Alavi, Mohaddeseh Sadat, Hosseini, azar, Torabi, Fereshte, Rayati banadkooki, Mitra, Taghadosi, Zahra, Boroushaki, Mohammad Taher. (1404). Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats. , 16(2), 386-397. doi: 10.22038/ajp.2025.26495
Mohaddeseh Sadat Alavi; azar Hosseini; Fereshte Torabi; Mitra Rayati banadkooki; Zahra Taghadosi; Mohammad Taher Boroushaki. "Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats". , 16, 2, 1404, 386-397. doi: 10.22038/ajp.2025.26495
Alavi, Mohaddeseh Sadat, Hosseini, azar, Torabi, Fereshte, Rayati banadkooki, Mitra, Taghadosi, Zahra, Boroushaki, Mohammad Taher. (1404). 'Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats', , 16(2), pp. 386-397. doi: 10.22038/ajp.2025.26495
Alavi, Mohaddeseh Sadat, Hosseini, azar, Torabi, Fereshte, Rayati banadkooki, Mitra, Taghadosi, Zahra, Boroushaki, Mohammad Taher. Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats. , 1404; 16(2): 386-397. doi: 10.22038/ajp.2025.26495

Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats

Avicenna Journal of Phytomedicine
دوره 16، شماره 2، خرداد و تیر 2026، صفحه 386-397    اصل مقاله (2 M)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2025.26495
نویسندگان
Mohaddeseh Sadat Alavi1؛ azar Hosseini1؛ Fereshte Torabi2؛ Mitra Rayati banadkooki3؛ Zahra Taghadosi3؛ Mohammad Taher Boroushaki* 4
1Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Pharmacology
چکیده
Objective: Lead poisoning is one of the oldest occupational and environmental diseases in the world. It can enter the body by being absorbed in water, air, and food. Oxidative stress is one of the mechanisms responsible for lead toxicity. Anti-inflammatory and antioxidant properties are the primary effects of pomegranate seed oil (PSO). This research is designed to determine the impact of PSO on damage to the hippocampus, bone, and bone marrow in rats triggered by lead acetate.
Materials and Methods: Thirty-two adult male rats were subjected to this study. The animals were divided into four groups at random after they had acclimated. The control group received 1 ml/kg of normal saline for 21 days. Animals in the Pb group received 500 ppm of lead acetate in drinking water for 21 days. Pb+ PSO 0.4 ml/kg and Pb+ PSO 0.8 ml/kg received 0.4 or 0.8 ml/kg of PSO intraperitoneally, concomitant with exposure to lead acetate for 21 days. Blood, bone, bone marrow, and hippocampus samples were taken after the treatment for measuring malondialdehyde (MDA), thiol content and superoxide dismutase (SOD).  
Results: Our results revealed that 0.8 ml/kg of PSO significantly decreased malondialdehyde in bone marrow, serum, and hippocampus. It also could increase thiol in serum and superoxide dismutase in bone marrow.
Conclusion: PSO could protect against lead-induced damage in bone, bone marrow, and hippocampus of treated animals through reduction of oxidative stress. 
کلیدواژه‌ها
Pomegranate seed oil؛ Lead acetate؛ Oxidative stress؛ Hippocampus؛ Bone marrow
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