سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Sanjani, Fadillah, Haryuna, Tengku-Siti-, Farhat, Farhat, Nasution, Syafrizal, Harahap, Juliandi, Lubis, Yuliani, Asroel, Harry, Khalid, Khalisanni. (1404). Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients. , 37(4), 197-204. doi: 10.22038/ijorl.2025.77733.3633
Fadillah Akbar Sanjani; Tengku-Siti- Hajar Haryuna; Farhat Farhat; Syafrizal Nasution; Juliandi Harahap; Yuliani M Lubis; Harry Agustaf Asroel; Khalisanni Khalid. "Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients". , 37, 4, 1404, 197-204. doi: 10.22038/ijorl.2025.77733.3633
Sanjani, Fadillah, Haryuna, Tengku-Siti-, Farhat, Farhat, Nasution, Syafrizal, Harahap, Juliandi, Lubis, Yuliani, Asroel, Harry, Khalid, Khalisanni. (1404). 'Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients', , 37(4), pp. 197-204. doi: 10.22038/ijorl.2025.77733.3633
Sanjani, Fadillah, Haryuna, Tengku-Siti-, Farhat, Farhat, Nasution, Syafrizal, Harahap, Juliandi, Lubis, Yuliani, Asroel, Harry, Khalid, Khalisanni. Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients. , 1404; 37(4): 197-204. doi: 10.22038/ijorl.2025.77733.3633

Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients

Iranian Journal of Otorhinolaryngology
دوره 37، شماره 4، مهر و آبان 2025، صفحه 197-204    اصل مقاله (250.13 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2025.77733.3633
نویسندگان
Fadillah Akbar Sanjani1؛ Tengku-Siti- Hajar Haryuna* 1؛ Farhat Farhat1؛ Syafrizal Nasution2؛ Juliandi Harahap3؛ Yuliani M Lubis1؛ Harry Agustaf Asroel1؛ Khalisanni Khalid4
1Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur No. 5, Medan, 20155, Indonesia.
2Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansur No. 5, Medan 20155, Indonesia.
3Department of Community Medicine, Faculty of Medicine, Universitas Sumatera, Utara, Jl. Dr. Mansur No. 5, Medan, 20155, Indonesia.
4Malaysian Agricultural Research and Development Institute (MARDI), MARDI Headquarters, Persiaran MARDI-UPM, 43400 Serdang, Selangor, Malaysia.
چکیده
Introduction:
Chronic Kidney Disease (CKD) is considered a public health issue because its frequency is increasing in adults. When a person experiences renal failure, one of the most researched solutes that builds up in plasma is indoxyl sulfate. This toxin can attach to proteins, and it is a byproduct of the tryptophan metabolism in the diet, which provides pro-oxidative and pro-inflammatory activity. In CKD, the redox imbalance associated with oxidative stress is associated with pathophysiological issues brought on by the buildup of uremic toxins. The cochlea is highly susceptible to oxidative stress, which consequently causes permanent cochlear degeneration. To better understand the connection between Indoxyl sulfate levels and hearing loss in CKD patients, we examined the results of pure tone audiometry and OAE examinations.
 
Materials and Methods: This research was conducted on 27 people with stage 5 CKD who had their blood plasma levels of indoxyl sulfate measured before having their hearing ability assessed by OAE and pure tone audiometry. Next, a correlation test was carried out between the results of Indoxyl sulfate levels and the results of hearing function tests in CKD patients. 
Results: The indoxyl sulfate value and degree of auditory impairment had a strong positive correlation, according to the Spearman correlation test. (r = 0.881; p = 0.001) and an inverse relationship between the Indoxyl sulfate value and SNR (r = -0.761; p = 0.001).  
Conclusion:CKD patients have impaired hearing, which is correlated with the amount of uremic toxin Indoxyl Sulfate that has accumulated.
کلیدواژه‌ها
Chronic kidney disease؛ Indoxyl sulfate؛ Hearing loss؛ Pure tone audiometry؛ OAE
مراجع
  1. Seo YJ, Ko SB, Ha TH, Gong TH, Bong JP, Park DJ, et al. Association of hearing impairment with chronic kidney disease: a cross-sectional study of the Korean general population. BMC Nephrology. 2015 Sep 16;16(1):154.
  2. Ulfa L, Muyassaroh M, Naftali Z, Arwanto A, Murbani I. The Effect of Hemodialysis on the Incidence of Sensorineural Hearing Loss in Chronic Kidney Failure Patients. Bandung Medical Magazine. 2016 Jun 29;48(2):98–104.
  3. Muyassaroh M, Ulfa L. Sensorineural hearing loss in chronic renal failure undergoing hemodialysis. Oto Rhino Laryngologica Indonesiana (ORLI). 2013;43(2):163–70.
  4. Stavroulaki P, Nikolopoulos TP, Psarommatis I, Apostolopoulos N. Hearing evaluation with distortion-product otoacoustic emissions in young patients undergoing haemodialysis. Clinical Otolaryngology & Allied Sciences. 2001; 26(3): 235–42.
  5. Leong SC, Sirich TL. Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins. 2016 Dec;8(12):358.
  6. Lu CL, Zheng CM, Lu KC, Liao MT, Wu KL, Ma MC. Indoxyl-Sulfate-Induced Redox Imbalance in Chronic Kidney Disease. Antioxidants. 2021 Jun; 10(6):936.
  7. Gonzalez-Gonzalez S. The role of mitochondrial oxidative stress in hearing loss. Neurol Disord Therap [Internet]. 2017 [cited 2023 Jul 23];1(3). Available from: http://www.oatext.com/the-role-of-mitochondrial-oxidative-stress-in-hearing-loss.php
  8. The 11th Report of Indonesian Renal Registry [Internet]. 2018. Available from: https:// www. indonesianrenalregistry. org/data/ IRR%202018.pdf
  9. Aisara S, Azmi S, Yanni M. Clinical Description of Chronic Kidney Disease Patients Undergoing Hemodialysis at Dr. M. Djamil Padang General Hospital. Andalas Health Journal. 2018 Mar 10;7(1):42–50.
  10. Chang PY, Chien LN, Lin YF, Wu MS, Chiu WT, Chiou HY. Risk factors of gender for renal progression in patients with early chronic kidney disease. Medicine (United States) [Internet]. 2016 Jul 1 [cited 2023 Jul 23];95(30). Available from: http:// www. scopus.com/ inward/record.url? scp= 84982856700 &partner ID=8YFLogxK
  11. Pushpa K.C., Jayaprabha S, Mohan C, Gracious N, Jaya C.C., Satheesh S. Sensorineural hearing loss in chronic renal failure patients in a tertiary care centre. International Journal of Health and Clinical Research. 2021 May 11;4(9):261–7.
  12. Purnami N, Roosmilasari A, Artono A, Mardiana N. Correlation between blood urea nitrogen level and cochlear outer hair cell function in non-dialysis chronic kidney disease patients. Journal of Public Health Research [Internet]. 2022 Mar 3 [cited 2023 Jul 23];11(2). Available from: http:// www. scopus .com/inward/ record.url? scp=85129626908&partnerID=8YFLogxK
  13. Govender SM, Govender CD, Matthews G. Cochlear function in patients with chronic kidney disease. South African Journal of Communication Disorders. 2013 Nov 27;60(1):44–9.
  14. Dey D, Shilpa C, Sandeep S, Shetty MS. Early Detection of Dwindling Cochlear Sensitivity in Patients with Chronic Kidney Disease. An International Journal of Otorhinolaryngology Clinics. 2022;14(1):17–21.
  15. Reddy EK, Surya Prakash DR, Rama Krishna MGKD. Proportion of hearing loss in chronic renal failure: Our experience. Indian Journal of Otology. 2016 Mar;22(1):4.
  16. Somashekara KG, Gowda BVC, Smitha. S.G., Mathew AS. Etiological evaluation of hearing loss in chronic renal failure. Indian Journal of Basic & Applied Medical Research. 2015;4(2):194–9.
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  1. Pebriarti IW. Relationship between serum indoxyl sulfate levels and duration of hemodialysis in chronic kidney disease patients at Dr. Soebandi Hospital. [Internet] [thesis]. Airlangga University; 2018 [cited 2023 Jul 23]. Available from: http://lib.unair.ac.id
  2. Lekawanvijit S, Kompa AR, Wang BH, Kelly DJ, Krum H. Cardiorenal Syndrome. Circulation Research. 2012 Nov 9;111(11):1470–83.
  3. Poirrier AL, Pincemail J, Ackerveken PVD, Lefebvre PP, Malgrange B. Oxidative Stress in the Cochlea: An Update. Current Medicinal Chemistry. 17(30):3591–604.
آمار
تعداد مشاهده مقاله: 64
تعداد دریافت فایل اصل مقاله: 47