Effect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 7، دوره 3، شماره 3، شهریور 2013، صفحه 248-253 اصل مقاله (209.34 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2013.264 | ||
| نویسندگان | ||
| Karim Dolati1؛ Hassan Rakhshandeh1؛ Mohammad Naser Shafei* 2 | ||
| 1Pharmacological Research Center of Medicinal Plants and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran | ||
| 2Neuroscience Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran | ||
| چکیده | ||
| Objective: The use of drugs with herbal origin is increasing for treatment of gastrointestinal (GI) disorders. Rosa damascena (R. damascena) is a well-known plant suggested to have beneficial effect on GI system. In this study, the effect of aqueous fraction of R. damascena on the contractionsofisolated guinea pig ileum was investigated. Materials and Methods: Aqueous fraction of plant was obtained from ethanolic extract after ethyl acetate and n-butanol fractions were discarded. To evaluate effect of this fraction on ileum contraction, guinea pig ileum was removed and mounted on organ bath and its contraction was recorded. Effect of various concentrations (0.66, 0.83, and 1.3 mg/ml) of aqueous fraction on ileum contraction in comparison with Ach in presence and absense of atropine, a muscarinic antagonist of cholinergic, was evaluated. The response of ileum to 1 µg/ml of acetylcholine was considered as 100% response. Results:Our results showed that aqueous fractions of R. damascena dose-dependently increased basal guinea pigs ileum contractions (pConclusion: It is concluded that aqueous fraction of R. damascena has mild excitatory effect on ileum contraction and this fraction may be beneficial as a mild laxative agent. | ||
| کلیدواژهها | ||
| Aqueous Fractions؛ Cholinergic system؛ Guinea pig؛ Ileum؛ Rosa damascena | ||
| مراجع | ||
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