear input in children with ASD indicates reduced attentional engagement with socio-semantic aspects of speech that are predominantly processed in the right hemisphere. The findings emphasize the importance of lateralization-sensitive auditory patterns in understanding and addressing communication deficits in ASD.
کلیدواژه‌ها
Auditory Spatial Attention؛ Autism؛ Event-related potentials؛ Hemispheric lateralization؛ P300؛ Speech Processing
مراجع
  1. Belmonte MK, Cook EH, Anderson GM, Rubenstein JL, Greenough WT, Beckel-Mitchener A, Courchesne E, Boulanger LM, Powell SB, Levitt PR, Perry EK. Autism as a disorder of neural information processing: directions for research and targets for therapy. Molecular psychiatry. 2004 Jul;9(7):646-63.
  2. Dawson G, Toth K. Autism spectrum disorders. Developmental psychopathology: volume three: risk, disorder, and adaptation. 2015 Sep 5:317-57.
  3. Naji WA, Waheeb MQ, Hamza DH. Autism Spectrum Disorder. Medico-legal Update. 2020 Apr 1;20(2):321.
  4. Goncalves AM, Monteiro P. Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing. Journal of neural transmission. 2023 Mar;130(3):325-408.
  5. Zwaigenbaum L, Bryson S, Rogers T, Roberts W, Brian J, Szatmari P. Behavioral manifestations of autism in the first year of life. International journal of developmental neuroscience. 2005 Apr 1;23(2-3):143-52.
  6. Franchini M, Glaser B, Wood de Wilde H, Gentaz E, Eliez S, Schaer M. Social orienting and joint attention in preschoolers with autism spectrum disorders. PloS one. 2017 Jun 9;12(6):e0178859.
  7. Mundy P, Neal AR. Neural plasticity, joint attention, and a transactional social-orienting model of autism. InInternational review of research in mental retardation 2000 Jan 1 (Vol. 23, pp. 139-168). Academic Press.
  8. Chevallier C, Kohls G, Troiani V, Brodkin ES, Schultz RT. The social motivation theory of autism. Trends in cognitive sciences. 2012 Apr 1;16(4):231-9.
  9. Soskey LN, Allen PD, Bennetto L. Auditory spatial attention to speech and complex non‐speech sounds in children with autism spectrum disorder. Autism Research. 2017 Aug;10(8):1405-16.
  10. Voss P. Auditory spatial perception without vision. Frontiers in psychology. 2016 Dec 20;7:1960.
  11. Zatorre RJ, Belin P. Spectral and temporal processing in human auditory cortex. Cerebral cortex. 2001 Oct 1;11(10):946-53.
  12. Tervaniemi M, Hugdahl K. Lateralization of auditory-cortex functions. Brain research reviews. 2003 Dec 1;43(3):231-46.
  13. Friederici AD, Alter K. Lateralization of auditory language functions: a dynamic dual pathway model. Brain and language. 2004 May 1;89(2):267-76.
  14. Poeppel D. The neuroanatomic and neurophysiological infrastructure for speech and language. Current opinión in neurobiology. 2014 Oct 1;28:142-9.
  15. Teder-Sälejärvi WA, Pierce KL, Courchesne E, Hillyard SA. Auditory spatial localization and attention deficits in autistic adults. Cognitive Brain Research. 2005 May 1;23(2-3):221-34.
  16. Emmons KA, KC Lee A, Estes A, Dager S, Larson E, McCloy DR, et al. Auditory attention deployment in young adults with autism spectrum disorder. Journal of autism and developmental disorders. 2022 Apr;52(4):1752-61.
  17. Mihai AS, Geman O, Toderean R, Miron L, SharghiLavan S. The Next Frontier in Brain Monitoring: A Comprehensive Look at In-Ear EEG Electrodes and Their Applications. Sensors. 2025 May 25;25(11):3321.
  18. Jeste SS, Nelson III CA. Event related potentials in the understanding of autism spectrum disorders: an analytical review. Journal of autism and developmental disorders. 2009 Mar;39(3):495-510.
  19. Cotter M, Reisli S, Francisco AA, Wakim KM, Oakes L, Crosse MJ, et al. Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder. Journal of neurodevelopmental disorders. 2023 Apr 1;15(1):11.
  20. Joos K, Gilles A, Van de Heyning P, De Ridder D, Vanneste S. From sensation to percept: the neural signature of auditory event-related potentials. Neuroscience & Biobehavioral Reviews. 2014 May 1;42:148-56.
  21. Polich J. Updating P300: an integrative theory of P3a and P3b. Clinical neurophysiology. 2007 Oct 1;118(10):2128-48.
  22. Didoné DD, Oppitz SJ, Gonçalves MS, Garcia MV. Long-latency auditory evoked potentials: Normalization of protocol applied to normal adults. Arch Otolaryngol Rhinol. 2019;5(03):69-73.
  23. Luck SJ. Event-related potentials.2023.
  24. Raggi A, Serretti A, Ferri R. The P300 component of the auditory event-related potential in adult psychiatric and neurologic disorders: a narrative review of clinical and experimental evidence. International Clinical Psychopharmacology. 2024:10-97.
  25. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of autism and developmental disorders. 1994 Oct;24(5):659-85.
  26. World Medical Association. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. Bulletin of the world health organization. 2003 Jul 2;79(4):373.
  27. Barry RJ, De Blasio FM, Rushby JA, MacDonald B, Fogarty JS, Cave AE. Stimulus intensity effects and sequential processing in the passive auditory ERP. International Journal of Psychophysiology. 2022 Jun 1;176:149-63.
  28. OpenBCI. (n.d.). The complete headset (EEG). Retrieved October 30, 2024, Available from: https://shop.openbci.com/products/the-complete-headset-eeg
  29. SharghiLavan S, Geman O, Toderean R. Speech Perception and Speech Attention: A Case Study Based on Event-Related Potential Using the OpenBCI System. In2024 E-Health and Bioengineering Conference (EHB) 2024 Nov 14 (pp. 1-4). IEEE.
  30. Ptak R, Schnider A. Disorganised memory after right dorsolateral prefrontal damage. Neurocase. 2004 Feb 1;10(1):52-9.
  31. Griffin R, Friedman O, Ween J, Winner E, Happé F, Brownell H. Theory of mind and the right cerebral hemisphere: Refining the scope of impairment. Laterality. 2006 Apr 1;11(03):195-225.
  32. Andreou M, Skrimpa V. Theory of mind deficits and neurophysiological operations in autism spectrum disorders: a review. Brain sciences. 2020 Jun 20;10(6):393.
  33. Ozonoff S, Miller JN. An exploration of right-hemisphere contributions to the pragmatic impairments of autism. Brain and language. 1996 Mar 1;52(3):411-34.
  34. Schuh JM. Pragmatic language abilities: Working memory influences on mutual information. University of Connecticut; 2011.
  35. Razavi F, Pourmohamadreza-Tajrishi M, Haghgoo H, Bakhshi E, Tavakoli S, Miri SM. Relationship between executive functions and pragmatic language in children with autism spectrum disorders. Iranian Rehabilitation Journal. 2019 Sep 10;17(3):225-34.
  36. Haesen B, Boets B, Wagemans J. A review of behavioural and electrophysiological studies on auditory processing and speech perception in autism spectrum disorders. Research in autism spectrum disorders. 2011 Apr 1;5(2):701-14.
  37. Persichetti AS, Shao J, Gotts SJ, Martin A. Maladaptive laterality in cortical networks related to social communication in autism spectrum disorder. Journal of Neuroscience. 2022 Nov 30;42(48):9045-52.
  38. Baron‐Cohen S. The theory of mind deficit in autism: How specific is it?. British Journal of Developmental Psychology. 1991 Jun;9(2):301-14.
  39. Adams MP. Explaining the theory of mind deficit in autism spectrum disorder. Philosophical Studies. 2013 Mar;163(1):233-49.
  40. Jones CR, Simonoff E, Baird G, Pickles A, Marsden AJ, Tregay J, et al. The association between theory of mind, executive function, and the symptoms of autism spectrum disorder. Autism research. 2018 Jan;11(1):95-109.
  41. Friederici AD. The brain basis of language processing: from structure to function. Physiological reviews. 2011 Oct;91(4):1357-92.
  42. Friederici AD, Chomsky N, Berwick RC, Moro A, Bolhuis JJ. Language, mind and brain. Nature human behaviour. 2017 Oct;1(10):713-22.
  43. Turker S, Kuhnke P, Eickhoff SB, Caspers S, Hartwigsen G. Cortical, subcortical, and cerebellar contributions to language processing: A meta-analytic review of 403 neuroimaging experiments. Psychological Bulletin. 2023 Nov;149(11-12):699.
  44. Hugdahl K. 12 dichotic listening in the study of auditory laterality. The asymmetrical brain. 2004;441.
  45. Barrouillet P, Bernardin S, Portrat S, Vergauwe E, Camos V. Time and cognitive load in working memory. Journal of Experimental Psychology: Learning, Memory, and Cognition. 2007 May;33(3):570.
  46. Kononowicz TW, van Rijn H. Decoupling interval timing and climbing neural activity: a dissociation between CNV and N1P2 amplitudes. Journal of Neuroscience. 2014 Feb 19;34(8):2931-9.
آمار
تعداد مشاهده مقاله: 415
تعداد دریافت فایل اصل مقاله: 172