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Rezaeetalab, Fariba, Zeraati, Abbas Ali, Mostafania, Sayyed Hosien, Basiri, Bahareh, M Lari, Shahrzad. (1393). Renal Fractional Excretion of Sodium in Relation to Arterial Blood Gas and Spirometric Parameters in Chronic Obstructive Pulmonary Disease. , 2(2), 147-151. doi: 10.22038/jctm.2014.2609
Fariba Rezaeetalab; Abbas Ali Zeraati; Sayyed Hosien Mostafania; Bahareh Basiri; Shahrzad M Lari. "Renal Fractional Excretion of Sodium in Relation to Arterial Blood Gas and Spirometric Parameters in Chronic Obstructive Pulmonary Disease". , 2, 2, 1393, 147-151. doi: 10.22038/jctm.2014.2609
Rezaeetalab, Fariba, Zeraati, Abbas Ali, Mostafania, Sayyed Hosien, Basiri, Bahareh, M Lari, Shahrzad. (1393). 'Renal Fractional Excretion of Sodium in Relation to Arterial Blood Gas and Spirometric Parameters in Chronic Obstructive Pulmonary Disease', , 2(2), pp. 147-151. doi: 10.22038/jctm.2014.2609
Rezaeetalab, Fariba, Zeraati, Abbas Ali, Mostafania, Sayyed Hosien, Basiri, Bahareh, M Lari, Shahrzad. Renal Fractional Excretion of Sodium in Relation to Arterial Blood Gas and Spirometric Parameters in Chronic Obstructive Pulmonary Disease. , 1393; 2(2): 147-151. doi: 10.22038/jctm.2014.2609

Renal Fractional Excretion of Sodium in Relation to Arterial Blood Gas and Spirometric Parameters in Chronic Obstructive Pulmonary Disease

Journal of Cardio-Thoracic Medicine
مقاله 3، دوره 2، شماره 2، مرداد 2014، صفحه 147-151    اصل مقاله (366.79 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/jctm.2014.2609
نویسندگان
Fariba Rezaeetalab1؛ Abbas Ali Zeraati2؛ Sayyed Hosien Mostafania* 3؛ Bahareh Basiri3؛ Shahrzad M Lari4
1Pulmonologist, Chronic Obstructive Pulmonary Disease Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Nephrologist, Department of Nephrology , Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Resident of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Pulmonologist, Cardio‐Thoracic Surgery & Transplant Research Center, Emam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: Arterial gas derangement could change urinary sodium excretion in Chronic Obstructive Pulmonary Disease (COPD) patients.There are very few and conflicting data in regards to the measurement of fractional excretion of sodium in COPD patients. The main aim of this study was to assess the relationship between renal fractional excretion of sodium(FeNa) with arterial blood gas and spirometric parameters in COPD.
Materials and Methods: This study was a cross-sectional study performed on 40 consecutive stable COPD outpatients in 2 main general hospitals (Emam Reza, Ghaem) in Mashhad/Iran between 2011 and 2012. We investigated the relationship of renal FeNa with arterial blood gas parameters including HCO3, PH, PaCO2 and PaO2, and spirometric parameters. Analysis was done by SPSS v16 with a statistically meaningful
p value of less than 0.05.
Results: Mean age was 65.97±10.77 SD years and female to male ratio was 0.26. A renal FeNa of less than 1% was presented in 27% patients. There was a significant, positive relationship between renal FeNa and
PaO2 (P=0.005, r=0.456). The correlations between PaCO2, HCO3, PH and spirometric parameters were not seen (P>0.05), but there was a significant relationship between Urine Na and PaO2. Outstanding, it seems likely that kidneys of COPD patients are responsible for sodium retaining state particularly in the presence of hypoxemia.
Conclusion: This study indicates that in COPD patients, PaO2 but not PaCO2 is related to renal FeNa which shows the probable role of hypoxemia on sodium output in COPD patients. However, some caution is needed for interpretation of the probable role of hypercapnia on sodium retention in COPD.
کلیدواژه‌ها
Arterial Blood Gas؛ Chronic Obstructive Pulmonary Disease؛ Fractional Excretion؛ Hypoxemia؛ sodium
آمار
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